Woman Shares Her Incredible Paranormal Experience She Had At Brown Mountain, North Carolina

What are “paranormal experiences”? I don’t really understand the term anymore, it used to describe events and experiences that were out of the ordinary, it implies that these events are not ‘normal.’ It’s almost 2019, and more and more people are starting to become aware of the fact that “paranormal” experiences are actually quite normal, quite common, and well documented throughout history. We have evidence in the form of video footage, pictures, and actual physical evidence from several different supposed events. Not only that, ‘paranormal’ discoveries have been the subject of rigorous investigations by governments and researchers around the world. The ‘Stargate’ program in the United States, for example, was one that studied these experiences in order to use them for intelligence purposes, and they worked. Here’s a great example from the Central Intelligence Agency’s electronic reading room about an individual who was able to move solid objects through solid barriers, by simply using his mind. You can read more about that, in-depth, here.

We live in a strange world, one in which we don’t quite understand and for the most part, we still shy away from and label findings in the paranormal world as different, not real, pseudoscience or the stuff of imagination. Humanity has a long history of not accepting certain phenomena based on the fact that it may shatter a few of our long-held and ingrained belief systems, wherever they may come from. We also have a long history of phenomena not being acknowledged to protect certain interests. The UFO phenomenon is a great example, where suppressed, although kept secret for multiple reasons, is kept due to the new energy and propulsion systems that could come from it.

The story that’s the topic of this article is no different, it will definitely shatter your belief systems if you’re not into this stuff, but if you are, you probably won’t be surprised, especially given the fact that the experience took place at Brown Mountain, North Carolina, which is a place full of stories similar to this one.

Brown Mountain is known for what’s now become known as the “Brown Mountain Lights.” They represent a series of strange lights in the form of multiple colours that are often spotted near or on Brown Mountain. The lights can be seen from multiple spots, there was also help from the city of Morganton (North Carolina) via a building overlook on North Carolina highway 181. They are fairly well known…

Below is one of many pictures floating around the internet from supposed experiences. Below this one is an official ‘verifiable’ one.

A website based in North Carolina who takes interest in this lore explains it quite well:

Brown Mountain is a low ridge in Burke County that, during dry, crisp evenings in the autumn, is host to a genuine and baffling mystery. When conditions are right, mysterious glowing orbs can be seen to rise up off the mountain, hover and wobble about fifteen feet up in the air, and then disappear. There’s no denying that the lights are real. They have been observed by countless witnesses and photographed on many occasions. But what they are is still unknown.

The Brown Mountain Lights have been observed for centuries, and multiple legends have arisen around the phenomenon. The Cherokee were aware of the lights, and according to some accounts claimed that the lights were the souls of Cherokee women searching for their men who had died in a great battle between the Cherokee and the Catawba that took place on Brown Mountain. Another legend says that the lights are the the ghostly echoes of lights that appeared during a search for a murdered woman in the 19th century.

Below is a video that was taken from Scientists at Appalachian State University, who caught the phenomenon on camera as well. Researchers captured these glowing lights simultaneously by two time-lapse digital video cameras near the mountain, which is located just north of Morganton. The cameras are operated by Daniel Caton and his colleague Lee Hawkins, of the physics and astronomy department at Appalachian State.

The lore of Brown Mountain is filled with so many stories, real stories, from real people, that it’s surprising how little well known it still is.  As far as the lights go, there are many different explanations that have come forth. Everything from extraterrestrial to interdimensional, to ghosts and more.  Skeptics have suggested that they are headlights from automobiles from the valley below, but the lights have been observed for more than one hundred years. If you look up pictures, videos and stories about the phenomenon, you’ll see how ridiculous the headlight explanation is. Some have suggested that the lights could be a naturally-occurring electrical discharge caused by the geological fault line below the mountain.

One Experience (out of many) On Brown Mountain

This story was shared last year by a YouTuber who has a channel called “Insane Disappearances.” This man has done a lot of research into missing persons inside of National Parks. Himself and other researchers in the field describe many similar strange findings that all of these experiences have in common. He managed to conduct an interview with a person who chose to remain anonymous, due to fear. After her experience (she was also with two others), she explains how she was harassed by police as well as park authorities, asking to confiscate the pictures and the video footage she took. She kept receiving calls on a regular basis from authorities asking her about her experience, and on multiple occasions, authorities emphasized how it was a long day, she was dehydrated and simply hallucinating.

I don’t usually share stories that comprise simply of witness testimony, but after listening to this woman’s story, seeing the pictures and watching her videos of her experience, it really resonated with me and really came across in an extreme genuine fashion. The way she was telling it just makes me believe this is a genuine person who actually had a strange experience. What was also interesting to note was her urgency in getting the pictures as well as the videos up online for public access before they could be taken away from her.

