Original Antigenic Sin — The Hidden Danger of COVID Shots

  • Scientists warn repeated COVID boosters may result in lowered immunity through a process known as “original antigenic sin” or “immune imprinting”

  • Original antigenic sin describes how your first exposure to a virus shapes the outcome of subsequent exposures to antigenically related strains. The end result is that you become increasingly prone to symptomatic infections

  • Data from the U.S. Centers for Disease Control and Prevention confirm that people who got two or three COVID jabs are MORE likely to get ill with COVID six to eight months after the last dose than had they gotten none

  • Health authorities are potentially worsening matters further by pushing people to simultaneously get the updated bivalent COVID booster and a quadrivalent flu vaccine this fall

  • The COVID jab and the flu vaccine are the No. 1 and No. 2 most dangerous injections respectively, based on adverse event reports and payouts from the U.S. Vaccine Injury Compensation Program. Both are also capable of shedding, and both can make you more prone to infection as their protection wears off

Visit Mercola Market

Advertisement

COVID-19 has been going on for nearly three years, and with a whole new set of untested COVID boosters being rolled out, some scientists are taking a step back, cautioning that there still are unanswered questions about how the shots work.

They say more research needs to be done on what is known as “original antigenic sin,” aka “immune imprinting,” which refers to how your immune system responds to repeated introductions of the COVID variants.

The following description of original antigenic sin was published in a January 2019 Journal of Immunology paper titled “Original Antigenic Sin: How First Exposure Shapes Lifelong Anti–Influenza Virus Immune Responses”:1

“The term ‘original antigenic sin’ (OAS) was first used in the 1960s to describe how one’s first exposure to influenza virus shapes the outcome of subsequent exposures to antigenically related strains. In the decades that have passed, OAS-like responses have been shown to play an integral role in both protection from and susceptibility to infections.

OAS may also have an important deterministic role in the differential efficacy of influenza vaccine responses observed for various age cohorts across seasons …

OAS describes the phenomenon whereby the development of immunity against pathogens/Ags is shaped by the first exposure to a related pathogen/Ag … subsequent infections with similar influenza virus strains preferentially boost the Ab response against the original strain …

The critical role of primary exposure in shaping the composition of the Ab repertoire was not only observed in humans after influenza virus infections; this phenomenon was also observed in animal models and in the context of other infectious agents.

For example, additional serum absorption experiments in ferrets infected in succession with three different influenza virus strains demonstrated that nearly all of the host Abs after the infection series were reactive against the first strain, only a fraction of serum Abs could be absorbed by the secondary virus, and fewer yet by the tertiary virus.”

Here’s a layman’s summary to illustrate this phenomenon as simply as possible, within the context of COVID:

  • Exposed to the original Wuhan SARS-CoV-2 strain, your humoral immune system is programmed to produce antibodies against that specific virus. Similarly, if you got the jab, your body will produce antibodies against the viral spike protein formulated into that shot.

  • Exposed to the Delta strain, your immune system responds first by boosting production of the original antibodies, while antibodies specific against Delta are produced in a far lower amount as it takes time for your body to respond to the new strain.

  • Exposed to an Omicron variant, your immune system again responds by boosting the original antibodies, while antibodies against Omicron are produced in even lower amounts than those against Delta.

As a result of this process, with each exposure to a new variant, the original antibodies get “back-boosted.” So, over time, those antibodies come to predominate.

The process is (at least theoretically) the same for all vaccinations. Each booster dose back-boosts or strengthens the original antibodies, making them more and more predominant. The problem is that they may not be effective at neutralizing newer strains (depending on the amount of mutation), thus rendering you more and more prone to symptomatic infection.

As reported by ABC News:2

“Some experts say they are concerned that frequent boosting with the original version of the vaccine may have inadvertently exacerbated immune imprinting. At this point in the pandemic, some adults have received four or more doses of the same vaccine …

[Some] scientists worry about a potential backfire, with frequent boosting handcuffing the body’s natural immune system and leaving it exposed to radically different variants that might emerge in the future.

‘Where this matters is if you keep giving booster doses with [original] strain, and continue to lock people into that original response. It makes it harder for them to respond then to essentially a completely different virus,’ says Dr. Paul Offit, professor of pediatrics at Children’s Hospital Philadelphia …

The timing of vaccines may also need to be taken into account, as the nation moves from original doses to updated boosters.

‘It is true that the best boosts typically are the ones that are given infrequently, that immunologically, if you boost too much and too frequently, then you often have a lower immune response at the end,’ said [director of the center for virology and vaccine research at Beth Israel Deaconess Medical Center, Dr. Dan] Barouch.”

In the video above, Dr. Meryl Nass reviews official data from the U.S. Centers for Disease Control and Prevention, which confirm that people who got two or three COVID jabs are MORE likely to get ill with COVID six to eight months after the last dose than had they gotten none.

Our reckless health authorities are potentially worsening matters further by pushing people to simultaneously get the updated bivalent COVID booster and a seasonal flu vaccine this fall.

Early in September 2022, White House medical adviser Dr. Anthony Fauci urged Americans to “Get your updated COVID-19 shot as soon as you are eligible,” and White House COVID coordinator Ashish Jha, September 6, stated, “I really believe this is why God gave us two arms, one for the flu shot and the other one for the COVID shot” — a statement that will live on in infamy as one of the most ridiculous comments from a public health official ever uttered.3

One problem, although hardly the most important one, is that it’s still far too early for a flu shot. As noted by STAT News:4

“The protection generated by influenza vaccines erodes pretty quickly over the course of a flu season. A vaccine dose given in early September may offer limited protection if the flu season doesn’t peak until February or even March, as it did during the unusually late 2021-2022 season.

‘If you start now, I am not a big fan of it,’ Florian Krammer, an influenza expert at Mount Sinai School of Medicine in New York, told STAT. ‘I understand why this is promoted, but from an immunological point of view it doesn’t make much sense.’”

STAT cites research showing the effectiveness of the flu shot wanes by about 18% for every 28 days’ post-vaccination. What it doesn’t mention is the fact that the flu shot historically has had an effectiveness well below 50% to start with. The 2018/2019 flu vaccines, for example, which outperformed the 2017/2018 vaccines, had an adjusted effectiveness rating of:5

  • 29% for all ages

  • 49% for children aged 6 months through 8 years

  • 6% for children ages 9 through 17

  • 25% for adults between the ages of 18 and 49

  • 12% for those over 50

Ever since the rollout of the COVID shots, there have been suspicions that some kind of shedding is happening between the jabbed and the unjabbed.6 With mass flu vaccination, the possibility of transmission is further exacerbated, and there’s no telling what kind of viral mutations the combination of a bivalent COVID jab and a quadrivalent flu shot might produce.

A study7 published January 18, 2018, in the journal PNAS showed that people who receive the seasonal flu shot and then contract influenza excrete infectious influenza viruses through their breath.

What’s more, those vaccinated two seasons in a row had a greater viral load of shedding influenza A viruses. According to the authors, “We observed 6.3 times more aerosol shedding among cases with vaccination in the current and previous season compared with having no vaccination in those two seasons.”

This study also highlighted the possibility that annual flu vaccination might lead to reduced protection against influenza over time, and that each vaccination can make you progressively more prone to getting sick. That, again, is the original antigenic sin phenomenon discussed above.

Now, combine the possibility of antigenic sin for COVID with the antigenic sin for influenza, and what might we end up with? Who knows? Research8 has also shown that priming your immune system with influenza vaccine can make you more susceptible to bacterial infections as well, and what are face masks loaded with? Bacteria.

Taken together, we could well be facing the “dark winter” president Biden warned would befall the unvaccinated last year. But it’ll be those with COVID booster and quadrivalent flu shots who will suffer the most. The rest of us will hopefully avoid problems provided we keep our immune systems strong.

On top of the antigenic sin possibility for both the COVID jab and the flu vaccine, there’s the possibility of suffering serious side effects from either or both of these shots. Before the advent of the COVID jab, injury following influenza vaccination was the most compensated claim in the federal Vaccine Injury Compensation Program (VICP).

Between January 1, 2006, and December 31, 2019, a total of 5,407 injury claims for flu vaccine were filed, 4,614 of which were compensated.9 Based on VICP injury filings and awards, the flu vaccine was the riskiest vaccine out there. The COVID jab, however, blew the flu shot out of the water within the first few weeks of use.

“This fall, they’re telling people to line up for the two riskiest and deadliest injections out there. Media are stating that getting the flu shot and the COVID jab at the same time is ‘safe.’ Yet there are absolutely NO data to support such a claim.”

As of September 2, 2022, just 21 months into the COVID jabs existence, 1,400,350 post-jab injuries have been reported to the Vaccine Adverse Event Reporting System (VAERS).10 That’s more than half of all VAERS reports collected for all vaccines since its inception 32 years ago.

