This Gel Stops Brain Tumors After Surgery, Offering Hope for Glioblastoma Cancer Patients

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Johns Hopkins / SWNS

Medication delivered by a novel gel cured 100% of mice with an aggressive brain cancer, a striking result that offers new hope for patients diagnosed with glioblastoma, one of the deadliest and most common brain tumors in humans.

“We think this hydrogel will be the future,” said study leader Professor Honggang Cui of Johns Hopkins University.

Cui’s team combined an anticancer drug and an antibody in a solution that self-assembles into a gel to fill the tiny grooves left after a brain tumor is surgically removed.

The gel can reach areas that surgery might miss and current drugs struggle to reach to kill lingering cancer cells and suppress tumor growth.

The gel also seems to trigger an immune response that a mouse’s body struggles to activate on its own when fighting glioblastoma.

When the researchers re-challenged surviving mice with a new glioblastoma tumor, their immune systems alone beat the cancer without additional medication. The gel appears to not only fend off cancer but help rewire the immune system to discourage recurrence with immunological memory, researchers said.

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Still, surgery is essential for this approach, the researchers said. Applying the gel directly in the brain without surgical removal of the tumor resulted in just a 50% survival rate.

“The surgery likely alleviates some of that pressure and allows more time for the gel to activate the immune system to fight the cancer cells,” Prof. Cui said.

The gel solution consists of nano-sized filaments made with paclitaxel, an FDA-approved drug for breast, lung, and other cancers. The filaments provided a vehicle to deliver the antibody called aCD47. By blanketing the tumor cavity evenly, the gel releases medication steadily over several weeks, and its active ingredients remain close to the injection site.

By using that specific antibody, the team is trying to overcome one of the toughest hurdles in glioblastoma research. It targets macrophages, a type of cell that sometimes supports immunity but other times protects cancer cells, allowing aggressive tumor growth.

MORE WINS: New Brain Cancer Immunotherapy Shows Promise in Human Trial – Most Patients Saw No Tumor Growth

The results are published in Proceedings of the National Academy of Sciences.

One of the go-to therapies for glioblastoma is a wafer co-developed by a team of researchers at Johns Hopkins and the Massachusetts Institute of Technology in the 1990s, commercially known as Gliadel. It is an FDA-approved, biodegradable polymer that also delivers medication into the brain after surgical tumor removal.

Gliadel showed significant survival rates in laboratory experiments, but the results achieved with the new gel are some of the most impressive the Johns Hopkins team has seen, said Betty Tyler, a co-author and associate professor of neurosurgery at the Johns Hopkins School of Medicine who played a pivotal role in the development of Gliadel.

“We don’t usually see 100% survival in mouse models of this disease,” Tyler said. “Thinking that there is potential for this new hydrogel combination to change that survival curve for glioblastoma patients is very exciting.”

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The new gel offers hope for future glioblastoma treatment because it integrates anticancer drugs and antibodies, a combination of therapies researchers say is difficult to administer simultaneously because of the molecular composition of the ingredients.

“The gel is implanted at the time of tumor resection, which makes it work really well,” Tyler said.

The challenge now is to translate the gel’s results in the lab into therapies with substantial clinical impacts.

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Lager Beer, the World's Favorite, was Invented By Accident 400 Years Ago When 2 Yeasts Walked into a Bar – Study

lager-beer,-the-world's-favorite,-was-invented-by-accident-400-years-ago-when-2-yeasts-walked-into-a-bar-–-study
lucas Oliveira

Lager is the world’s most popular beer, and new research shows it was invented by accident more than 400 years ago in Bavaria.

The yeast that is currently used to brew cold beer originated in Munich, at the court of Maximilian the Great, after two different yeasts came into contact and mated.

Their coupling created the new species Saccharomyces pastorianus, which works at a much slower rate and at cooler temperatures in caves and cellars.