The story starts off with the woman hiking with her friends. All of a sudden, her friends instantly disappeared from the trail, but everything else remained the same. She started to look for them and began to experience strange things, like the path shifting, noticing water streams in an area of the mountain where she was sure there were no streams. She heard strange noises, and captured shots of a strange orange glowing orb that appeared to follow her. She also claims that sometimes, this apparition took on the form of a humanoid looking being. Her friends also had unique experiences as she did, and when they eventually came out of the situation, they compared notes, pictures, footage and stories…

As the day progressed, I kept feeling like, almost like the forest was kind of re-arranging itself around me. I swear that I turned directly behind me but the trail would be different… I also kept hearing things and weird whooshing of air… I kept seeing what looked like these bright orange colours that were, I don’t know if they were following me…

Here’s a message from the YouTube video description:

If you have an open mind this is the place to be. Join me, become intrigued as I case-read the four hundred and eleven baffling unsolved cases about hundreds of random people from clusters all over the globe who mysteriously vanish without a trace and are either never seen again or found hundreds of miles away from their last known location; deceased under weird circumstances. Todays episode is a validations interview that will answer all your questions about what happens to people who venture into our national parks to never be seen or heard from again. But with evident proof like this everyone’s perception will always be different because of their own level of experiences. So with that being said I believe her because the people that weren’t there to see what she saw are not going to believe her at first because those people are looking for extensive detailed analyzation, picking apart the evidence in her footage, lie detector tests, etc. at the end of the day she had an experience; an amazing yet creepy experience that answered every single question ever asked

It might be time to plan a trip to Brown Mountain ;). You can find all of the pictures, footage and interviews on his channel if you want to dive into this particular mystery a little further!

The Takeaway

There is a simple takeaway message that goes with this article and it’s the fact that it’s okay to entertain an idea without accepting it. It’s also important to acknowledge phenomena that are not ‘officially’ acknowledged within the mainstream as ‘real,’ simply because these realities have tremendous implications. The story of the experiencer described in this article, although I have no doubts at all, might not be real. That being said, strange stories, occurrences, and footage coming out of this area confirm without a doubt that the phenomenon of the Brown Mountain lights are indeed real, as far as what they are, remains to be unknown. A common theme that comes out of these stories also seems to correlate with some type of extraterrestrial activity. There have been ‘scary’ stories and wonderful stories of contact that also surround this mountain.

Can You Guess How Much CO2 is Mankind Responsible For?

Global warming and climate change alarmists harp on about “dangerously high” manmade CO2 output levels. So how much are they? The answer will shock you.

by Makia Freeman, guest writer,

You would think manmade CO2 output levels must be sky-high, given all the relentless guilt-tripping propaganda we are fed about how humanity is the cause of global warming. The agenda to push AGW (Anthropogenic Global Warming) or manmade global warming started around the 1980s and has been gaining momentum for decades, fooling many people along the way.

Read Entire Article »

x22Report.com 10-3-18… “The Beginning Indicator That Signals The End Of The Fed”

Listened to this yesterday and the point he made about DJT “not showing his taxes, by refusing to do so” signaling the end of the Fed was a prime point from this one.


Published on Oct 3, 2018
ADP rebounds as Aug is revised. The plan is moving forward, use the manipulation that had been used in the past to make the economy look incredible. US services economy is bouncing all over the place and a lot doesn’t make sense, hello manipulation. The retail apocalypse is picking up speed, more stores are filing for bankruptcy. US households load up on stocks, this is a recipe for a disaster. NYT uses taxes to get at Trump and his family. Trump signaled the end of the Fed and the deep state by not showing his taxes, by refusing to do so. In the end this will all be reversed.

Additional P.S. For the Generals, the Popes, and the Monarchs:

By Anna Von Reitz

Our formerly Delegated Powers returned to us by Operation of Law the moment the original Federal level of the Federal Government was rendered incompetent in 1860, but we were not told this by our Trustees. 

The Delegated Powers merely “assumed” by the Scottish Interloper doing business as “The United States of America, Inc.” returned to us again in 1907, when that entity declared bankruptcy.  Again, we were not informed by our Trustees. 

The Delegated Powers merely “assumed” by the Roman Catholic Church Delaware Corporation doing business as the “United States of America” Inc. returned to us again in 1933, when that entity declared bankruptcy, but again, we were not informed by our Trustees.

So, as should be apparent, these Trustees aren’t worth the powder to blow them to Hell and back.

When the bankruptcy of the “United States of America” Inc. settled in November of 1999, our claim in behalf of ourselves and The United States of America [Unincorporated] had already cured for over a year.  Again, our Trustees never said a word.

We were astonished and confused: who are these people pretending to be our Trustees, who don’t respond to us—or for us or for our benefit? 