So, this fall, they’re telling people to line up for the two riskiest and deadliest injections out there. In my view, this is reckless beyond belief, and I would caution against this strategy. Disturbingly, media are stating that getting the flu shot and the COVID jab at the same time is “safe.”11 Yet there are absolutely NO data to support such a claim. It’s pure assumption.

The fact that the COVID jabs can cause serious side effects is evident by VAERS data alone, but studies reanalyzing original trial data submitted to the U.S. Food and Drug Administration are also starting to emerge that confirm the riskiness of these shots.

Most recently, a study12 13 in the journal Vaccine concluded the Pfizer and Moderna COVID jabs are associated with a 16% “excess risk of serious adverse events of special interest” over placebo baseline, on average. As detailed in that paper:14

“In 2020, prior to COVID-19 vaccine rollout, the Brighton Collaboration created a priority list, endorsed by the World Health Organization, of potential adverse events relevant to COVID-19 vaccines. We adapted the Brighton Collaboration list to evaluate serious adverse events of special interest observed in mRNA COVID-19 vaccine trials.

Methods: Secondary analysis of serious adverse events reported in the placebo-controlled, phase III randomized clinical trials of Pfizer and Moderna mRNA COVID-19 vaccines in adults … focusing analysis on Brighton Collaboration adverse events of special interest.

Results: Pfizer and Moderna mRNA COVID-19 vaccines were associated with an excess risk of serious adverse events of special interest of 10.1 and 15.1 per 10,000 vaccinated … respectively. Combined, the mRNA vaccines were associated with an excess risk of serious adverse events of special interest of 12.5 per 10,000 vaccinated …

The Pfizer trial exhibited a 36 % higher risk of serious adverse events in the vaccine group; risk difference 18.0 per 10,000 vaccinated … The Moderna trial exhibited a 6 % higher risk of serious adverse events in the vaccine group: risk difference 7.1 per 10,000 …

The excess risk of serious adverse events found in our study points to the need for formal harm-benefit analyses, particularly those that are stratified according to risk of serious COVID-19 outcomes. These analyses will require public release of participant level datasets.”

In an open letter addressed to the CEOs of Pfizer and Moderna published in The BMJ,15 the authors of this Vaccine paper call for the release of all clinical data, including individual participant data, so that a more thorough reanalysis can be made:

“The effort to prepare these datasets is minimal, and no potentially identifying data is needed … Today (Aug 31), our study of serious adverse events in the Pfizer and Moderna phase 3 COVID-19 vaccine trials was published in the peer-reviewed journal Vaccine.

The results showed the Pfizer and Moderna both exhibited an absolute risk increase of serious adverse events of special interest (combined, 1 per 800 vaccinated), raising concerns that mRNA vaccines are associated with more harm than initially estimated at the time of emergency authorization.

We acknowledge that our estimates are only approximations because the original data remain sequestered. For example, we could not stratify by age, which would help clarify the populations in which benefits outweigh harms.

A more definitive determination of the actual harms and benefits requires individual participant data (IPD) that remain unavailable to research investigators … COVID-19 vaccines are now among the most widely disseminated medicines in the history of the world.

Yet, results from the pivotal clinical trials cannot be verified by independent analysts. The public has a legitimate right to an impartial analysis of these data …

Transparency, reproducibility, and replication are cornerstones of high-quality science. The time is overdue for Pfizer and Moderna to allow independent scientists and physicians to see the original data and to replicate the analyses.”

The COVID shots also appear to be responsible for the rapid increase in excess deaths around the world. As reported September 8, 2022, by The Defender,16 the COVID jabs are causing injuries on a scale we’ve never seen before in medical history.

Yet governments around the world are turning a blind eye. Most medical researchers also avoid these data like the plague, for fear of getting defunded. Two university professors in Germany, however, have bucked that trend.

Psychologist Christof Kuhbandner and Matthias Reitzner, a statistician, analyzed excess mortality data from the German Federal Statistical Office (Bundesamt für Statistik) for 2020 through August 2022.17 18

By applying actuarial analysis to the all-cause mortality data — i.e., by estimating the number of all-cause deaths during these years had there been no pandemic, and then comparing that to the observed all-cause deaths — they found the death toll in 2020, at the height of the pandemic, was actually close to the expected number.

In 2021, however, the observed number of deaths were “two empirical standard deviations above the expected number.” What’s more, the increase in mortality only started to accumulate after April that year. A similar pattern was also observed for stillbirths, which rose by 11% in the second quarter of 2021.

The figure below illustrates the differences in excess mortality between 2020, the year of the virus, and 2021, the year of the COVID jabs.19 20 Looking at the age groups, we see something very odd. In 2021, excess mortality was highest among 15- to 79-year-olds, yet COVID infection primarily killed the elderly, 70 to 79 years of age, in 2020.

Mortality in age groups 15 to 29, and 50 to 59, during the pandemic, pre-jab, was actually below average, and excess mortality among children was well below average. Yet in 2021, excess mortality went up for all age groups, not just the elderly. This strongly suggests the COVID virus was not a primary contributor, but rather the experimental injections.

Kuhbandner and Reitzner further notes there were spikes in excess mortality in April and May and again in September, November and December 2021. The April/May spike coincides with the COVID shot rollout in Germany, and the increases in the fall correlate with booster campaigns.

The following graph21 22 illustrates how tightly connected the excess mortality numbers are with the rise and fall in COVID shots administered.

In my view, there’s simply no doubt the COVID jabs are causing more harm than good, and combining a reformulated and never tested bivalent COVID booster with a quadrivalent flu shot could potentially be disastrous.

Subscribe to Mercola Newsletter

Disclaimer: The entire contents of this website are based upon the opinions of Dr. Mercola, unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked.

The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Mercola and his community. Dr. Mercola encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. The subscription fee being requested is for access to the articles and information posted on this site, and is not being paid for any individual medical advice.

If you are pregnant, nursing, taking medication, or have a medical condition, consult your health care professional before using products based on this content.

The Average Person Has at Least 4 Health Issues

  • The average adult is battling at least four different health issues, such as back pain, headaches and seasonal allergies

  • Not only did 82% of the adults surveyed have a minor health condition, but 59% said they were in “significant” pain or discomfort

  • A significant number of those with multiple health conditions have trouble sleeping, have developed related mental health conditions and can’t work as a result

  • More than half of U.S. adults regularly take prescription medications, and the average adult takes four, increasing the risk of adverse drug reactions

  • Many chronic health conditions and mental health problems can be remedied with healthy lifestyle changes

Visit Mercola Market

Advertisement

If you’re currently healthy, count yourself lucky — and above average when it comes to the average adult battling at least four different health issues. The disturbing data was revealed by OnePoll, which conducted a survey — commissioned by infant formula manufacturer Perrigo — of 2,000 British adults.1

Not only did 82% of the adults surveyed have a minor health condition, but 59% said they were in “significant” pain or discomfort. Common conditions among those surveyed included back pain, headaches and seasonal allergies.

The study casts light on the day-to-day realities for thousands of people, whose quality of life is suffering due to long-term poor health. For more than one-quarter of those surveyed, their health complaints have been ongoing for several years, while 8% said their health conditions have been present for more than a decade. The implications to daily life are immense. Among those surveyed who have health issues:2

  • 46% have trouble sleeping

  • 28% developed mental health conditions

  • 18% can’t work

The survey also revealed that many people (57%) are suffering in silence, trying to cope with their health conditions on their own because their doctor “doesn’t seem interested” (28%). More than half of respondents also said they hadn’t considered stopping in to a drugstore for help. Perhaps hinting at the root of the problem, 56% of the adults surveyed said that they weren’t the best at self-care, and 43% said taking care of themselves wasn’t a priority.3

Unfortunately, without attention paid to the foundational cause of these health complaints, those affected are likely to receive disjointed, sporadic care and fall into the trap of polypharmacy, or the use of multiple medications.

What goes along with a laundry list of health complaints? Typically, a laundry list of medications. A 2017 survey of nearly 2,000 U.S. adults by Consumer Reports found that more than half of U.S. adults regularly take prescription medications, and the average adult takes four.4

The rate of prescribing has been skyrocketing as well, even outpacing the rate of population increase in the U.S. The Consumer Reports survey found that the total number of prescriptions filled by Americans (including children) increased by 85% from 1997 to 2016 — but the total U.S. population increased by only 21% during that time.

