New Zealand activist Posie Parker attacked with tomato soup, water and placards for saying that only real females are women

Image: New Zealand activist Posie Parker attacked with tomato soup, water and placards for saying that only real females are women

(Natural News) The cult of transgender delusion nearly murdered a woman this week for stating publicly that a biological male is not, and can never be, a “woman.”

Women’s rights activist Posie Parker appeared in New Zealand’s Albert Park to deliver a speech about what it means to be a woman. Citing biology and science, Parker clarified, in essence that cutting off one’s genitals and putting on a wig and an ugly dress does not a woman make.

For telling the truth, Parker was attacked by an angry mob, which threw placards, water, and tomato soup all over her. Parker had to be escorted off the stage and out of the vicinity for her own safety after “huge men screamed insults and expletives in her face.”

“I genuinely thought that if I fell to the floor, I would never get up again,” Parker revealed about the horrific incident. “My children would lose their mother and my husband would lose his wife.”

Watch the video footage below, which was captured the moment that Parker had to be escorted away from the rally for her own safety:

#WATCH RNZ’s Jordan Dunn captured the moment that Posie Parker was escorted away from the rally.

The counter-protest crowd gathered in Albert Park this morning before Parker’s speech, and made a cacophany of noise to drown her speech out.


— RNZ (@radionz) March 25, 2023

(Related: A few years back, a trans activist called “Alok Vaid-Menon” stated that it thinks “little girls are kinky.”)

No, a biological male can never be a “woman”

Parker’s “crime” was to state in public that “a woman is an adult human female” – and nothing else. No amount of play-pretend or delusional mental illness can ever change that fact, despite what the most vocal and violent trans extremists claim.

“Next time you’re reading a history book and find yourself wondering how Salem came to be consumed by such swirling hysteria, watch the clips of Posie’s persecution in New Zealand. This is how it happens,” wrote Brendan O’Neill for The Spectator about the disturbing incident.


“This is how the fear of witches can overrule reason and unleash the darkest, most punitive passions of the mob.”

Parker, whose real name is Kellie-Jay Keen-Minshull, is a well-known figurehead who defends real women and the biology that defines them. She does not accept the trans delusions that are sweeping the West, and because of this she is hated by the trans cult.

Parker regularly organizes public events called “Let Women Speak” across not only New Zealand but also Australia, the United Kingdom, and even parts of the United States. For the past several weeks, her focus has been on Australia and New Zealand.

“She thinks a man never becomes a woman, no matter how many hormones he takes or surgeries he undergoes,” O’Neill explained about what Parker believes. “She thinks if you were born male, you will die male, and in the time in between you have no right whatsoever to enter any women-only space.”

“This is heresy. Dissenting from the gospel of gender ideology is to the 21st century what dissenting from the actual gospels was to the 15th. And so Parker must be punished. It was a modern-day stoning, so mercifully they only threw soup and water and planks of cardboard at the blasphemer.”

While most of the U.S. is thankfully of the same mindset as Parker, things are moving in the wrong direction, especially when those opposed to the truth are becoming public school teachers who make it their mission to indoctrinate the next generation into rejecting biology, science, and truth.

The latest news about the trans cult’s violent tendencies can be found at

Sources for this article include:

Inflation remains a problem for middle- and lower-income Americans as Biden's Federal Reserve keeps raising interest rates

Image: Inflation remains a problem for middle- and lower-income Americans as Biden’s Federal Reserve keeps raising interest rates

(Natural News) Inflation continues to haunt middle and lower-income working folks in the United States as the administration of President Joe Biden is still unable to properly resolve the inflation crisis.

In an interview with Fox Business, conservative economist and commentator Larry Kudlow talked about it and blamed Biden’s policies for the ongoing situation. (Related: Federal government hides true rate of inflation by changing how CPI is calculated.)

“Big time pessimism is out there and Joe Biden owns it because inflation is the cruelest tax of all. It continues to haunt middle and lower-income working folks. It has driven up interest rates on credit cards, home mortgages, car loans, et cetera. Inflation is rising faster than wages and government spending and bank bailouts have gotten under the skin of Americans,” said Kudlow.

“I don’t really want to say America is in decline, but I do fret and I will say for the umpteenth time: We need leadership that will be a guardian for economic growth and prosperity and then good old-fashioned values will soon return to a more confident America.”