Thus began a long and arduous journey.

Our Delegated Powers have been commandeered for over 150 years by Foreign Interests that had absolutely no right whatsoever to do what they have done in this country.  Our identity has been stolen along with our assets by these Trustees operating in Gross Breach of Trust and violation of Commercial Contract.

All Parties including the Principals have been given extensive Due Process and Due Notice culminating in a Final Civil Judgment entered and published worldwide in April 2014. 

So when the UNITED STATES, Inc. went bankrupt in 2015, we re-issued our Sovereign Letters Patent, and reclaimed the STATES OF STATES and the States of States and rolled them into the Federal State (Misnamed “Land”) Trusts.  When the Territorial “Government” similarly declared bankruptcy in 2017, we said– very clearly — enough is enough. 

All three levels of the so-called Federal Government were at that point incompetent.  The actual Federal Government intended and ordained by our ancestors has been held in a phony “abeyance” since 1860.  The Municipal Government was liquidated.  The Territorial Government bankrupt.

By Operation of Law all Delegated Powers returned to us, to the Federation of States that delegated the “Powers” in the first place — The United States of America [Unincorporated] and the American States and People.  As this is an Operation of Law, no court action is necessary and no controversy is present.  It simply is, and we are here, present and accounted for –officially– since 1998. 

Our purported Trustees have continued to ignore us to the extent possible, so we issued a formal Acknowledgement, Acceptance, and Re-Conveyance on June 6, 2018.

We also re-conveyed all the Federal State Trusts back to the ownership of the sovereign States where they remain protected on the land jurisdiction of The United States of America [Unincorporated] and each of the States. This is all a matter of public record, firmly established by UCC notices and liens and land recording district records in Alaska and Illinois and various other locations.

We have reminded the Queen and the Popes of their duties with respect to us and our States and our People, as well as reminding the Government of Westminster of their Treaty obligations.

We have also reminded everyone of the fact that members of the Bar Associations are prohibited from holding any public office or position of trust related to our government and that has been the case since 1819.  Thus no action undertaken by any Bar Attorney, including their votes in the Territorial United State Congress or Municipal United States Congress, can ever be presumed to apply to us or our assets in any way, shape, or form.

This is no threat to anyone nor is it any provocation of war.  It is simply a matter of actual ownership interest and Law, which we have exercised. Contrary to the expectations of many, our assets are not “abandoned”, not “unclaimed” and they are no longer subject to contrived commercial claims by Secondary Creditors, nor any administration by Bar Attorneys subject to the Crown.

We consider what has gone on here to be a crime, both a recognizable international crime and a domestic crime.  We consider that the perpetrators have aimed at the overthrow of not only our government but all national governments worldwide.

The United States of America [Unincorporated] is the actual government owed to the American States and People and it is our established and lawful right and obligation to function in both international trade and commerce effective July 17, 2014.

We have done so and we have standing to do so.

All Trade Names of living people issued on or arising from the land and soil of the American States and all derivatives thereof are Public Trusts of The United States of America [Unincorporated] and they always have been. They are all assets of the land and soil, not engaged in any form of interstate commerce.

Review that fact in view of the false commercial claims and unlawful conversions of the Franklin Delano Roosevelt Administration.  Also review that fact in view of the false commercial claims made upon American Negroes and other people of color by the Scottish Government dba “The United States of America” Incorporated.

Every dog has its day and you have all had yours. What remains is a necessary and profound —and lasting— correction on all your parts.

See this article and over 1200 others on Anna’s website here: www.annavonreitz.com

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Stealing Title to Babies

By Anna Von Reitz

Yes, I said it. That is, objectively, what they have been doing for at least six generations, if you count —-and I do– their outrageous fraud and Breach of Trust during and after the so-called “Civil War”, when they “took title” to every supposedly freed former Plantation Slave in America as property belonging to their commercial corporations.  

And then, they just continued with more of the same rot, expanding and institutionalizing and mechanizing and compartmentalizing and applying the same scheme to everyone, until —- according to them —- damn near everyone is a “voluntary” slave who has donated everything including their own Name to these criminal commercial corporations.

They have been purposefully creating “public trusts” and operating those public trusts “in our names” for the express purpose of misrepresenting us, stealing our identities, siphoning off our assets, and racking up debt against our assets. 

This is no different than what any Credit Card Hacker or Identity Thief does, except that these organizations have been masquerading as governments and abusing their position of trust as government service providers.

They have “taken title” to over 300 million American babies.  Think about that. Think of how hideous and unlawful the entire concept is.  These corporations claim to own you. Literally.  And they have hired troupes of actors wearing black robes and mercenaries wearing your own uniforms, waving your own flags, using your own money and assets to enforce these slave-owner claims against you. 