If you visit a doctor in the conventional medicine system, the fact is that you’re likely to be prescribed a medication. “About three-quarters of all visits to a physician end with a drug prescription,” according to a report in the journal Health Affairs.5 The U.S. FDA put the number at 64%.6

Either one is shocking, as is the fact that the average American adult takes four prescription drugs, and 75% of Americans take at least one over-the-counter drug regularly as well.7 As the FDA notes, “ADRs [adverse drug reactions] increase exponentially with four or more mediations.”8

The most common drugs prescribed give clues about the most common health complaints. In 2018, researchers with Larkin University’s College of Pharmacy compiled the top 200 prescribed drugs, along with their reported adverse reactions and black box warnings.9 I’ll focus on the top 20 here, which include:10

  1. Lisinopril, an ACE inhibitor used to treat high blood pressure and heart failure.

  2. Levothyroxine (Synthroid), a thyroid medication used to treat hypothyroidism.

  3. Atorvastatin (Lipitor), a statin to treat high cholesterol.

  4. Metformin (Glucophage), an antidiabetic drug used to treat Type 2 diabetes.

  5. Simvastatin (Zocor), a statin to treat high cholesterol.

  6. Omeprazole (Zegerid), a proton-pump inhibitor used to treat heartburn, stomach ulcers and gastroesophageal reflux disease (GERD).

  7. Amlodipine besylate (Norvasc), a calcium channel blocker to treat high blood pressure and chest pain (angina).

  8. Metoprolol (Toprol XL), a beta blocker used to treat high blood pressure, chest pain and heart failure.

  9. Acetaminophen/hydrocodone (Tylenol/Vicodin), a combination opioid analgesic used to relieve pain.

  10. Albuterol (ProAir HFA), a bronchodilator used to treat asthma, bronchitis, emphysema and other lung diseases.

  11. Hydrochlorothiazide (Microzide), a diuretic used to treat high blood pressure and fluid retention (edema).

  12. Losartan (Cozaar), an antihypertensive drug used to treat high blood pressure.

  13. Gabapentin (Neurontin), an anticonvulsant used to treat seizures, as well as pain and anxiety (an off-label use).

  14. Sertraline (Zoloft), a selective serotonin reuptake inhibitor (SSRI) used to treat depression, obsessive-compulsive disorder (OCD), posttraumatic stress disorder (PTSD), panic disorder and other mental health conditions.

  15. Furosemide (Lasix), a diuretic used to treat fluid retention.

  16. Acetaminophen (Tylenol), an analgesic used for pain relief.

  17. Atenolol (Tenormin), a beta blocker used to treat high blood pressure and chest pain.

  18. Pravastatin (Pravachol), a statin used to treat high cholesterol.

  19. Amoxicillin, a penicillin antibiotic used to treat infections.

  20. Fluoxetine (Prozac), an SSRI used to treat depression, OCD and other mental health conditions.

A range of adverse drug reactions were reported from the top 200 drugs, with the most common affecting the cardiovascular, gastrointestinal, respiratory, endocrine and immunological systems, among others. Common adverse reactions include the following — you’ll notice some of the reactions are the same as some of the symptoms the drugs are intended to treat:11

  • Chest pain

  • Edema

  • Thrombosis

  • Headache

  • Anxiety

  • Depression

  • Abdominal pain

  • Alopecia

  • Upper respiratory infections

  • Allergic rhinitis

  • Viral infections

  • Fungal infections

  • Tremor

  • Joint swelling

  • Anemia

  • Renal insufficiency

  • Urinary tract infection

  • Impaired vision

  • Tinnitus

  • Hemorrhage

  • Allergic conjunctivitis

If you suffer from multiple health conditions, your health is at risk not only from the illnesses but also from the multiple drugs prescribed to treat them. Adverse effects from polypharmacy are common and may drive patients to seek ever-more drugs to treat the side effects caused by their unsafe drug regimen. It’s a vicious cycle, one that’s perpetuated by a broken health care system that revolves around pharmaceutical-driven, fragmented care.

When medications are prescribed in excess, including to treat the side effects of other drugs, the patient’s health suffers. “The use of numerous medications may result in medication-related problems such as inappropriate indications, therapeutic duplication, adverse effects, drug interactions, unnecessary medications, poor adherence, and a strain on health care resources,” according to a featured article in The Journal for Nurse Practitioners.12

It also noted that polypharmacy is a preventable risk factor for hospital admission in older adults, due to adverse drug events. In BMC Geriatrics, adverse outcomes including mortality, falls, adverse drug reactions, increased length of hospital stay and hospital readmission are listed, and the risk of harm increases with the number of medications.13 According to the systematic review:14

“Harm can result due to a multitude of factors including drug-drug interactions and drug-disease interactions. Older patients are at even greater risk of adverse effects due to decreased renal and hepatic function, lower lean body mass, reduced hearing, vision, cognition and mobility.”

People over the age of 65 may be most at risk of polypharmacy’s adverse effects. While 89% of people aged 65 and older take at least one prescription medication, 54% take four or more.15

Data from Merck similarly found that nearly 80% of older adults regularly take at least two prescription drugs while 36% regularly use five or more different drugs — and this doesn’t include over-the-counter medications.16 Adding to the risks, Merck stated, “Most drugs used by older people for chronic disorders are taken for years.”17

While those over 65 tend to be the most medicated since they’re more likely to have one or more chronic conditions,18 even children are prescribed multiple, powerful drugs. In 2014, the Citizens Commission on Human Rights, a mental health watchdog group, highlighted data showing that in 2013:19

  • 274,000 babies aged 1 and younger were given psychiatric drugs. Of these, 249,699 were on antianxiety meds like Xanax, 26,406 were on antidepressants such as Prozac or Paxil, 1,422 were on ADHD drugs such as Ritalin and Adderall, and 654 were on antipsychotics such as Risperdal and Zyprexa

  • In the toddler category (2- to 3-year-olds), 318,997 were on antianxiety drugs, 46,102 were on antidepressants, 10,000 were prescribed ADHD drugs and 3,760 were on antipsychotics

  • Among children aged 5 and younger, 1,080,168 were on psychiatric drugs

The situation isn’t much better for teens. According to mail-order pharmacy Express Scripts, prescriptions for antidepressants for teenagers increased 38% from 2015 to 2019, while such prescriptions for adults rose 12% during that time.20 Note that this was prior to the pandemic, during which social isolation and other fears may have pushed some children with mental health issues “over the edge.”21

In 2021, more than one year into the pandemic, 1 in every 12 children under age 18 was on medication for ADD/ADHD, autism/ASD or difficulties with emotions, concentration or behavior, according to Psychology Today.22

“This includes 1.2% of preschoolers and 12.9% of 12- to 17-year-olds (1 in 8),” the magazine said, adding that even children as young as 2 “were being forced to take powerful antipsychotic drugs,” mostly in conjunction with one or more other psychiatric drugs for “the particularly vague diagnosis of ‘pervasive developmental disorder.’”

Being prescribed multiple psychotropic drugs to treat anxiety, depression or ADHD is incredibly common among youth. As noted in a study published in the journal Pediatrics in 2020, not only is the use of ADHD medication increasing but so is psychotherapeutic polypharmacy.23

From 2006 to 2015, prescriptions for ADHD medications among patients aged 2 to 24 years increased from 4.8% to 8.4%, while the percentage of those who were prescribed a drug for ADHD as well as at least one other medication rose from 26% to 40.7%.24

Most often, stimulants and α-2 agonists were prescribed together to treat ADHD, while the most common psychotropic agents prescribed in addition were selective serotonin reuptake inhibitors (SSRIs) and second-generation antipsychotics (SGAs).

“Surprisingly,” the researchers noted, “SGAs were coprescribed with ADHD medications most frequently at visits in the youngest patients (2-5 years of age)” — possibly in an attempt to treat sleep difficulties.25

Many chronic health conditions and mental health problems can be remedied with healthy lifestyle changes. One powerful step to protect your health is to eliminate or drastically reduce linoleic acid in your diet. Linoleic acid is the primary fat found in polyunsaturated fatty acids (PUFAs), including vegetable/seed oils. When oxidized, it degenerates into compounds that are carcinogenic, thrombogenic, mutagenic and genotoxic.26

Linoleic acid is found in virtually every processed food, including restaurant foods, sauces and salad dressings, so to eliminate it you’ll need to eliminate most processed foods and restaurant foods from your diet.

Time restricted eating (TRE) is another powerful intervention. It mimics the eating habits of our ancestors and restores your body to a more natural state that allows a whole host of metabolic benefits to occur.27

TRE involves limiting your eating window to six to eight hours per day instead of the more than 12-hour window most people use. Research shows, for instance, that TRE promotes insulin sensitivity and improves blood sugar management by increasing insulin-mediated glucose uptake rates,28 which is important for resolving Type 2 diabetes along with other metabolic health conditions.

Ideally, you’ll want to stop eating for several hours before bedtime, then start your eating window in mid- to late morning after you wake up. Remember, while it’s important to get back to the basics of eating whole foods, getting high-quality sleep, exercising and being active throughout your day and relieving stress, with each toxic exposure you remove from your life, the better health you’ll enjoy.

So along with adding in healthy elements, make a point to remove those that may be harming you, including toxic personal care and cleaning products, electromagnetic fields and unnecessary medications. When you address your health this way, on a holistic level, you can stay well and avoid polypharmacy at every life stage.