For thousands of years, all beers were fermented with the particular strain named Saccharomyces cerevisiae. It ferments warm and relatively quickly – producing what we refer to as ale. Evidence of fermented beverages from China date back at least 7,000 years ago, and from Israel up to 13,000 years ago.

In a new study, a microbiologist at the Technical University of Munich explained that lager uses S. pastorianus, which is responsible for the production of bottom-fermented lagers.

“It is a hybrid that arose from the mating of the top-fermenting ale yeast Saccharomyces cerevisiae and the cold-tolerant Saccharomyces eubayanus around the start of the 17th century,” said lead author Dr. Mathias Hutzler.

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For their study published in FEMS Yeast Research, the team combined documents with evolutionary and genetic data to trace the beverage’s origins to the Munich brewery of the Duke of Bavaria in 1602.

The mingling

They found S. cerevisiae (the most common yeast used in European brewing at the time, which produced ale) had contaminated a batch of beer brewed with the wild variant S. eubayanus at a wheat brewery in the small town of Schwarzach in southern Germany.

The paler beers that today are the most popular in the world are the lagers, like Heineken, Miller, and Corona—and researchers sought to understand the historical shift from ale to lager in Europe.

The mystery of the lager yeast’s parentage was solved in 2011, when S. eubayanus was discovered in the Patagonian Andes in Argentina.

The new study shows S. pastorianus developed in three stages. First, the yeast strain S. cerevisiae came to Munich from Bohemia, where brewers had made wheat beer since at least the 14th century—it’s the same species that is still used today to make ale-style beer, wine, and bread.

Then, in a Munich brewery in 1602, it mated with S, eubayanus, which was also involved in making beer, giving rise to S. pastorianus.

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The new species of yeast was distributed around Munich breweries first, and then throughout Europe and the world. Lager now accounts for approximately 90 percent of the beer consumed annually.

According to Dr. Hutzler, no one had figured out how S. pastorianus came about, until now.

LIFT YOUR GLASS–By Sharing This Discovery With Beer-Lovers on Social Media…

Guy on Pub Crawl Dressed as Gandalf Bumps into ‘Real’ Ian McKellen For Best Birthday Surprise Ever

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Ben Coyles with Sir Ian McKellen – SWNS

A man celebrating his birthday dressed as Gandalf from Lord of the Rings was on a pub crawl when he suddenly bumped into Sir Ian McKellen.

Tolkien super-fan Ben Coyles was out marking his 22nd birthday when he ran into the iconic British actor who played the part.

McKellen, who portrayed Gandalf the wizard in the blockbuster film trilogy, The Lord of the Rings (and The Hobbit), was in the English city of Bristol for a stage role.

Ben was walking to the next celebratory bar with a group of friends on April 13 when they turned onto Corn Street and saw the Oscar-nominated man himself.

Almost in shock, Ben’s friends managed to take a couple photos for him featuring his hero.

“We had no idea he would be there,” said Felix Spencer. “We were on our penultimate pub when someone comes up and asks if we would like our Gandalf to meet the real Gandalf.

“So I turn around and assume it’s going to be someone pulling my leg but when I turn round Sir Ian McKellen is right there.

A few of Ben’s friends knew he was in town—performing in Mother Goose at the Bristol Hippodrome on April 14th with comedian John Bishop—but they never imagined bumping into him.

Ben Coyles with Sir Ian McKellen – SWNS

“So, it was really bizarre,” said Ben, a music student at the University of Bristol. “I didn’t recognize him immediately, then I was like ‘OH MY GOD, IT’S SIR IAN MCKELLEN!’

“Everybody said ‘what on earth is going on?!’

“He asked me how old I was, and said ‘happy birthday’, and shook my hand.

“I was flabbergasted, I had no idea what to do or say.

“We had zero idea that he was walking down that street.

“He’s a really lovely bloke, an excellent guy, nice, down to earth and humble and I’d like to buy him a drink.