And who are “they” but criminals caught in the act?  Slave traders. Kidnappers. Pirates. Vermin. Outlaws.  Truly despicable criminals in nice suits, having dinner at the finest restaurants on your ticket, jet-setting around the world pretending to “represent” you in one respect or another, all blatant as pigs can be.

More than 30 Trillion Dollars has been siphoned off and embezzled out of this country during the Obama Administration and more untold trillions of counterfeit “US Dollars” were printed off-shore and dumped into other economies worldwide — and it was all state sponsored counterfeiting by “government agencies”.  They used official government printing presses and papers and inks and engraving plates to do it.  And they fully intended to leave the clueless American People responsible for paying for it.

Do we need any other reason to disband the CIA?

All of this was going on under whose noses? 

The DIA and the FBI and DHS and Homeland Security and the Armed Forces and the National Guard and State and Local Police Forces and the Department of Administration and the GAO and the US Mint and “Treasury”.   

Do we need any other reason to fire all of them and start over?

The problem–  from their standpoint–  is that we found out about all of this corruption and criminality as a result of historical and legal research spanning decades. 

As for the actual owners of this country, the American States and People, dba The United States of America [Unincorporated] and The United States [Unincorporated]  we object to any supposition that the debts and criminality of “the” United States of America, Inc., and “the” United States, Inc.,  has anything to do with us, our States, our People, or our assets. 

British and European and yes, some American Traitors, set this Bunko Scheme up to secretively profit from American assets and to revive their old disgraced Colonial System— allowing the Monarchs and Robber Barons to enslave and steal from others, and in our case, set us up to take the blame for them, too.   

They have done a good job of stealing us blind and using us as gun fodder in their commercial mercenary “wars”, but the jig is up.  

We are the Priority Creditors and Number One victims of these criminals, and we have proof in the public record going back before The American Revolution demonstrating that  “the” United States and “the” United States of America responsible for all this rottenness are corporate doppelgangers or “ringers” that simply infringed upon our Good Name and our Common Law copyrights as a means of purposefully promoting identity theft, credit fraud, bankruptcy fraud, press-ganging, inland piracy, unlawful conversion, and other international and confidence crimes going back generations.

We know who they are.  We know where they live.  We know how they profited themselves illegally and immorally and in flagrant disrespect of the Public Law.  We can cite Chapter and Verse and step-by-step demonstrate how this entire odious system worked.

And now, it is time for it to end.

The Titles must be returned to the “missing” owners, who were somehow easy for the tax collectors and Selective Service to find, and the entire abhorrent practice of corporations “taking title” to men and women must be consigned to the Rubbish Heap of History where all such practices belong. 

See this article and over 1200 others on Anna’s website here: www.annavonreitz.com

To support this work look for the PayPal button on this website.

For All the Generals, the Popes, and the Monarchs:

By Anna Von Reitz

This is all just business, gentlemen.

There is the “United States of America” Incorporated, which you will see referenced in The Definitive Treaty of Paris, 1783, which names King George III as “Arch-Treasurer” of that British commercial corporation.

And then, there is “The United States of America” [Unincorporated] which is, just coincidentally, the American Common Law copyrighted name of the Federation of our States operating in international trade and commerce as of September 9, 1776 — years before the Treaty of Paris hit the bricks.

So what is going on here?

It’s called “mirroring” — a deliberate effort to confuse one thing for another, by semantic deceit or other means, seeking to deceive the gullible among us for purposes of unjust enrichment via direct theft — as in identity theft — or via surreptitious theft of credit, both of which have gone on here. 
They have run up debts “in the name of” the United States of America and then left everyone to assume that those debts are debts owed by The United States of America.

This is not the first time they have done this fraud scheme pas de deux. The only difference is that we woke up and caught them at it. 
Now they are telling you that the “United States” and the “United States of America” are both bankrupt and they can’t make the payroll. But which “United States of America” are they talking about?

Well, get a clue. It’s not us. It’s not our Federation of States and most importantly, not our people on the hook for this. It wasn’t us on the hook last time they pulled this crappola in 1907 or 1933, either — but we were dunned for it. And we stupidly paid it, because it appeared to be addressed to us.

This time, it’s not going to go the way they would like it to go. They are going to pay their own debts and honor their obligations to this country, including the vast debt that they already owe us as a result of their earlier fraud. 
We realize that they can’t possibly pay it all back and that we will have to forgive vast amounts of debt, but at the end of the day, there is no doubt whatever that we are their Priority Creditors.

Which means that we are owed all the credit and money that they purloined from our States and that we have first dibs— not the Secondary Creditors. And not the “US Trustees” appointed as bankruptcy Trustees by those Secondary Creditors.