Subscribe to Mercola Newsletter

Disclaimer: The entire contents of this website are based upon the opinions of Dr. Mercola, unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked.

The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Mercola and his community. Dr. Mercola encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. The subscription fee being requested is for access to the articles and information posted on this site, and is not being paid for any individual medical advice.

If you are pregnant, nursing, taking medication, or have a medical condition, consult your health care professional before using products based on this content.

Executive Order Advances Biotech-Transhumanist Agenda

  • September 12, 2022, President Biden signed the “Executive Order on Advancing Biotechnology and Biomanufacturing Innovation for a Sustainable, Safe and Secure American Bioeconomy”

  • Specified in that order is the development of genetic engineering technologies and techniques “to be able to write circuitry for cells and predictably program biology in the same way in which we write software and program computers,” as well as genetic technologies to “unlock the power of biological data” using “computing tools and artificial intelligence”

  • This executive order establishes a fast-tracked pipeline of mRNA shots and other gene therapies that will further the transhumanist agenda to create augmented humans and bring us into a post-human world

  • Drug makers have clearly expected this free-for-all as they have loads of mRNA candidates in their pipelines. September 14, 2022, Pfizer initiated a Phase 3 study that will test a quadrivalent mRNA-based flu shot on 25,000 American adults

  • Moderna began its Phase 3 mRNA flu jab trial in early June 2022. Ultimately, Moderna wants to create an annual mRNA shot that covers all of the top 10 viruses that result in hospitalizations each year

Mercola Market on Amazon

Advertisement

September 12, 2022, President Biden signed the “Executive Order on Advancing Biotechnology and Biomanufacturing Innovation for a Sustainable, Safe and Secure American Bioeconomy.”1

Specified in that order is the development of genetic engineering technologies and techniques “to be able to write circuitry for cells and predictably program biology in the same way in which we write software and program computers,” as well as genetic technologies to “unlock the power of biological data” using “computing tools and artificial intelligence.”

Additionally, “obstacles for commercialization” will be reduced “so that innovative technologies and products can reach markets faster.” What we have here is, in a nutshell, the creation of a fast-tracked mRNA pipeline.

When, in June 2022, the U.S. Food and Drug Administration quietly implemented a “Future Framework” scheme2 to deliver reformulated COVID boosters without additional testing, I predicted that this “no testing required” formula would spread beyond COVID shots. And, according to this executive order, that’s exactly what’s about to happen.

In early September 2022, the FDA also put out medically false and misleading COVID booster campaign messages that prove we’ve officially entered the era of transhumanism:

“It’s time to install that update! #UpdateYourAntibodies with a new #COVID19 booster.”3 “Don’t be shocked! You can now #RechargeYourImmunity with an updated #COVID19 booster.”4

Historically, gene therapies have had to jump through extra hoops, which is why so few exist on the market. As of 2021, there were 20 gene therapies commercially available.5 The world’s first gene therapy trial didn’t begin until 1990, so this is still a very new field.

The entire gene therapy field actually collapsed overnight in 1999, when a teenage trial participant died from side effects. An FDA investigation concluded research had moved too fast and that safety “had not been put first.”6 Progress, thanks to increased caution, slowed from there on.

Such caution is now being thrown to the wind, and it’s not difficult to predict there will be disastrous ramifications. Millions will die from poorly tested gene therapies and, eventually, medical research and allopathic medicine will both cease to exist, as survivors vow to have nothing to do with that murderous cabal ever again.

The only way they might be able to keep going is if they are in control of people’s brain function and/or able to force drugs under threat of death, or worse — neither of which is impossible at this point, shockingly enough. In the meantime, we’re looking at a cornucopia of mRNA shots coming our way.

Not surprisingly, mRNA flu shots are in the works.7 While we probably won’t see mRNA flu shots during the 2022/2023 winter season, there’s every reason to expect they’ll be rolled out next year.

September 14, 2022, Pfizer initiated a Phase 3 study, which will test a quadrivalent mRNA-based flu shot on 25,000 American adults.8 Pfizer is also exploring mRNA technology that uses self-amplifying RNA (saRNA), for potential use in the future.9

Moderna began its Phase 3 mRNA flu jab trial in early June 2022.10 It’s also working on mRNA shots for respiratory syncytial virus (RSV) and cytomegalovirus (CMV), which is in the herpes family, as well as a SARS-CoV-2-influenza combination shot. Ultimately, Moderna wants to create an annual mRNA shot that covers all of the top 10 viruses that result in hospitalizations each year.11

Its current flu jab candidate, mRNA-1010, encodes for the hemagglutinin (HA) glycoproteins of four different influenza strains, including influenza A/H1N1, A/H3N2, influenza B/Yamagata and B/Victoria. According to Moderna:12

“HA is a major influenza surface glycoprotein that is considered an important target to generate broad protection against influenza and is the primary target of currently available influenza vaccines.”

Over the past three years, I’ve written several articles exploring the transhumanist agenda, which all these mRNA shots and genetic technologies are part and parcel of. Basically, the goal of the transhumanist movement is to transcend biology through technology, and to meld human biology with technology and artificial intelligence.

In September 2020, I posted a video with Dr. Carrie Madej (above), in which she suggested we were standing at the crossroads of transhumanism, thanks to the fast approaching release of mRNA COVID-19 shots.

“One reason why it’s important to know whether synthetic RNA creates permanent changes in the genome is because synthetic genes are patented. If they cause permanent changes, humans will contain patented genes, and that brings up very serious questions, seeing how patents have owners, and owners have patent rights.”

Since these shots are designed to manipulate your biology, they have the potential to also alter the biology of the entire human race. Nearly two years later, we still don’t know the extent to which they might be doing that, yet more fast-tracked and untested gene therapies are on the way.

One reason why it’s important to know for certain whether synthetic RNA ends up creating permanent changes in the genome is because synthetic genes are patented. If they cause permanent changes, humans will contain patented genes, and that brings up very serious questions, seeing how patents have owners, and owners have patent rights.

The hydrogel used to preserve the mRNA can also contain nanobots to create a bioelectric interface capable of connecting to a smartphone or other interface. Novel technologies that measure biological data, such as blood sugar, are based on this. Such technologies will, of course, have immediate ramifications for our privacy.

Who will collect and have access to all this data? Who will be responsible for protecting it? How will it be used? Also, if your cellphone can receive information from your body, what information can your body receive from it, or other sources? Could transmissions affect your mood? Your behavior? Your physical function? Your thoughts or memories?

So far, it doesn’t appear as though the COVID shots have these kinds of capabilities built in, but we do know for a fact that militaries around the world are exploring and working toward such capabilities. In fact, it’s an arms race in its own right.

In his September 14, 2022, Substack article,13 “Human Cyborgs Are Just the Beginning,” Dr. Robert Malone reviewed several of those plans. Certain report titles alone tell the story, such as the U.S. Department of Defense (DOD) Biotechnologies for Health and Human Performance Council’s report,14 “Cyborg Soldier 2050: Human/Machine Fusion and the Implications for the Future of the DOD.” It doesn’t leave a whole lot to the imagination, does it? According to the assessment abstract:

“The primary objective of this effort was to forecast and evaluate the military implications of machines that are physically integrated with the human body to augment and enhance human performance over the next 30 years.

This report summarizes this assessment and findings; identifies four potential military-use cases for new technologies in this area; and assesses their impact upon the DOD organizational structure, warfighter doctrine and tactics, and interoperability with U.S. allies and civil society.”

Human augmentation technologies deemed technically feasible by 2050 at the latest include ocular enhancements to improve sight and situational awareness, optogenetic bodysuit to restore or improve muscular strength and control, auditory enhancements, and neural enhancement of the brain for two-way data transfers and brain-to-brain communication.

In “The Plan to Turn You Into a Genetically Edited Cyborg,” I covered another shockingly dystopian report by the U.K. Ministry of Defense and the German Bundeswehr Office for Defense Planning, published in May 2021.

That report, “Human Augmentation — The Dawn of a New Paradigm, a Strategic Implications Project,”15 reviews the scientific goals of the U.K. and German defense ministries, and they basically mirror that of the U.S. DOD. On page 12 of the report, the concept of the human body as a platform is described, and how various parts of the human platform can be augmented. For example:

  • Physical performance such as strength, dexterity, speed and endurance can be enhanced, as well as physical senses. One example given is gene editing for enhanced sight 

  • Psychological performance such as cognition, emotion and motivation can be influenced to activate and direct desired behavior. Examples of cognitive augmentation include improving memory, attention, alertness, creativity, understanding, decision-making, intelligence and vigilance

  • Social performance — “The ability to perceive oneself as part of a group and the readiness to act as part of the team” — can be influenced. Communication skills, collaboration and trust are also included here

They list several different ways to influence the physical, psychological and social performance of the “human platform,” including genetics (germ line and somatic modification), synthetic biology, invasive (internal) and noninvasive (external) brain interfaces, passive and powered exoskeletons, drugs and nano technology, neurostimulation, augmented reality technologies such as external holograms or glasses with built-in artificial intelligence, and sensory augmentation technologies such as external sensors or implants.