Inflation still running at a high pace, Americans very concerned

A survey by the Conference Board, a non-profit business research organization, noted that Americans are optimistic that the American economy will get better in the near future.

But despite the slightly higher consumer confidence, inflation expectations remain very high. Americans expect prices to rise by at least 6.3 percent in the next 12 months, similar to how survey participants felt about the economy in February.


Ataman Ozyildirim, senior director of economics at the Conference Board, explained that consumers are more likely to feel confident about their future economic prospects while remaining “slightly less optimistic about the current landscape.”

This is supported by a Wall Street Journal-National Opinion Research Center poll, which found that nearly two-thirds of Americans believe inflation is a major concern.

“No matter how much they increase your pay, everything else is going up,” said Kristy Morrow, a coordinator for a hospital in Big Springs, Texas, in an interview with the Wall Street Journal.

To make matters worse, the Federal Reserve just increased interest rates by 25 basis points (0.25 percent) this March, the ninth interest rate hike since last year. This increase takes the benchmark federal funds rate to a target range of between 4.75 percent and five percent. This rate sets what banks charge each other for overnight lending and feeds into the rates of consumer debt like auto loans, credit card debt and mortgages.

“The process of getting inflation back down to two percent has a long way to go and is likely to be bumpy,” said Fed Chair Jerome Powell. He also rejected the idea of cutting interest rates to pre-inflation crisis levels for the remainder of 2023.

“We are committed to restoring price stability and all of the evidence says that the public has confidence that we will do so, that will bring inflation down to two percent over time,” Powell added. “It is important that we sustain that confidence with our actions, as well as our words.”

“[Inflation] would have to be a lot softer to take the hike out. By stopping here, it exposes them to risk of inflation expectations accelerating,” claimed Tom Simons, money market economist for investment banking group Jefferies. “If they do that, they are risking having to make bigger moves later when they don’t know what the environment will look like. It makes sense to stay the course and keep everything in check. They do have more work to do.”

Learn more about the Biden administration’s policies at

Watch this clip from the “War Room” on Real America’s Voice as host Steve Bannon talks to Peter Navarro, former special assistant to former President Donald Trump, about how the inflation crisis is solely a product of Joe Biden.

This video is from the News Clips channel on

More related stories:

Alarming new numbers show why countless Americans will starve to death in the year ahead with one retailer who ‘can’t afford’ to sell eggs anymore.

Federal Reserve will keep increasing interest rates despite worsening banking crisis.

Federal Reserve to print another $2 trillion in fake fiat funny money to bail out financial terrorists, further devaluing dollar.

The endgame of the banking crisis is hyperinflation and currency collapse: WATCH as Andy Schectman explains.

Hyperinflation meets the Great Depression – Andy Schectman warns Mike Adams about the catastrophic banking collapse now accelerating.

Sources include: 1 2

Disney to begin mass layoff of 7,000 employees this week

Image: Disney to begin mass layoff of 7,000 employees this week

(Natural News) The Walt Disney Company announced on Monday, March 27, that it already began letting go of 7,000 of its workers in a mass layoff the company announced earlier this year. Chief Executive Officer Bob Iger said the layoffs are necessary for the company to control costs and create a more “streamlined” business.

The job cuts were initially announced in February and will affect most divisions within the company, including Disney’s media and distribution division (Disney Entertainment), parks and resorts (Disney Parks, Experiences and Products) and the sports television channel ESPN. This is part of Disney’s plan to cut around $5.5 billion in costs, including around $3 billion from what it currently spends on content. (Related: Disney is on the verge of financial collapse, leaked memo reveals.)

“This week, we began notifying employees whose positions are impacted by the company’s workforce reductions,” wrote Iger in a memo sent to employees and seen by media outlets. “Leaders will be communicating the news directly to the first group of impacted employees over the next four days.

“A second, larger round of notifications will happen in April with several thousand more staff reductions,” he added. “And we expect to commence the final round of notifications before the beginning of summer to reach our 7,000-job target.”

Disney did not reveal the full extent of the first round of layoffs on Monday or the exact impact it will have on day-to-day operations at the company. But sources who spoke with media outlets noted that Disney’s television operations appear to be taking the hardest hits.