As for you, Generals, if you want to get paid, the process is simple enough. Go back to work for the actual States and People that you owe your allegiance to: The United States of America [Unincorporated]. It’s going to be a lot easier to put the screws to Rome, London, Edinburgh, and Hong Kong than it is to deal with 350 million outraged Americans, a billion Chinese and only God knows how many Russians.

See this article and over 1200 others on Anna’s website here: www.annavonreitz.com

To support this work look for the PayPal button on this website.

Genetically Modified Children (FREE VIEWING – LIMITED TIME)

Watch the FREE SCREENING of Genetically Modified Children Above (Available for a Limited Time)

Written By: Stephanie Seneff

There is a growing awareness that glyphosate is much more toxic than we have been led to believe, and I am confident that in time it will be banned worldwide, just like DDT


Glyphosate is the active ingredient in the pervasive herbicide Roundup. Together with several colleagues, I have published extensively on the dangers of glyphosate to human health and to the ecosystem. Most people believe that glyphosate is practically non-toxic to humans, in part because governments are claiming that this is so, and people want to believe that their government is trustworthy. But there is a growing awareness that glyphosate is much more toxic than we have been led to believe, and I am confident that in time it will be banned worldwide, just like DDT.

One way to find out whether glyphosate is toxic is to get to know the people who are in the front lines: those who are exposed, environmentally or occupationally, to heavy doses of glyphosate in their daily lives. A good choice might be people who live in a small village in northern Argentina that is surrounded by fields of tobacco that have been genetically engineered to resist it. This is what two investigative journalists set out to do, and their efforts have borne fruit in the form of an informative, engaging and disturbing documentary.

Several years ago, I discovered that a genetically-engineered glyphosate-resistant tobacco seed had been developed and patented [1]; however, it is very difficult to find out what percentage of the tobacco crops are actually grown from these engineered seeds. One anecdotal answer to this question comes from the recently released documentary, Genetically Modified Children, produced and directed by Juliette Igier and Stephanie Lebrun. This movie describes the severe health issues that afflict the children of agricultural workers who live surrounded by glyphosate-resistant tobacco crops produced for sale exclusively to the tobacco company, Philip Morris. The farmers who were interviewed readily admitted that Philip Morris would most likely reject their product if they did not use glyphosate to control weeds and Bayer’s insecticide Confidor to control insects.

The documentary reveals the severe physical deformities, mental disabilities and cancers the children of these tobacco farmers are experiencing, and it offers the rather audacious hypothesis that glyphosate is inducing genetic mutations in the children of these farmers. Could they be right?

In the remainder of this article, I will first describe some of the serious health issues of the children who live near the tobacco fields, as portrayed in the documentary. After a short section about correlations between glyphosate and various diseases, I will discuss, in the following three sections, both the evidence that glyphosate causes birth defects, infertility, developmental issues, DNA damage and cancer, and the plausible biological mechanisms that could explain a link. The next section is devoted to describing the evidence that glyphosate can get into proteins by mistake in place of the coding amino acid glycine, which I now believe is its main mechanism of insidious cumulative toxicity. The rest of the article focuses on two proteins in particular that could get disrupted through glyphosate substitution, and I will explain how this disruption can lead to a runaway phosphorylation cascade resulting in cancer. I will conclude with an urgent request that we change our agricultural methods towards renewable organic solutions, in order to protect future generations from harm.

Damaged Children

The documentary included accounts of several children who were clearly very sick with disorders connected to impaired development of the neural tube and/or rare genetic diseases, as well as an unusually high incidence of cancer. Two children in this small community were born with hydrocephalus, a condition in which cerebrospinal fluid accumulates in the brain, causing an unusually large head. In infants, it is associated with a bulging fontanelle (the soft spot), irritability, seizures, vomiting and sleepiness, as well as impaired memory development. It is often linked to a rare genetic defect, and about 80-90% of newborn infants with spina bifida develop hydrocephalus. Another child suffered from another disorder directly caused by impaired neural tube development, called myelomingocele. A myelomeningocele manifests as a protrusion of meningeal membranes through an opening in the spinal column, often in the lower back region, which appears as a sac enclosing the meninges, cerebrospinal fluid, and parts of the spinal cord and nerve roots. Another child was diagnosed with congenital microcephaly, along with epilepsy, delayed motor and mental development, and multiple muscular atrophy.

Yet another child suffered from lamellar ichthyosis, a rare genetic condition often caused by mutations in the gene for the protein keratinocyte transglutaminase, which results in excessive production of keratin, causing scaly, itchy skin, along with an increased risk to hypothermia and bacterial skin infection. Children with this condition have scaly skin all over their body, and are highly susceptible to toxic exposures on the skin that readily pass the defective barrier.