As noted in this report, “Human augmentation has the potential to … change the meaning of what it means to be a human.” This is precisely what Klaus Schwab, founder and executive chairman of the World Economic Forum (WEF), has stated is the goal of The Fourth Industrial Revolution.16

WEF has been at the center of global affairs for more than 40 years, and if you take the time to dive into WEF’s Fourth Industrial Revolution material, you realize that it’s all about transhumanism. It’s about the merger of man and machine.

This is a dystopian future that WEF and its global allies are actively trying to implement, whether humanity at large agrees with it or not. Importantly, the “Human Augmentation” report readily admits that human augmentation can “directly enhance behavior.”

And, if you think these reports are just brain fodder for geeks in uniforms, think again. The U.K. Defense and Security Accelerator (DASA) is currently, right now, accepting proposals for human augmentation technologies such as those listed above.17 Grants of 70,000 euros ($74,000), will be given to proposals that can provide proof of concept.

Both the DOD’s “Cyborg Soldier” report and the British/German “Human Augmentation” reports discuss the fact that human augmentation will inevitably widen already existing disparities, inequalities and inequities, and therefore, “efforts should be undertaken to reverse negative cultural narratives of enhancement technologies.”18

In other words, don’t let people come to the conclusion that human cyborgs are a bad idea, because at worst that might prevent their development, and at best, it’ll pitch regular people against the augmented elite, making their efforts to rule the plebs more difficult.

As noted by Malone, “Once again, we are being played before we even know what the playing field looks like.”19

Disturbingly, considering how nontransparent governments have been so far, it’s not inconceivable that technologies capable of influencing thoughts and behaviors would be used on populations without informing anyone, which makes the list of potential risks one takes with each new mRNA injection even longer than it already is.

But we don’t need to be genetically reengineered or have nanobots introduced into our brains to be at risk of outside manipulation. That’s already happening through noninvasive means.

In a November 2019 interview with CNN,20 history professor Yuval Noah Harari, a Klaus Schwab disciple, stated that humans are already “hackable,” meaning the technology exists by which a company or government can know you better than you know yourself, and this knowledge can be used for both good and ill.

According to Harari, the available capabilities already go far beyond Orwell’s “1984” authoritarian vision, and it’s only going to become more powerful from here.

He predicted that algorithms will increasingly be used to make decisions that historically have been made by humans, either yourself or someone else, including whether or not you’ll be hired for a particular job, whether you’ll be granted a loan, what scholastic curriculum you will follow and even whom you will marry.

To learn more about the larger issues of transhumanism and the race to merge man with machine and artificial intelligence, check out the Truthstream Media video below.

For example, there are even ongoing attempts to upload the human mind into the cloud, ultimately creating a form of “digital hive mind” where everyone communicates via “Wi-Fi telepathy.” This, despite the fact we still do not fully understand what “the mind” actually is, or where it’s located.

I don’t know what it will take to prevent the dystopian post-human world envisioned by Schwab and his technocratic minions, but I suspect education would be a cornerstone of such an endeavor. In order for there to be a resistance, enough people need to be aware of what the plan is, and where we’re actually being led with all these novel therapies and inventions.

In the shorter term, it’s crucial to realize that the fast-tracking of “genetic engineering technologies and techniques to be able to write circuitry for cells and predictably program biology in the same way in which we write software and program computers” means they’re going to cut corners. Loads of them.

Testing is basically going to be done on the population at large, just as they’ve done with the COVID jabs. The results of such experimentation are relatively predictable. People will be seriously injured and many will die. So, think long and hard before you agree to take any of these forthcoming gene therapies.

Access this content 48 hours faster by subscribing to the FREE Mercola Health Newsletter today.

Subscribe to Mercola Newsletter

Disclaimer: The entire contents of this website are based upon the opinions of Dr. Mercola, unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked.

The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Mercola and his community. Dr. Mercola encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. The subscription fee being requested is for access to the articles and information posted on this site, and is not being paid for any individual medical advice.

If you are pregnant, nursing, taking medication, or have a medical condition, consult your health care professional before using products based on this content.

Why Coffee Affects Metabolism

  • Researchers found the caffeine in one standard cup of coffee stimulated brown fat activity, burning more energy and potentially improving insulin sensitivity. These activities may help improve weight management

  • Daily coffee drinkers also enjoy greater metabolism of fatty acids and a downregulation of the endocannabinoid system, which regulates cognition, immunity, sleep and appetite, having the opposite effect in the body than the ingestion of cannabis

  • Your body has white fat and brown fat cells; the white cells may be programmed to brown cells when the programming is not naturally suppressed by a special protein. Conversion of white to brown fat is known as “beige” or “brite” fat

  • The location of fat is important, since subcutaneous fat just under the skin is not as dangerous as visceral fat found deep in your abdomen around your organs. You may increase the activity of the brown fat you already have through exercise, exposure to cold and sleeping in a cool environment

Mercola Market on Amazon

Advertisement

Many people struggle with obesity and being overweight. According to the CDC, the prevalence of both conditions was measured nationally in 2015-2016, finding 71.6% of the U.S. population were either overweight or obese. By 2022 that number had escalated to 74%. Although some corporations, like Coca-Cola propose you may out-exercise a poor diet, research has found it is a combination of a healthy diet and exercise that has the greatest benefit.

In mid-2015 The New York Times reported on the activities of Global Energy Balance Network, a nonprofit organization funded by Coca-Cola to promote the argument that exercise is more important than diet. The organization disbanded by the end of the year.

In 2017, weight loss and weight management was worth $66 billion each year according to a market research firm Marketdata, LLC. In their press release they reported that the number of active dieters had fallen by 10% since 2015.

The market — which can include diet pills, shakes and supplements, medical weight loss clinics, frozen entrees and online services — declined during the pandemic to a record low of $58 billion, but quickly rose to $72.6 billion in 2021.

There are several factors contributing to your ability to lose weight, including getting enough quality sleep each night, supporting a healthy gut microbiome and choosing to eat more whole food and less processed food. A recent study published in Scientific Reports has demonstrated coffee may affect your metabolism and mobilize metabolically active brown fat.

Brown adipose tissue (BAT) may generate heat (thermogenesis) and burn glucose and fats through a mitochondrial reaction mediated by mitochondrial uncoupling protein 1 (UCP1). Energy balance prevents the development of obesity, and while physical activity may dissipate some energy, the body also uses a system of thermogenesis, or the production of heat through the burning of energy.

Upregulation of UCP1 may reduce the potential for obesity and improve insulin sensitivity as it is one of the systems of thermogenesis in brown fat. In the Scientific Reports study, researchers looked at the effect of caffeine on BAT both in the test tube and in humans.

They wrote that past studies demonstrated the activation of BAT through nutrients or cold exposure. Caffeine demonstrated an upregulation of UCP1 in obese mice but the extent that it directly affected BAT in humans was not known. The researchers first used cells from mice and human bone marrow stem cells cultured in a test tube and then introduced caffeine.

Their analysis was performed using several tests, including mitochondrial staining, transmission electron microscopy and gene expression analysis. Next, nine healthy human volunteers with a mean body mass index of 23, within normal range, were engaged to participate. They either drank a caffeinated beverage or water and then remained sitting for 30 minutes.

The researchers found treatment of the cell cultures with caffeine increased the expression of UCP1. They also analyzed and compared the thermal imaging done 30 minutes after drinking the beverages against those done before.

The images showed an increased temperature of BAT in the subclavicular area in adults after drinking coffee. This reflected an increase in heat production in BAT not demonstrated after drinking water.

The Scientific Reports researchers said this is the first study to demonstrate caffeine’s stimulation on UCP1 in vitro that could be projected to the ingestion of caffeine by humans through a standard sized cup of coffee. Michael Symonds, Ph.D., from the school of medicine at the University of Nottingham, co-directed the study. As reported in a press release from the university, he commented:

“From our previous work, we knew that brown fat is mainly located in the neck region, so we were able to image someone straight after they had a drink to see if the brown fat got hotter. The results were positive and we now need to ascertain that caffeine as one of the ingredients in the coffee is acting as the stimulus or if there’s another component helping with the activation of brown fat.”

The researchers believe this suggested that caffeine in a standard cup of coffee could increase the metabolic rate and enhance BAT function. They theorize this activity has the potential to contribute to weight loss. They wrote:

“In conclusion, these results provide new complementary in vitro and in vivo evidence that caffeine (and a coffee beverage) can promote BAT function at doses compatible with human use.”

New discoveries about coffee and the impact it has on health are reported frequently. Some reports state that caffeine helps you live longer, while others associate caffeine with increasing your potential risk to danger. It can be difficult to know what to believe.