Among the notable staffers let go are Jayne Bieber, senior vice president for production at the television channel Freeform and the content brand Onyx Collective; Mark Levenstein, head of production and post-production at the streaming service Hulu; and Elizabeth Newman, head of the acquisitions department at Disney.

“For our employees who aren’t impacted, I want to acknowledge that there will no doubt be challenges ahead as we continue building the structures and functions that will enable us to be successful moving forward,” wrote Iger. “I ask for your continued understanding and collaboration during this time.”

“This company is home to the most talented and dedicated employees in the world,” wrote Iger. “It makes it all the more difficult to say goodbye to wonderful people we care about. I want to offer my sincere thanks and appreciation to every departing employee for your numerous contributions and your devotion to this beloved company.”

Disney retrenchment part of downsizing in entertainment, media industries

Media and entertainment industries in the United States have been undergoing a series of retrenchments as companies like Disney and Netflix are beginning to prioritize focusing on profitability over growth. Warner Bros., Discovery and many other legacy media companies have also announced cuts to jobs and spending.

Disney noted that its streaming business, led by Disney+, Hulu and ESPN+, is still not profitable. The company added that its streaming services will only stop losing money in 2024 after losses narrowed to $1.1 billion from $1.5 billion in its latest quarter. Iger even noted that he would consider selling Hulu if it continues to be unprofitable.

Since taking over as CEO in late November 2022, Iger has started restructuring the organization of the Walt Disney Company into three core business segments: entertainment ESPN and parks, resorts and products.

In the company’s first-quarter earnings report on Feb. 8, Iger said the reorganization “will result in a more cost-effective, coordinated and streamlined approach to our operations, and we are committed to running our business more efficiently, especially in a challenging economic environment.”

Learn more about the state of the American economy at

Watch this clip from OAN discussing how Disney continues to push left-wing, woke propaganda in children’s content.

This video is from the News Clips channel on

More related stories:

Many companies are already on their second round of mass layoffs.

Jobless claims soar to five-month high as recession signals blare.

The job cuts that are coming are going to be super brutal.

A job-destroying economic vortex has just been unleashed: Large-scale layoffs will accelerate through 2023, impoverishing millions.

WOKE is BROKE: Disney suffers devastating operating losses and begins mass layoffs after pushing trans-everything themes as hard as possible.

Sources include:

Dave Blaze calls for end to the STUDENT LOAN racket

Image: Dave Blaze calls for end to the STUDENT LOAN racket

(Natural News) George Online CEO Dave Blaze called for an end to the college and university student loan racket.

“I think that the whole racket needs to come to an end. The racket is that these colleges and universities that are churning out nothing more than unwitting socialists and communists need to stop obtaining funds through a student,” he told Gene Ho of “About George” during the show’s March 23 episode.

The co-founder of The Blaze Team and Blaze Web Services noted that students going to medical school were spending $60,000 to $90,000 per semester for four years, followed by post-graduate work and residency at a hospital. These students are saddled with education debt and must pay their debt when they get a job offer from a hospital.

“The hospital gives you a contract where you’re going to work at the hospital as a resident doctor, emergency room, whatever it is, and they will pay you a certain salary and so forth. So now you have enough money to pay back, start making payments on your debt to the university. But now also the hospital gets to fully dictate to you their policies,” Blaze explained.

“And you as a physician must follow the hospital’s policies as opposed to maybe making suggestions and prescriptions for the patients that you feel are in the best for that particular patient. You’re not allowed to do that you have to follow the hospital policy or you’re out on your behind. And now you have all that debt to continue to deal with.”

Blaze pointed out that this is the horrible racket the student loans are actually bringing forward. He claimed these colleges and universities are wiping out that debt and starting from scratch. The George Online CEO added that they are getting the money through endowments from former student corporations or government funding and government loans to colleges and universities.


Blaze: People paying their student loans forced into BANKRUPTCY

According to Blaze, the whole college-university student loan thing is a giant money-making racket, and if they want to stay in business they should beg money from corporations, former students, endowments or other ways they could get their funds. He also said these colleges and universities are getting the money because the government funds it.

The Blaze Team and Blaze Web Services co-founder said these people who are paying their student loans are also being forced into bankruptcy.