There was a high rate of miscarriages among the women of the community. The rate of childhood cancer in this small community was five times as high as the rate in the general population in Argentina. Leukemia and lymphoma were prevalent among the adults as well as the children. The alarming health issues in this community, particularly neural tube defects, were documented in an interview conducted with Professor Hugo Gomez Demaio, Head of Neurosurgery at the Pediatric Hospital of Posadas, Argentina [2].

Correlations between glyphosate and various diseases

Swanson et al. published a paper in 2014 showing over 20 graphs of strong correlations in the United States over time between glyphosate usage on core crops and various diseases and conditions. Several of these were specific cancers, including pancreatic cancer (p < 4.6E-7)[1]thyroid cancer (p < 7.6E-9), bladder cancer (p < 4.7E-9), liver cancer (p < 4.6E-8), kidney cancer (p < 2.0E-8) and myeloid leukemia (p < 1.5E-6) [3]. A follow-on paper from 2015 by Hoy et al. looked specifically at diseases of newborns and found highly significant correlations between the rise in diseases of the lymph system, among children (p < 0.00043) and adults (p < 0.00023), congenital heart defects among newborns (p < 9.2E-6), newborn lung disorders (p < 3.4E-5), and newborn genitourinary disorders (p < 2.4E-5) [4], among others. Exemplary plots for pancreatic cancer and genitourinary disorders are reproduced here as Figures 1 and 2.

Figure 1: Correlation between age-adjusted thyroid cancer incidence and glyphosate applications and percentage of US corn and soy crops that are genetically engineered. Reproduced from Swanson et al. 2014 [3]?.

The incidence rates for non-Hodgkin’s lymphoma, tumors of the brain and spinal cord, and liver and kidney tumors have all increased among children in the U.S. during the period from 2001 to 2014, in step with the rise in glyphosate usage on core crops [5].

Glyphosate and Spina Bifida

A myelomeningocele is the most severe form of spina bifida, which, more generally, is a defect in the maturation of the spinal column due to impaired neural tube closure at a critical time during early embryonic development. It is associated with problems in walking, problems with bladder and bowel control, and hydrocephalus. The causes of spina bifida are multifactorial, and include folate deficiency, excessive retinoic acid exposure, impaired methylation capacity, impaired transsulfation pathway, impaired glucose metabolism, and impaired nucleic acid repair systems.

Figure 2: Hospital discharge rates for newborn genitourinary disorders compared to glyphosate applications to wheat, corn and soy crops. See Hoy et al., 2015 [4] for details.

Every one of these impairments could be attributed to glyphosate, as explained in a paper I published together with colleagues linking glyphosate to anencephaly (child born with a missing cerebral cortex) [6]. Folate deficiency is probably the most well known causal factor in spina bifida, and this is what motivated the US government to require folate fortification of wheat-based products starting in 1998, just as the use of genetically engineered Roundup-Ready crops was ramping up. Glyphosate’s link to folate deficiency is easy to understand because folate is synthesized by the gut microbes for the host from products of the shikimate pathway [7]. Impaired bacterial supply of folate due to glyphosate’s interference with their shikimate pathway will lead to deficiencies in the human host. Glyphosate’s disruption of the shikimate pathway has been identified as its key mechanism of toxicity to weeds [8].

Methionine deficiency is another link to neural tube defects, because methionine supplies methyl groups that are necessary for proper development of the nervous system. Glyphosate has also been shown to deplete methionine in plants and to disrupt biological pathways in Escherichia coli (E. coli) that synthesize methionine from inorganic sulfur, as described in [6]. Methionine deficiency disrupts both the methylation pathways and the trans-sulfuration pathways. Glyphosate can also be predicted to disrupt the clearance of retinoic acid, which is metabolized through cytochrome P450 enzymes, which are inhibited by glyphosate. Details of how glyphosate disrupts these critical pathways as well as glucose metabolism and nucleic acid repair mechanisms are also discussed in the paper on anencephaly [6].

Glyphosate and the Reproductive System

Both human population studies and animal studies have shown multiple issues with the reproductive system in association with glyphosate exposure. Argentina uses 240,000 tons of glyphosate in its industrial agriculture program annually. Physicians in agricultural areas have noticed an increase in reproductive disorders in the communities they serve. A formal study published in 2018, based in the rural town of Monte Maíz, found that the rate of spontaneous abortion was three times as high as the national average, and the rate of congenital anomolies was doubled [9].

In a recent study on pregnant women in Indiana, more than 90% of them tested positive for urinary glyphosate, and higher glyphosate levels were statistically significantly associated with a shortened gestational period [10]. The US consumes more glyphosate than most other countries, and our rates of premature births have been rising in the past decade. We also have a higher rate of premature births than other Western nations [11].

An extraordinarily high rate of severe congenital malformations in piglets from a Danish farm inspired an investigation in which tissue samples from various organs of 38 deformed one-day old piglets were tested for glyphosate contamination. Glyphosate was found at levels as high as 80 micrograms/gram, with the lungs and heart showing the highest levels of contamination [12].