RELATED: ‘Lord of the Rings’ Cast is Crowdfunding to Buy J.R.R. Tolkien’s Home And Dedicate it to Fans

“If I was 10-20 meters ahead of him it wouldn’t have happened—the planets aligned.”

SEND Some Whimsy to Wizarding Fans on Social Media–SHARE the Moment…

Revolutionary Music Therapy Helps Paralyzed Man Walk and Talk Again–Singing and Hearing ‘Unlocked the Brain’

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A patient who was left almost completely paralyzed from a rare disease is now walking and talking again, after a music therapist prescribed mindful listening to his favorite song every night—in this case, a tune by The Carpenters.

71 year-old Ian Palmer was struck down with Guillain-Barré syndrome last June, forcing him to spend seven months in a hospital where he was unable to walk or speak properly. The rare condition happens when a person’s own immune system attacks their body’s motor nerves, causing muscle weakness and sometimes paralysis.

“It selectively targets the motor nerve cells and you have to wait for them to regenerate—which in your 70s is quite worrying!”

“I was in intensive care, being suctioned 24 hours a day, as I couldn’t swallow, and this was leading to choking problems, and I had a nasogastric tube fitted for over four months.”

Ian’s speech was affected by the syndrome because it caused damage to his larynx, the tunnel in the back of the throat where air passes through to create sounds.

But when Ian was transferred to Sue Ryder Neurological Care Centre, a state-of-the-art care unit in Lancashire, England, clinicians used music therapy techniques to overcome ‘near total paralysis of his body’.

His specialist, Clare, taught him mindfulness techniques using his favorite records—and he began listening to The Carpenters each night.

Ian Palmer with his music therapist, Clare – SWNS

Ian was admittedly skeptical, but he can now walk 2 miles a day (3k) and have conversations with his family after the exercises “opened up” his brain.

He’s never been very musical, so when Sue Ryder first suggested music therapy he said, ‘What good is that going to do?’

“I’m a typical Northern man, and I thought, ‘What’s a girl with a guitar going to do for me—get me to the gym.’”

“But it really worked. Clare sat me down and explained the process. I learned that music is very unlike other therapies, as it opens up all of the brain.”

She taught Ian to sing a long note using his diaphragm to assist.

“I told her, ‘I don’t even know where that is!’ But, she explained that by calling on the diaphragm, you’re training the brain so that it can use other muscles too.

“It learns the pathways and reopens them.”

CHECK OUT: The Lullaby Project Connects Mothers Behind Bars with Their Babies, Helping Them Write Original Lullabies

Clare also got Ian to practice mindfulness techniques, with some assistance from his favorite records.

“She wanted something I could relax to, and being of a certain age, The Carpenters was my choice. She asked me to do it before bed, and now I put The Carpenters on every night.

“She told me to push away the thoughts, and just focus on the music.

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Ian, who has since been discharged from the clinic, which also has locations around England and Scotland, said he was amazed at the difference music therapy had made to his experience.

“One of my goals was to walk through my front door. Now I can take my headphones and go for a walk doing my vocal exercises. There’s been such a positive impact.”

Using his diaphragm, he also learned how to breathe more effectively.

“My mum couldn’t understand me when she first came to visit. But now I’m confident that the music therapy I’ve received has more than dealt with it, and my voice has been able to join the rest of my body in recovering.”

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And there might not have been a better a song choice than We’ve Only Just Begun

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Proof: The FDA knew on September 17, 2021 that people who got the COVID vaccine were 2X more likely to be infected

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Most people didn’t read the September 17, 2021 FDA briefing document so let me highlight the top of page 22 for you. With a little simple math (shown here), it’s clear that you are 2X more likely to be infected during the time you are vaccinated. The p-value is <.001. This was not just a fluke. It was validated in the Cleveland Clinic study.

The Cleveland Clinic study, which I fully explain in this article, shows that the more vaccines you get, the more likely you are to be infected with COVID.