Meanwhile, program co-host Rachel Writeside Blonde commented she totally disagrees with student loans being forgiven. She pointed out that a college or a high school graduate has a choice between going into the trades, getting a real estate license or going to college. (Related: Shocking number of college students think their student loans will be forgiven.)

The executive managing editor of George Online said they would have to take a training. If they fail at it, no one will come and bail them out because it is a choice that they had made.

According to her, it is a risk that students take to go to college and to pay that money. She noted that American parents are now waking up to the fact that college is not the only option. They are starting to see that the student loan is a kind of scam to get young people to go and spend tens of thousands of dollars they will pay off until they turn 40.

“It’s crazy that people are wanting to get that forgiven,” Writeside Blonde said.

Follow for more news about American colleges and universities.

Watch the March 23 episode of “About George” that discusses student loans below.

This video is from the AMPNews channel on

More related stories:

Navy offering up to $65,000 to pay off student loans of recruits as enlistment figures continue to decline.

Katie Petrick and David Fiorazo discuss study that says majority of students find college too difficult.

Biden’s plan to write off student loans using post-9/11 national emergency law is a form of political posturing

Massive student loan fraud scam: 99.8% of repayment data fraudulently altered by schools.

HIGHER EDUCATION ROBBERY: American taxpayers will be forced to pay an average of $2500 each if student loans are canceled.

Sources include:

Is This One of the Best Nutrients for Your Eyes and Brain?

  • Of all the known carotenoids, only lutein and zeaxanthin cross the blood-retina barrier to form macular pigment

  • Lutein is also found in the brain, hinting at its importance for cognitive function

  • Lutein, found in green leafy vegetables, egg yolks and more, helps form the retinal macular pigment, which is responsible for optimizing your visual performance and serves as a biomarker for the risk of macular diseases

  • Lutein is protective against age-related macular degeneration, cataracts, glaucoma and other eye diseases

  • Among young and older adults, lutein and zeaxanthin supplementation improves cognitive function

Visit Mercola Market


While there are about 850 known carotenoids, most are not found in the human body

and only lutein, zeaxanthin and astaxanthin cross the blood-retina barrier to form macular pigment.

Your retina is an extension of your brain,

where lutein also accumulates throughout the human lifespan, hinting at its importance for both vision and cognitive function.

In fact, if you have dementia, you’re likely deficient in lutein, which crosses the blood-brain barrier and has a protective, anti-inflammatory effect.

While lutein is available in supplement form, it’s also found in a wide variety of foods, including dark leafy greens, avocados and egg yolks.

Lutein concentrates in your macula,

which is the part of your retina responsible for central vision. Along with zeaxanthin and mesa-zeaxanthin (a metabolite of lutein), these three carotenoids form the retinal macular pigment, which not only is responsible for optimizing your visual performance but also serves as a biomarker for the risk of macular diseases.

Lutein is also found in the lens, where it helps protect against cataracts and other age-related eye diseases.

Among carotenoids, lutein is the most efficient at filtering out blue light — the type that comes from cellphones, computers, tablets and LED lights.

Blue light induces oxidative stress in your eyes, which increases the risk of cataracts and macular diseases. Lutein, however, acts as a shield against it. According to a team of researchers from Harvard Medical School and The University of Hong Kong, writing in the journal Nutrients:

“As the peak wavelength of lutein’s absorption is around 460 nm which lies within the range of blue light, lutein can effectively reduce light-induced damage by absorbing 40% to 90% of incident blue light depending on its concentration.

The outer plexiform layer of the fovea, where the majority of axons of rod and cone photoreceptor cells are located, is the retinal layer having the highest density of macular carotenoids including lutein. Hence the photoreceptors are protected against photo-oxidative damages from blue light.”

Lutein also suppresses inflammation and the expression of vascular endothelial growth factor (VEGF),

which stimulates the formation of blood vessels and is upregulated in many tumors.

“As inflammation and abnormal angiogenesis in retinal vasculature are major pathogenic mechanisms of many ocular diseases, lutein’s functions in suppressing inflammatory response and VEGF expression make it effective in reducing the severity of these diseases,” the team noted.

Further, lutein may improve visual acuity while helping to reduce cell loss after injury.

It is important to understand that VEGF can be very helpful or detrimental depending on the circumstances. When building muscle, VEGF expression is vital to nourishing Type 2 muscle fiber stem cells. However, if there is a disease process going on, then excessive VEGF levels can be pathologic. In healthy people, though, VEGF expression is generally considered healthy.