A new paper studying multigenerational effects of glyphosate in an animal model obtained a remarkable result that suggests that the germ cells of a fetus are especially susceptible to genetic mutation by glyphosate in utero [13]. An extraordinary feature of mammalian reproduction is that the female fetus develops its ovaries very early in gestation, long before major brain development takes place [14]. Toxic exposures to the ovaries prenatally can lead to polycystic ovary syndrome (PCOS) and premature ovarian failure (POF) [15]. More ominously, because the second generation germ cells are already present early in the gestation period, they could be subject to mutations induced by a mutagenic agent that has bridged the placental barrier.

In the experiment [13], pregnant rats were exposed to glyphosate starting at day 9 of gestation and extending beyond birth into the period when the pups were being nursed. These pups were allowed to mature and also give birth to a second generation. All three generations were evaluated for any evidence of harm by glyphosate. Two different levels of exposure were set (low and high), but both were below the daily limit set by the United States EPA.

While the mothers experienced no obvious damage from glyphosate, the second generation had a reduced litter size, suggesting impaired fertility, and the growth of their pups in utero was slow, resulting in low birth weight. However, the most remarkable result of the study was a high rate of rare mutations in the second generation pups. Three out of the 117 total second generation fetuses suffered from rare severe malformations (siamese twins and abnormally developed limbs), and these three were from three different mothers within the first generation. This suggests that exposure of germ cells in utero to glyphosate induces a high mutation rate, an idea that I will develop more fully later in this article.

Evidence that Glyphosate Causes DNA Damage and Cancer

An early step in the progression towards cancer and towards genetic mutations is DNA damage, often induced by oxidative stress — the attack on DNA molecules by oxidizing agents such as superoxide and peroxynitrite. A common technique in the research lab for assessing the potential of a given chemical as a carcinogen is to expose cells to the chemical and then examine them under a microscope looking for evidence of damage, such as achromatic lesions (gaps in the chromosomes that are visible through a microscope) and chromatid deletions (entirely missing parts of a chromosome). These are typically caused by double strand breaks in the DNA strand that makes up the chromosome [16]. Multiple repair mechanisms exist to try to restore the proper DNA sequence following a break, but these repair mechanisms can introduce a copy error that results in a DNA mutation.

Does glyphosate induce double strand breaks in DNA? Monsanto’s own 1983 unpublished report found over twice as many achromatic lesions and chromatid deletions in rat bone marrow cells exposed to glyphosate compared to controls [17]. Several independent studies have confirmed that glyphosate causes double strand breaks and also induces the oxidative stress that usually precedes DNA damage.

A paper from Colombia showed that people living in regions surrounded by glyphosate-sprayed crops due to coca and poppy eradication efforts had significantly higher counts of cellular defects linked to DNA damage compared to people living in an area where organic coffee was grown [18]. Similarly, a study based in northern Ecuador examined DNA damage through the well-established comet assay in white blood cell samples taken from people who had been exposed to glyphosate drift from across the border (from aerial spraying in Colombia). They found that the average comet length in the exposed group was 35.5 micrometers, compared to only 25.94 micrometers in the control group [19]. The comet assay is used to detect double-strand DNA breaks.

A paper published in 2010 examined the genotoxic effects to eels of acute exposure to Roundup at realistic dosages [20]. Comet assay demonstrated that Roundup induced DNA double-strand breaks as well as chromosomal abnormalities. This paper revealed a surprising result, in that several measures of oxidative stress proved negative, implying that the DNA damage was sometimes occurring through some other mechanism besides oxidative stress.

However, a study on tropical fish exposed to sublethal doses of Roundup found evidence of an increase in the synthesis of proteins associated with antioxidant defenses, suggesting that glyphosate, or at least its formulation, Roundup, does induce reactive oxygen species, and this was associated with evidence of DNA damage in red blood cells [21]. Glyphosate exposure to a species of freshwater fish at three sublethal test concentrations caused oxidative stress in the gills and blood, as assessed through increased lipid peroxidation and increased synthesis of antioxidant defense proteins, as well as DNA damage as assessed by comet assays [22]. Damage to the gills was worse than damage to the blood.

An important study published in 2018 and conducted in response to the World Health Organization’s International Agency for Research on Cancer (IARC) classification of glyphosate as a probable carcinogen showed an increased risk to both single and double DNA strand breaks as well as oxidation of DNA nucleotides in white blood cells exposed over a 24 hour period to glyphosate, its breakdown product AMPA, or its formulation Roundup. The formulation was found to be significantly more genotoxic than the isolated chemicals. They suggested that glyphosate and AMPA cause oxidative damage by increasing production of reactive oxygen species in the cell, and this in turn induces DNA breaks [23].