In a study published by Northwestern Medicine, scientists discovered coffee changed significantly more metabolites in the body than had been known. After eating or drinking, your body produces metabolites, or chemicals. A higher number of affected metabolites may explain, in part, the number of effects coffee has on the body.

The researchers gathered 47 habitual coffee drinkers and ask them to stop drinking coffee for one month. In the following month the participants drank four cups of coffee each day and in the last month they drank eight cups of coffee each day. During the study, the researchers collected samples of their blood, evaluating for the number and type of metabolites.

They found that the levels of 115 metabolites were altered by drinking coffee, 82 of which were known to affect 33 biological pathways. They also discovered three novel links to coffee including steroid metabolites, fatty acid metabolism and the effect it had on the endocannabinoid system.

Your body normally has cannabinoid receptors in the neurological system. The researchers found the neurotransmitters related to this system were reduced after drinking four to eight cups of coffee each day. The effect is opposite of what would be expected when cannabis is ingested.

The researchers point out the body’s endocannabinoid system regulates cognition, immunity, sleep, appetite and energy functions to name a few. Additionally, they found the metabolites related to the androsteroid system, suggesting to the researchers coffee may help eliminate steroids from the body.

This may help in cancers significantly affected by steroid levels. Lead author Marilyn Cornelis, Ph.D., assistant professor of preventive medicine, commented:

“These are entirely new pathways by which coffee might affect health. Now we want to delve deeper and study how these changes affect the body. The increased coffee consumption over the two-month span of the trial may have created enough stress to trigger a decrease in metabolites in this system. It could be our bodies’ adaptation to try to get stress levels back to equilibrium.”

Regarding the association among coffee, weight loss and a reduced risk of Type 2 diabetes, she said:

“This is often thought to be due to caffeine’s ability to boost fat metabolism or the glucose-regulating effects of polyphenols (plant-derived chemicals). Our new findings linking coffee to endocannabinoids offer alternative explanations worthy of further study.”

Three different types of fat perform different functions in your body. Researchers in the featured study were interested in the effect caffeine would have on activating BAT, and thus increase thermogenesis and energy metabolism. Symonds commented:

“Brown fat works in a different way to other fat in your body and produces heat by burning sugar and fat, often in response to cold. Increasing its activity improves blood sugar control as well as improving blood lipid levels and the extra calories burnt help with weight loss. However, until now, no one has found an acceptable way to stimulate its activity in humans.

This is the first study in humans to show that something like a cup of coffee can have a direct effect on our brown fat functions. The potential implications of our results are pretty big, as obesity is a major health concern for society and we also have a growing diabetes epidemic and brown fat could potentially be part of the solution in tackling them.”

The most common type of fat cells are white adipocytes, where excess energy is stored, increasing the risk of obesity. Overloading these cells leads to related conditions, such as Type 2 diabetes and cardiovascular disease. On the other side of the spectrum are brown adipocytes, which are thermogenically active and more prevalent in children than adults.

Researchers have discovered white fat cells may be programmed to turn brown, but this programming is suppressed by the FLCN protein. The function to suppress brown fat programming is performed in cooperation with another pathway, which is active during cell processes, including tumor formation, insulin resistance and fat cell growth.

That particular pathway, called mTOR, is activated by amino acids and insulin, as well as growth factors, which in turn help suppress brown fat programming. The conversion of white fat to BAT cells is known as “brite” or “beige” fat cells.

The body’s sympathetic nervous system is capable of doing this on a small scale but since white fat cells are connected to other organ systems, on a large scale within the body it is not possible. Scientists are experimenting with conversion of white fat outside the body to beige fat and then reintroducing to help fight obesity.

Where fat is located on your body makes a difference to your health. White fat performs two important functions: It stores excess calories and releases hormones that control metabolism. Fat may be stored directly under the skin, called subcutaneous fat, or deep in the abdomen around your organs, called visceral fat.

Subcutaneous fat is often found on the thighs and buttocks and does not usually cause as many problems as visceral. According to Harvard Health, 90% of body fat in most individuals is subcutaneous, which might be described as the fat you can pinch. It accumulates in the lower body, creating a pear shape.

The remaining 10% is intra-abdominal or visceral fat, beneath the abdominal wall and surrounding your organs. This type of fat is strongly associated with metabolic syndrome and insulin resistance. In a study from the University of Illinois, researchers found a regulatory molecule produced a bodily response leading to higher amounts of visceral fat with increased caloric intake.

One way the mTOR pathway is stimulated is through excessive protein intake. This stimulation helps suppress white fat to BAT programming. There are additional ways of activating your brown fat to burn more energy and convert some of your white fat to beige, also increasing thermogenesis, without drugs or surgery. Here are five strategies you may consider:

  • Exercise — In a study from The Ohio State University Wexner Medical Center, researchers found one reason exercise may boost metabolism is through increasing levels of a lipokine molecule that had been linked to cold temperatures in the past.

    • The researchers found the function of brown fat during exercise was to tell the muscle to use more fatty acids as fuel. They confirmed their results in an animal study during which they found lipokines after the mice exercised, but once BAT was removed from the mice there was no evidence of exercise-induced increase.

  • Cold — Several studies have demonstrated that exposure to cold temperatures increases glucose burning in brown fat and upregulates UCP1 proteins. It also increases BAT activation, reduces fat and changes mitochondria in skeletal muscle and BAT. Daily exposure increases the volume of BAT and the oxidative capacity.

  • Sleep — One method studied to expose participants to a cool environment was to reduce the ambient temperature during sleep. Researchers engaged five men over four months. The participants did their regular activities during the day and then returned to their rooms each evening.

    • The temperature in the room was set to 75 degrees Fahrenheit (F) during the first month, 66 F in the following two months, and 81 F in the final month. After one month of exposure to mild cold temperatures the researchers measured a 42% increase in BAT volume and 10% rise in metabolic activity in the participants.

Subscribe to Mercola Newsletter

Disclaimer: The entire contents of this website are based upon the opinions of Dr. Mercola, unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked.

The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Mercola and his community. Dr. Mercola encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. The subscription fee being requested is for access to the articles and information posted on this site, and is not being paid for any individual medical advice.

If you are pregnant, nursing, taking medication, or have a medical condition, consult your health care professional before using products based on this content.

US Health in Crisis

  • In 2017 to 2018, only 6.8% of U.S. adults had optimal cardiometabolic health, which means more than 93% of U.S. adults are metabolically unfit

  • In my interview on the “Good Morning CHD” daily news show, I discuss simple ways to radically improve your health if you fall into that metabolically unfit category

  • The basics to restoring metabolic health are to use time-restricted eating, avoid processed foods and linoleic acid, and get daily sun exposure

  • Time-restricted eating involves limiting your eating window to a set number of hours during the day; I recommend getting down to a six- to eight-hour eating window with stopping all eating at least three hours before bed

  • I also share three essential compounds that should be in your emergency medicine kit — methylene blue, melatonin and nebulized hydrogen peroxide

Mercola Market on Amazon

Advertisement

A landmark study came out in July 2022, showing that as of 2018, only 6.8% of U.S. adults had optimal cardiometabolic health.1 What this means is that more than 93% of U.S. adults are metabolically unfit, and the actual percentage is probably over 95%, as we don’t have the 2022 data yet — but do know that cardiometabolic health in the U.S. is “poor and worsening.”2

This health crisis in the U.S. formed the foundation of my recent discussion with Polly Tommey, director of programming for Children’s Health Defense (CHD) TV, as part of their “Good Morning CHD” daily news show.3 Before I got into how to radically improve your health if you fall into that metabolically unfit category, I shared two essential compounds that I believe everyone should keep in their medicine cabinet.

Methylene blue is the parent molecule for hydroxychloroquine and chloroquine, off-patent drugs commonly used to treat not only malaria but also COVID-19. Methylene blue is actually the oldest drug in the world. It was discovered in 1876 and used as a textile dye for blue jeans, but it has many important medicinal benefits.

It is a highly effective agent against urinary tract infections (UTIs), as it is excreted by your kidneys into your bladder where it reaches very high concentrations and becomes a potent oxidant stress that kills virtually any pathogen in the bladder — without disrupting the microbiome the way antibiotics do.

Methylene blue is also the only known antidote for cyanide poisoning, but the reason why you absolutely should have it in your medicine cabinet has to do with cardiovascular disease, including heart attacks and strokes.

When you have a heart attack or most strokes, it is due to a blood clot that results in loss of blood flow to the heart or brain. If the amount of tissue is significant it will result in death. Reestablishment of blood flow is essential to salvage these tissues. However, reestablishing blood flow, or reperfusion, itself paradoxically causes further damage, threatening function and viability of the heart or brain.

Reperfusion injury is also called ischemia-reperfusion injury or reoxygenation injury. The absence of oxygen and nutrients from blood during the ischemic period creates a condition in which the reestablishment of circulation results in inflammation and oxidative damage through causing oxidative stress rather than restoring normal function.