In my view the most important strategy to prevent age-related macular degeneration (AMD) is through the radically lowering of the omega-6 fat linoleic acid. AMD was virtually unknown prior to the refining of seed oils in the late 1800s. Now it is a leading cause of blindness.

Lutein also may help prevent AMD,

which is the leading cause of vision loss and blindness for Americans aged 65 and older.

By 2050, it’s estimated that 288 million people worldwide will be affected, up from 196 million in 2020.

Not only are higher blood levels of lutein and other carotenoids associated with a lower risk of AMD, but one study found people with the highest lutein and zeaxanthin intake had a 65% lower incidence of neovascular AMD compared to those who consumed the least.

Lutein also shows promise for diabetic retinopathy, which affects one-third of diabetes patients.

Along with improving retinal thickness and function, lutein may lower the risk of development or progression of diabetic retinopathy.

Cataracts, which are estimated to affect over 90% of adults aged 70 and over, are also less common in people with higher lutein intakes.

In one study, those who consumed the most lutein had a 50% lower likelihood of cataracts than those who consumed the least.

Glaucoma, another leading cause of blindness worldwide, is also linked to lutein consumption. A systematic review revealed that lutein enhanced neuroprotection of retinal ganglion cells, helping to preserve synaptic activity.

Further, not only was greater consumption of carotenoids in the diet associated with a lower glaucoma risk, but higher carotenoid levels in macular pigment helped improve visual performance in eyes affected by the disease.

Even myopia, or nearsightedness, which causes faraway objects to appear blurry while close-up objects look clear, may have a lutein connection.

In a study looking into the effects of vitamin D and ultraviolet B exposure on myopia, it was found, unexpectedly, that subjects with the highest lutein concentrations had 40% reduced odds of myopia.

While lutein is well-known for its role in eye health, its role in brain health is being increasingly explored. The connection makes sense, since as your vision worsens with age, so too may your cognitive abilities.

Research shows visual impairment at a distance is associated with declining cognitive function over time, while “maintaining good vision may be an important interventional strategy for mitigating age-related cognitive declines.”

Meanwhile, studies support the beneficial effects of lutein on brain health. In a trial of young, healthy adults, supplementation with lutein and zeaxanthin improved levels of these carotenoids in the central nervous system along with boosting cognitive function.

Among older adults with a mean age of 73.7 years, lutein and zeaxanthin supplementation also improved cognitive function, including boosts in complex attention and cognitive flexibility domains, compared to those taking a placebo.

Men taking part in the study also had improvements in composite memory. These benefits were seen with a daily lutein and zeaxanthin dose equivalent to that found in one-half cup of cooked kale or 1 cup of cooked spinach.

A literature search involving eight clinical trials further revealed that lutein and zeaxanthin in the blood or macula are associated with cognitive performance, and “there is an inverse relationship between a higher amount of macular pigment in the blood and lower risk of mild cognitive impairments or Alzheimer’s disease.”

In another example, among 60 adults between the ages of 25 and 45, those with higher levels of lutein in middle-age had more youthful neural responses than those with lower levels.

The researchers suggested eating more lutein-rich foods could therefore benefit your brain in middle age:

“While some age-related cognitive decline is to be expected in healthy aging, our data suggest that these effects may be less pronounced among adults with greater retinal carotenoid status, a marker of dietary patterns characterized by greater intake of green and leafy vegetables. Furthermore, these practices may provide neuro-cognitive benefit before the onset of older age, in early to middle adulthood.”

Lutein’s ability to protect against oxidative stress may also boost cardiometabolic health, according to a systematic review and meta-analysis. Both higher dietary intake and higher blood concentrations of the carotenoid were associated with better cardiometabolic health, including a lower risk of metabolic syndrome, coronary heart disease and stroke.

Lutein may support optimal cardiometabolic health by inducing beneficial vascular changes and offering antioxidant and immunomodulatory effects. Lutein’s anti-inflammatory effects also appear to by systemic, not restricted to the eyes, including an association with lower c-reactive protein (CRP),

a measure of heart disease risk.

Top Ten Sources of Lutein

Your body cannot make lutein, so you must get it from your diet. Following are 10 foods that are particularly rich sources of lutein.