This was not a fluke. As I pointed out in my article, the results were consistent with three other large studies, two of which (the Qatar and Pfizer studies) were general population and not just healthcare workers.

One of the two large confirming studies was the Pfizer Phase 3 trial participants themselves.

Did you know that Pfizer told the FDA in a document dated September 17, 2021 that people who were on the vaccine for a longer period were more likely to be infected with COVD than those who spent only about half the time in the vaccinated state. The difference between the infection rates of the vaxxed vs. unvaxxed was more than 2X. See this section of my article for details on data in the FDA document and the simple calculation to determine the relative infection rates.

The bottom line is that the FDA knew on Sept 17, 2021 that you were more likely to be infected with COVID if you were vaccinated. That’s the opposite of what they told us.

We need to acknowledge our mistakes and take corrective action.

Every business who has a vaccine mandate should immediately issue a reverse mandate.

For example,

  1. Hospitals should immediately fire anyone who is vaccinated with the COVID vaccine. Proof of being unvaccinated should be required to keep your job. Religious and medical exemptions should be honored so if anyone’s religious beliefs require them to be vaccinated, those people should be accommodated. Similarly, if anyone has a medical condition requiring them to be vaccinated, they should be given an exemption.

  2. College campuses should not allow students who are vaccinated to enroll. In addition, all visitors to campus will need to show proof of unvaccination. In short, if you are vaccinated, you should no longer be allowed on campus.

  3. Proof of unvaccination should be required to enter restaurants and attend public gatherings.

  4. If you are not an American citizen, you should not be able to enter the US without proof of unvaccination.

  5. Unvaccination should be required to hold elective office.

  6. All emergency personnel (police, fire, paramedics) must be unvaccinated or face losing their job.

  7. All doctors who advised their patients to get vaccinated should have their license to practice medicine revoked by the medical boards. Their board certifications and hospital privileges should be removed as well. After all, these physicians are a danger to society because they lack the ability to think for themselves and do what is best for their patients.

  8. Doctors who write vaccine prescriptions for the COVID vaccine shall be investigated and may have their license to practice medicine revoked. After all, the COVID vaccine isn’t justifiable for any patient so you must be a very bad doctor who doesn’t believe in evidence-based medicine.

  9. Other than as noted above, there should be no tolerance for the vaccinated. These people should have known better. They are a risk to society and prevent us from getting to herd immunity. They should be ostracized and excluded from all family events moving forward.

In short, it’s time to turn the tables around.

How To Turn The Tables On The Interviewers Trying To Turn The Tables On You

It’s time to turn the tables around and discriminate against all vaccinated people.

At this point, there is absolutely no doubt that COVID vaccination increases your risk of infection. Everyone who tries to attack the Cleveland Clinic study has failed. Nothing sticks.

Many of my readers have validated this effect with their own eyes and often write in comments like it’s all their vaccinated friends getting sick with COVID. And those turbo cancers, amyloid clots, and sudden deaths are happening almost exclusively in the vaccinated (or if you got a transfusion).

Wayne Root’s statistics are another great anecdote that should be impossible if the vaccines are so safe. Nobody’s been able to explain his numbers. Basically, Wayne found that his vaccinated friends were dying or had severe side effects in large numbers while his unvaccinated friends were unaffected.

And where is the anti-Wayne Root anecdote where it is just the unvaxxed who are getting very sick and dying? I still can’t find such an anecdote. I’ve tried.

Why can’t I find a single anecdote of a nursing home where the all-cause death rate declined after the vaccine rolled out?

If you listened to the CDC and mainstream media, you were led to believe that the unvaccinated would all be extinct by now.

So now that nobody can attack the Cleveland Clinic data, isn’t it time to right this wrong and reverse the mandates?

How about we now give the vaccinated a taste of their own medicine so they will understand first hand what it feels like to be unfairly penalized for doing nothing more than following the science?

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