If you take methylene blue, you can significantly decrease the tissue damage that occurs. However, dosage is important, as you only need a small amount and you don’t want to overdose on it. I recommend using a microspoon for measuring the proper amount, and I discussed dosing suggestions in my interview with Francisco Gonzalez-Lima, Ph.D., who is an expert on methylene blue.

Low doses, 0.5 milligram (mg) to 1 mg per kilo of bodyweight, are recommended for nonacute, longer-term treatments, including the prevention and treatment of dementia, post-stroke and other brain injuries, cognitive enhancement, and the general optimization of health if you’re already healthy.

The second compound that I recommend keeping on hand is melatonin — in a 10 mg sublingual dose. It’s a powerful antioxidant and will limit the reperfusion injury if taken right away after a heart attack or stroke. It’s important that the methylene blue is also administered quickly, ideally within minutes, of the heart attack or stroke.

The longer you wait after the injury the less likely it will provide benefit, which is why it’s essential to keep these items on hand, in your emergency medicine kit.4

There’s industrial grade methylene blue, which you don’t want to get because the manufacturing process typically results in heavy metal contamination. There’s also pharmaceutical grade, but it’s difficult to find or expensive in a powder form. Then there is chemical, or sometimes referred to as lab-grade which, depending on the company, can have very low heavy metals.

You can purchase methylene blue that’s already dissolved in water, but that’s not as good as buying the powder itself and putting it into water. Remember, you’ll need a microspoon for precise measurements.

Time-restricted eating (TRE) involves limiting your eating window to a set number of hours during the day. I recommend getting down to at least a six- to eight-hour eating window — and ensuring that you stop eating at least three hours before bed.

Most people reading this can benefit from embracing TRE, with the exceptions being if you’re underweight or pregnant. When you’re metabolically unfit, your body primarily relies on glucose, or sugar, as fuel, instead of using fat as a primary fuel.

Even though the fat is there in abundance, your body doesn’t have the metabolic capacity to access it. For most people, surplus fuel stored in your body is stored in the form of fat. However, no one has more than about two days’ worth of glucose in the form of glycogen, stored in their tissues in their liver and muscles. This is why, when you first start fasting, and you’re unable to access your fat stores, you’ll quickly exhaust your glycogen stores and can experience low blood sugar.

Your body has the ability to make glucose in your liver (gluconeogenesis), but that process takes a while to ramp up and, as a result, most people get relatively hypoglycemic when they first start fasting. You may experience dizziness and fatigue as a result, which are signs that you’re not metabolically flexible. If you were, your body would have more than enough capacity to produce all the fuel you need to keep your brain happy and healthy.5

In the interview, I also pointed out that if you’re obese, you can typically safely go on three-, five- or even seven-day water fasts. Many experts are predicting upcoming food shortages and economic collapse come fall, and I wanted to reassure people that most who fall in this category could probably not eat for months, some people for up to a year, if they’re grossly overweight, and they would be significantly healthier for it.6

Again, fasting isn’t recommended for people who are underweight, pregnant or breastfeeding. You also need to use caution if you’re taking certain medications, such as those for blood pressure or blood sugar.7 Interestingly, when you’re metabolically inflexible and unable to use fat for fuel, your body generates a molecule called acetyl-CoA when it’s breaking down fats — and that happens to be one of the cofactors for your body making melatonin.

So when you’re metabolically inflexible, your body produces far less melatonin — a potent anticancer agent — in the mitochondria where you need it, because that’s where almost all the damage that causes cancer is caused — due to oxidative stress from the process of generating energy within the mitochondria.8

TRE is so powerful that rat studies suggest changing the eating window leads to beneficial effects on health,9 regardless of what’s eaten during that time. That being said, your results are going to be best if you’re eating healthy food. With respect to food, the most important change to make is cutting out industrially processed seed oils, which are misleadingly labeled as vegetable oils.

Examples of seed oils high in omega-6 PUFAs include soybean, cottonseed, sunflower, rapeseed (canola), corn and safflower.10 Omega-6 is considered to be proinflammatory because of the most common variety, linoleic acid (LA), which will radically increase oxidative stress and cause mitochondrial dysfunction.11

In order to avoid LA, you’ll need to avoid eating processed foods and focus on real food instead. If you eat real food and use TRE, your body will become healthier because it’s designed to do this if you provide it with what it needs. If you don’t follow these ancestral guidelines to good health, it predisposes you to disease.

Now, if you eat real food, use TRE and get about one hour of daily sun exposure, that’s going to reduce your risk of 90% to 95% of chronic diseases.12 If you want to get more advanced, you can add in sauna usage, which helps you eliminate toxins and activates beneficial heat shock proteins that refold your proteins to prevent diseases like dementia.

The wavelengths from a near infrared sauna, which heats your body the most effectively, actually penetrate your skin about 3 to 4 inches and get into your mitochondria, causing your mitochondria to make melatonin. About 95% of the melatonin in your body is made in the mitochondria, and near infrared saunas are the only type that have this added benefit of also increasing melatonin.13

As you focus on eating real food and restricting your eating window, it is important to avoid making the mistake of going no-carb or low-carb, as your body needs carbohydrates. While you may initially improve if you cut out carbs, over time it will raise your cortisol levels and can actually lead to insulin resistance and hormonal imbalance.

Foods like watermelon, apples and blueberries can help you add nutrient-rich carbohydrates to your diet. Many people also wonder about coffee, which can be consumed outside of your eating window because it has almost no calories. The coffee should be organic, black and mycotoxin-free.

As for alcohol, it will break your fast if you consume it outside of your eating window. Small amounts may be OK to consume inside of your eating window, but it may impair your sleep if you consume it too close to bedtime, and be aware that wine is a source of the toxic chemical glyphosate. Ideally, I believe alcohol is better off avoided.

Finally, one additional compound that should be added to your emergency medical kit is hydrogen peroxide and a nebulizer. Like methylene blue and melatonin, nebulized hydrogen peroxide is something you’ll want to have on hand for immediate use when you need it. I use nebulized hydrogen peroxide most mornings, but if you start feeling sick, you can use it every few hours, or more, to ward off illness.

If you get these basics down — time-restricted eating, avoiding processed foods and LA, and getting daily sun exposure — you can significantly reduce your risk of becoming chronically ill, and even join the 6.8% of Americans who have been able to maintain good cardiometabolic health.

Access this content 48 hours faster by subscribing to the FREE Mercola Health Newsletter today.

Subscribe to Mercola Newsletter

Disclaimer: The entire contents of this website are based upon the opinions of Dr. Mercola, unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked.

The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Mercola and his community. Dr. Mercola encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. The subscription fee being requested is for access to the articles and information posted on this site, and is not being paid for any individual medical advice.

If you are pregnant, nursing, taking medication, or have a medical condition, consult your health care professional before using products based on this content.

Black Pepper: So Much More Than a Spice

  • Pepper comes in several colors, but the most common are black and white. Both come from the same plant and the color difference is related to when the fruit is picked and how it’s processed

  • The major bioactive compound in pepper is piperine, which is responsible for many diverse health benefits. Peppercorns are high in antioxidant properties, which may play a role in cancer, liver disease, atherosclerosis and the aging process

  • Piperine increases the absorption and bioavailability of other nutrients, and has cardioprotective, neuroprotective and hepatoprotective properties

  • Black pepper improves digestion, aids weight management, promotes skin and hair health, and aids in blood sugar control. Lab studies show the antiviral properties of black pepper are effective against Ebola, Dengue and SARS-CoV-2

  • For best results, grind whole peppercorns just before using them to retain the flavor and potency of the health benefits

Mercola Market on Amazon

Advertisement

Pepper is so common that it’s easy to take for granted. Not only does this savory and spicy seasoning add a powerful kick to your meals, but it also adds an impressive boost to your health regimen. Black pepper (Piper Nigrum L.) was originally grown in the Western Ghats, a stretch of land along the west coast of India.1

The plants can be easily grown at home in a pot and by choosing when you harvest the fruit, you can get black, white, green and red peppercorns from the same plant.2 The global market is expanding and expected to grow from $3.9 billion in 2020 to $5.99 billion by 2028.3

According to a market study by Fior Markets,4 the growth is driven in part by using black pepper as a natural preservative in food products and the addition to the cosmetic industry where it’s used for its antibacterial and antioxidant properties.5 However, supply has not met demand primarily because of crop losses that resulted from climate change and sudden rains.

Black pepper has been prized since ancient times, once known as the “king of spices” and “black gold.”6 Pepper was so highly profitable that traders set their own prices, which led to the spice becoming a luxury item. Even today, the Dutch term “peperduur,” which means as expensive as pepper, is used to describe anything extremely expensive.7

Pepper has played a role in the traditional medicines of India and China,8 and is a key component in Ayurvedic medicine. It is believed that pepper was first brought from India to China for medicinal purposes and went on to be used in traditional medicine in Greece and Rome.