  • Dark leafy greens

  • Carrots

  • Broccoli

  • Egg yolks

  • Red and yellow peppers

  • Sweet corn

  • Avocados

  • Raspberries

  • Cherries

  • Paprika

Lutein and other carotenoids are fat-soluble, so to optimize absorption be sure to consume it along with a source of healthy fat, such as coconut oil or grass-fed butter. Because organic, pastured egg yolks contain fat, they’re among the healthiest sources of lutein. You can often tell the eggs are free-range by the color of the egg yolk. Foraged hens produce eggs with bright orange yolks, indicative of higher amounts of lutein and zeaxanthin.

Further, consuming eggs along with vegetables that contain lutein may increase its absorption. In fact, eating whole eggs along with a raw mixed-vegetable salad increased absorption of lutein and zeaxanthin by four- to five-fold.

While there’s no recommended daily intake for lutein, one study found, “Dietary concentrations between 6 and 20 mg per day of lutein have been associated with a reduced risk of ocular disorders such as cataracts and age-related macular degeneration.”

Another paper, published in 2019 in PLOS ONE, found benefits to vision in those who took 10 mg or 20 mg of lutein per day, explaining:

“Our stratified analyses suggest the importance of providing lutein at sufficiently high doses and durations: daily doses of at least 20mg showed efficacy within 6 months, compared to 1 year for daily doses of 10mg. However, at least one study showed that 10 mg lutein had the same effect as 20 mg per day, which contradicts our results.

This raises the possibility that the efficacy of lutein supplementation depends on multiple factors. In any event, lutein or zeaxanthin appears to be safe in rats at up to 400mg/kg per day, and lutein appears to be safe in humans at up to 20mg per day.”

While the optimal dose of lutein in supplement form is still being determined, increasing your intake of lutein-rich foods is a simple and effective way to boost your levels of this important nutrient.

>”,”action”:null,”class”:null}”>NEXT ARTICLE >>

Disclaimer: The entire contents of this website are based upon the opinions of Dr. Mercola, unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked.

The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Mercola and his community. Dr. Mercola encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. The subscription fee being requested is for access to the articles and information posted on this site, and is not being paid for any individual medical advice.

If you are pregnant, nursing, taking medication, or have a medical condition, consult your health care professional before using products based on this content.

Can Melatonin Impact Your Eye Health?

melatonin and eye health

  • Patients with glaucoma who took melatonin supplements had decreased intraocular pressure

  • Melatonin also helps to restore disrupted circadian rhythms in people with glaucoma

  • Melatonin counteracts oxidative damage in the lens and may be a “potential therapeutic agent for cataract prevention/management”

  • Melatonin may also be useful for neurovascular age-related macular degeneration (AMD) and dry AMD

  • Melatonin also has antiviral, antiaging, anticancer, immunomodulatory and anti-inflammatory effects

Visit Mercola Market


Melatonin, well-known for its role in regulating your body’s circadian rhythm, is useful for far more than a good night’s sleep. This hormone was recently heralded for its role in eye health, and it may be an important compound for warding off age-related declines in vision.

Glaucoma, for instance, is among the leading causes of blindness, affecting 70 million people throughout the world. While its underlying causes are unknown, mechanical stress caused by elevated intraocular pressure (IOP) is known to damage retinal ganglion cells.

It’s been suggested that glaucoma is, in fact, a neurodegenerative disease, and damage to retinal ganglion cells affects not only vision but also circadian rhythms and sleep. People with glaucoma may have disrupted circadian rhythms compared to their peers,

and neuroprotective strategies that prevent damage to retinal ganglion cells could help with both this and glaucoma. In this regard, melatonin checks all the boxes.

In a study published in the Journal of Pineal Research, a team of scientists investigated the effects of melatonin supplements on patients with glaucoma.

Subjects took melatonin daily at 10:30 p.m. for 90 days, experiencing a number of benefits, including:

  • Increased stability of systemic circadian rhythm via improved phase alignment and alignment with intraocular pressure

  • Decreased intraocular pressure

  • Improved function of retinal ganglion cells in those with advanced glaucoma

  • Improvements to sleep and mood, particularly in those with advanced glaucoma

Previous research by the team found that melatonin was beneficial for disrupted systemic circadian rhythms and the cardiovascular system.

They explained:

“Being a principal chemical factor for sensing environmental light signaling and synchronizing peripheral clocks, melatonin serves both input and output of the circadian system. Melatonin is regarded as a promising substance to ameliorate complex glaucoma-associated conditions of compromised well-being (i.e., disrupted circadian rhythms, altered sleep and mood).

… Combined, these results provide evidence for melatonin efficiency in restoring disrupted circadian rhythms in glaucoma, with different effects of melatonin on systemic vs. local rhythms, suggesting that a personalized strategy for melatonin administration may further refine its benefits.”

Melatonin is often described as a pineal hormone,

but only 5% of your body’s melatonin — which is also a potent anticancer agent — is produced in your pineal gland. The other 95% is produced inside your mitochondria — provided you get proper sun exposure, which is intricately involved in melatonin production.

Meanwhile, melatonin receptors exist in several areas of the eyes, including the retina, lens and cornea, “which suggests that cells in these tissues may be targets for melatonin action,” researchers wrote in Pharmacology & Therapeutics.

This hints at melatonin’s importance for regulating eye processes, particularly when “pressure homeostasis” is involved. Writing in Progress in Retinal and Eye Research, scientists with the University Complutense of Madrid, Spain, explained:

“Glaucoma, the most prevalent eye disease, also known as the silent thief of vision, is a multifactorial pathology that is associated to age and, often, to intraocular hypertension (IOP). Indeed IOP is the only modifiable risk factor and as such medications are available to control it; however, novel medications are sought to minimize undesirable side effects.

Melatonin and analogues decrease IOP in both normotensive and hypertensive eyes. Melatonin activates its cognate membrane receptors, MT1 and MT2, which are present in numerous ocular tissues, including the aqueous-humor-producing ciliary processes.

Melatonin receptors belong to the superfamily of G-protein-coupled receptors and their activation would lead to different signaling pathways depending on the tissue … the current work highlights the important role of melatonin and its analogues in the healthy and in the glaucomatous eyes, with special attention to the control of intraocular pressure.”

Further, the effect of melatonin on intraocular pressure has been known for decades. In 1988, researchers with Oregon Health Sciences University exposed subjects to bright light, in order to suppress serum melatonin levels, and then supplementing with melatonin to gauge its effect on intraocular pressure.

A significant connection was found:

“Our data suggests that during the period of melatonin’s greatest levels in the serum, IOP is lowest. All subjects had maximum pressures form 4 p.m. to 6 p.m. and most subjects had minimums from 2 a.m. to 5 a.m. In experiment one, bright light suppression of melatonin secretion attenuated the early morning fall IOP. This was statistically significant at suggesting that melatonin is involved in lowering early morning IOP.

In experiment one, there was only partial suppression of melatonin production with bright light and consequently there was no significant difference in IOP between subjects exposed to dim light and bright light. However, administering 200 micrograms of melatonin orally caused a significant decrease in IOP. Intraocular pressure remained low for approximately four hours after the last dose.”

Melatonin appears to have far-reaching effects on eye health, even beyond glaucoma. Cataracts, for instance, are associated with oxidative stress, and research suggests melatonin counteracts oxidative damage in the lens and may be a “potential therapeutic agent for cataract prevention/management.”

Melatonin may also be useful for neurovascular age-related macular degeneration (AMD), which is characterized by abnormal angiogenesis in the retina and leads to severe vision loss in more than 90% of those affected. The compound inhibits endothelial progenitor cell angiogenesis and neovascular AMD.

According to a study published in the journal Cells:

“The promotion or inhibition of angiogenesis is part of the homeostatic balance, with positive and negative effects outside the optimum range. Melatonin influences this balance, with evidence from several clinical research investigations demonstrating that this hormone has antiangiogenic effects in cancer and chronic ocular diseases.”

Animal studies also suggest that melatonin protects the retina in dry AMD, while anecdotal reports suggest “favorable” experiences among adults with AMD who supplemented with melatonin.

One study suggested melatonin in a dose of 3 to 20 milligrams at bedtime may be useful for controlling dry AMD.