There are two main pepper choices — black or white pepper. While black pepper is a mainstay in many households, white pepper is equally appealing, if not quite as widely used, at least in the U.S. Color is the most obvious distinction between the two.

Some recipes use white pepper instead of black because the appearance of the final dish is lighter. However, beyond the appearance, there are other important differences, beginning with how they are processed. As for which is better, that’s a personal choice since both have great value.

As described in the short video above, white and black peppercorns are made from the fruit of the piper nigrum plant. Black peppercorns are made using unripe berries, which are then cooked and dried. The drying process gives the black peppercorn a dark appearance, wrinkled texture and pungent flavor.

White peppercorns are picked fully ripe when the fruit is red. The fruit is soaked, the outer skin is removed, and the seed is dried, which results in white peppercorns. There are subtle differences in flavor, as the black peppercorns are more pungent, and the white has an earthy flavor.

Both types of peppercorns contain similar amounts of piperine, which is the substance responsible for the pungency, heat and health benefits. Overall, white and black peppercorns contain between 6.3% and 7% of the alkaloid piperine,9 which has been shown to be beneficial for arthritis, even in small doses.10

  1. Antioxidant Properties — Black pepper contains powerful antioxidants and black pepper essential oil is also rich in flavonoids, proanthocyanidins and phenolics, which also have strong antioxidant activity.11 Piperine, which is the main active ingredient, is an anti-inflammatory and helps protect against lipid peroxidation,12 which may play a role in chronic diseases like cancer, liver disease, atherosclerosis and the aging process.

    A comparative analysis of the antioxidant activity between black pepper and white pepper revealed that black pepper extracts were most effective.13 There are two commonly used pepper extracts — essential oil and oleoresins.14

    Pepper essential oil is commercially extracted from the berries using steam distillation, while pepper oleoresin is an extract using solvents and contains a blend of essential oil, compounds like piperine and resinous matter. An analysis of the antioxidant activity of essential oil and oleoresins shows both extracts have strong antioxidant activity.15

  2. Maximizes the Health Benefits of Curcumin — Black pepper has a unique ability to interact with other nutrients and increase their absorption.16 For example, when EGCG from green tea is administered with piperine, the absorption of EGCG increases.17

    When piperine is administered with curcumin, it can raise the bioavailability of curcumin by up to 2,000%.18 19 The health benefits of curcumin include pain reduction,20 improving cognitive function and mood in older adults21 and a beneficial effect on irritable bowel syndrome symptoms.22

  3. Cardioprotective Properties — Cardiovascular diseases continue to be among the leading causes of death.23 A systematic review24 in December 2020 found black pepper and piperine have protective effects on cardiovascular diseases.

    Key findings included regulation of lipid metabolism, inflammation and oxidation status, all of which affect heart health. Piperine specifically targeted processes associated with atherosclerosis. Other beneficial effects included attenuating high blood pressure, heart injury and fibrosis. Piperine could prevent lipid peroxidation and prevent inflammatory cells from adhering to the endothelial monolayer and has an antithrombosis effect.

    Additionally, one 2022 review25 summarized the cardioprotective benefits of black pepper against the chemotherapeutic drug-induced cardiotoxicity that occurs with the administration of chemotherapeutic drugs in those with cancer.

  4. Immunomodulatory and Anticancer Activities — Piperine is packed with flavonoids, carotenes, vitamins and antioxidants that have shown a beneficial effect in the prevention of cancer.26 Lab studies have found that black pepper has an immunomodulatory effect, and it augments the production of nitric oxide while enhancing the cytotoxic activity of natural killer cells.27

    These findings suggest that black pepper plays a role in anti-tumor activities and may potentially be used to help regulate inflammatory responses and prevent carcinogenesis. Piperine also has antimutagenic and cancer-preventive effects in lab studies and animal research.28 29 30

  5. Neuroprotective Properties — Animal studies have found that piperine may be beneficial for cognitive function.31 Black pepper extract significantly improved the memory in rats with Alzheimer’s-like disease,32 33 reduced damage from cerebral ischemic injury34 and had a protective effect on Parkinson-like disease.35

  6. Aids in Digestion — Black pepper is believed to improve digestion by stimulating the production of hydrochloric acid in the stomach.36 A lack of hydrochloric acid can lead to heartburn or indigestion. Piperine also stimulates digestive enzymes in the pancreas which enhances digestion and reduces food transit time.37 Black pepper is also a potential prebiotic as it modulates fecal bacteria communities.38

  7. Weight Management — Piperine has displayed several pharmacological effects, including anti-obesity properties in lab and animal models.39 Lab models have demonstrated that black pepper extract and piperine could strongly inhibit adipogenic activity and piperine plays a role in regulating genes associated with fat metabolism.40

    When a nutritional supplement containing black pepper was tested, it burned as many calories as would a 20-minute walk.41 A small study with 16 healthy individuals showed a black pepper-based beverage could modulate the appetite by lowering their feelings of hunger and increasing satiety.42

  8. Promotes Healthy Skin — According to Stylecraze,43 black pepper can be used on your skin and hair. They recommend mixing a teaspoon of black pepper with equal amounts of honey or turmeric. Water can be added to make a smoother consistency and then apply it as a mask to your face twice a day.

    A teaspoon of crushed pepper and a bowl of curd can be used to help treat dandruff. Leave it on the scalp for about 30 minutes and wash it off with water without shampoo. Combining a teaspoon of lemon and ground black pepper seeds can help revitalize the hair and leave it shiny, according to Stylecraze. Leave it on for 10 to 15 minutes and rinse it off with cold water.

    Adding powdered black pepper with equal amounts of honey may help strengthen the hair roots. Clinical trials have also tested black pepper in the treatment of vitiligo, a disease in which the skin loses its pigment.

    Black pepper has been used in ayurvedic medicine for vitiligo44 and a paper45 published in 2018 demonstrated that combining topical piperine with narrow-band ultraviolet B light had better results than just the ultraviolet light alone in treating vitiligo.

  9. Antimicrobial Properties — Plants have been used in traditional medicine for centuries, and black pepper is known for its anti-inflammatory, antiviral and antipyretic properties.46 One lab study in 2020 demonstrated that an aqueous seed extract of black pepper had significant antiviral, antibacterial and antifungal activity.47

    A molecular docking study demonstrated that piperine may be effective against Ebola and Dengue, both RNA viruses that are endemic in tropical areas.48 As you might expect, black pepper was also tested against SARS-CoV-2, the virus that causes COVID-19. The study suggested that piperine was a potential inhibitor at the RNA binding site and could be a candidate to inhibit viral proliferation.49

  10. Hepatoprotective Properties — The pharmacological actions of piperine include liver protection50 against damage induced by tertiary butyl hydroperoxide and the chemical carbon tetrachloride by reducing lipid peroxidation. Black pepper extract can also stimulate liver regeneration51 and one animal study52 showed black pepper essential oil improved liver health after chemical injury.

    The prevalence of liver fibrosis in the general population can reach up to 25.7%53 and can lead to significant liver disease. One animal study54 demonstrated that supplementation with piperine in rats fed a high-carbohydrate, high-fat diet could reduce liver fibrosis, improve cardiac and hepatic inflammatory cell infiltration and improve liver function.

  11. Blood Sugar Control — Up to 11.3% of the U.S. population have diabetes and 38% have prediabetes.55 The consequences of diabetes are significant, leading to heart disease, stroke and kidney disease. Adding black pepper routinely to your diet may help improve blood sugar metabolism.56

    One eight-week study57 of 86 overweight individuals found those who consumed a combination of piperine and other bioactive food ingredients had a significant decrease in insulin resistance. This suggested that the ingredients, which included EGCG, capsaicin and L-Carnitine, “might be useful for the treatment of obesity-related inflammatory metabolic dysfunctions.”58

For the best results, choose to use whole peppercorns and grind them fresh as you need them. Dried whole peppercorns can stay fresh for three to four years when they’re stored in a cool, dark place away from direct sunlight or heat.59

However, once peppercorns are ground, they gradually lose some flavor and potency. Additionally, purchasing ground pepper increases the risk that the product is adulterated with something other than black pepper. Peppercorns are versatile, so you can grind them to a coarseness you enjoy or crush them to pepper coat your beef before cooking.

Access this content 48 hours faster by subscribing to the FREE Mercola Health Newsletter today.

Subscribe to Mercola Newsletter

Disclaimer: The entire contents of this website are based upon the opinions of Dr. Mercola, unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked.

The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Mercola and his community. Dr. Mercola encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. The subscription fee being requested is for access to the articles and information posted on this site, and is not being paid for any individual medical advice.

If you are pregnant, nursing, taking medication, or have a medical condition, consult your health care professional before using products based on this content.