There’s a mitochondrial component as well, as impaired mitochondrial biogenesis is found in human retinal cells affected by AMD — and melatonin is a potential treatment. Researchers explained in Expert Opinion on Therapeutic Targets:

“During aging, insufficient free radical scavenger systems, impairment of DNA repair mechanisms and reduction of mitochondrial degradation and turnover contribute to the massive accumulation of ROS [reactive oxygen species] disrupting mitochondrial function. Impaired mitochondrial function leads to the decline in the autophagic capacity and induction of inflammation and apoptosis in human RPE cells affected by AMD.”

Importantly, they noted, “The effect of melatonin on mitochondrial function results in the reduction of oxidative stress, inflammation and apoptosis in the retina; these findings demonstrate that melatonin has the potential to prevent and treat AMD.”

In the human body — aside from having direct antioxidant effects — melatonin stimulates the synthesis of glutathione and other important antioxidants like superoxide dismutase and catalase.

Melatonin increases glutathione through a genomic effect on the enzyme that regulates the synthesis of gamma glutamylcysteine synthetase, the rate limiting enzyme in glutathione synthesis. Melatonin activates that enzyme.

Glutathione tends to be found in high concentrations in cells, although some is also found in the extracellular space and the mitochondria. Melatonin’s antioxidant effects are diverse but include preventing free radical generation by enhancing the efficiency of the electron transport chain so fewer electrons leach onto oxygen molecules to generate super oxide antiradical.

Melatonin also has antiviral and anti-inflammatory effects, and more than 140 scientific studies suggest it’s a useful agent for treating SARS-CoV-2, according to research published in Cellular and Molecular Life Sciences.

One reason why melatonin works as an anti-COVID-19 agent is due to its role against sepsis (blood poisoning). Melatonin has prevented death in newborns suffering from severe bacterial sepsis

and also appears to reverse septic shock symptoms by:

  • Decreasing synthesis of proinflammatory cytokines

  • Preventing lipopolysaccharide (LPS)-induced oxidative damage, endotoxemia and metabolic alterations

  • Suppressing gene expression of the bad form of nitric oxide, inducible nitric oxide synthase (iNOS)

  • Preventing apoptosis (cell death)

Melatonin also plays an important role in cancer prevention, with “significant atoxic, apoptotic, oncostatic, angiogenetic, differentiating and antiproliferative properties against all solid and liquid tumors.”

It exerts “both direct and indirect anticancer effects,”

in part due to its antioxidant and immunomodulatory effects. Melatonin is also thought to be important for brain, cardiovascular and gastrointestinal health.

For certain eye conditions, there may be benefits to supplementing with oral melatonin. However, it’s also a good idea to optimize your body’s own production, which you can do naturally. Optimizing melatonin production begins with getting enough bright sunlight during the day since this helps to set your circadian clock.

Aim for at least 15 minutes of sunlight in the morning hours helps to regulate the production of melatonin, dropping it to normal daytime levels, so you feel awake during the day and sleep better at night. Ideally you should have sunlight on your bare skin as that will help the near IR in the sunlight activate your mitochondria to produce melatonin. About 95% of your melatonin is produced this way which is why you want the sunlight on your skin.

As evening approaches and the sun sets, you’ll want to avoid artificial lighting. Blue light from electronic screens and LED lights is particularly problematic and inhibits the production of melatonin. If you do need lighting, use incandescent light bulbs, candles or salt lamps.

The blue light from electronic screens can be counteracted by using blue blocking software or wearing blue blocking glasses. You should also sleep in complete darkness at night, as even light that shines through closed eyelids can suppress melatonin.

If your bedroom isn’t pitch-black at bed time, consider wearing a sleep mask.

Engaging in stress-reducing activities, such as stretching or meditation, before bed may also be useful. This is because the release of melatonin is dependent on the release of another hormone, norepinephrine.

Excess stress, and the resulting release of cortisol, will inhibit the release of norepinephrine and therefore the release of melatonin.

So in addition to stress-reduction techniques, try to limit stressful activities — like work projects — in the evening hours.

Subscribe to Mercola Newsletter

Disclaimer: The entire contents of this website are based upon the opinions of Dr. Mercola, unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked.

The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Mercola and his community. Dr. Mercola encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. The subscription fee being requested is for access to the articles and information posted on this site, and is not being paid for any individual medical advice.

If you are pregnant, nursing, taking medication, or have a medical condition, consult your health care professional before using products based on this content.