DNA hypomethylation is an initiating step in the conversion of a cell to a pluripotent state, giving it stem-cell like features that are also characteristic of cancerous tissues. A 2018 study conducted in Poland showed that glyphosate exposure at a relatively low dose (0.25 millimolar) induced significant modifications in the methylation pattern on the DNA of white blood cells [24]. Specifically, globally, DNA was hypomethylated in the presence of glyphosate, whereas the promoter region of TP53, a tumor suppressor gene, was hypermethylated. Such hypermethylation has the effect of suppressing expression of this gene; i.e., enhancing the likelihood of cancer.

Many women who have gone through breast cancer treatment are aware that breast cancer cells have estrogen receptors, and the tumor will grow under estrogenic influences. This fact is what led to the sharp curtailing of hormone replacement therapy once it became clear that it was associated with an alarming increase in risk to breast cancer. Estrogen-sensitive breast cancer cells have been found to respond to minute doses of glyphosate, measured in parts per trillion, by proliferating [25]. This strongly suggests that glyphosate is an estrogenic agent.

A proteomic approach to investigate alterations in protein expression in mouse skin following topical exposure to glyphosate revealed that many proteins were either upregulated or downregulated, and the modified expression pattern was consistent with carcinogenic potential [26]. Most striking was a nearly ten-fold upregulation in a protein called calgranulin B. Calgranulin B has been shown to promote cell proliferation, migration and invasion in squamous cervical cancer [27].

Glyphosate as a Glycine Analogue

Glyphosate is a deceptively simple molecule, and it is surprising that it is so potent as an herbicide, indiscriminately killing all plants except those that are engineered to be resistant. One very unique property of glyphosate is that it is an amino acid analogue of glycine. In fact, it is a complete glycine molecule, except that extra material (namely, a methyl phosphonyl group) has been attached to the nitrogen atom. Part of its toxicity has to do with its ability to mimic glycine at glycine receptor sites, stimulating calcium entry [28, 29], and another part has to do with interfering with reactions where glycine is a substrate [30]. However, a much more insidious potential mechanism of toxicity is the possibility that it substitutes by mistake for glycine, a coding amino acid, during protein synthesis. As a consequence of my intense interest in this question, I have studied extensively the essential roles of various glycine residues in a long list of biologically important proteins, acting as enzymes, receptors, transport proteins, structural proteins, etc. Remarkably, many of the diseases whose frequency is going up alarmingly over time in step with the alarming rise in glyphosate usage on core crops can be explained through disruption of specific glycine residues in specific proteins, as has been demonstrated thus far for gout [31], amyotrophic lateral sclerosis (ALS) [32], Mesoamerican nephropathy [33], anencephaly [6], Alzheimer’s disease, diabetes, and obesity [34], and neurological diseases such as autism and multiple sclerosis [35]. Glyphosate is the only pesticide used in agriculture whose usage rate has gone up dramatically over the past two decades, in step with the dramatic rise in a long list of debilitating diseases and conditions.

One of Monsanto’s own studies from 1989 virtually proved that this is happening. The study involved exposing blue-gill sunfish to radiolabelled glyphosate and then checking for radiolabel in tissue samples. They found a remarkable discrepancy between the amount of radiolabel and the amount of glyphosate detected through a standard assay. They were able to close the gap significantly, however, by subjecting the sample to proteolysis enzymes (proteinase K), and they suggested that a plausible interpretation of their finding was that glyphosate was getting incorporated into the protein [17]. Glyphosate assays fail to detect glyphosate when it is embedded in a peptide chain, whereas proteolysis separates the individual amino acids from the chain, freeing up the glyphosate and making it now visible to the assay.

Another huge piece of evidence comes from mutations in the enzyme in the shikimate pathway that glyphosate famously disrupts, called 5-enolpyruvylshikimate-3-phosphate (EPSP) synthase. EPSP synthase binds electrostatically to its substrate, phosphoenol pyruvate (PEP), couched within a carefully shaped pocket. A highly conserved glycine residue helps? to form the shape of the pocket [33]. There is a lot of variability among EPSP synthases produced by different species, but essentially all of them have a glycine residue at this important spot in the peptide chain. Studies on the mechanism by which glyphosate disrupts the protein propose that it gets in the way by fitting into the pocket as a faux substrate. However, another plausible explanation is that it is swapped in in place of this especially important glycine residue along the border of the pocket, and its bulky methyl phosphonyl group protrudes into the pocket, crowding out PEP. Very compelling circumstantial evidence comes from the fact that multiple species of plants and multiple species of microbes have independently “discovered” that, if they get rid of the code for that glycine residue (changing it to the closest matching amino acid, alanine), then the enzyme fortuitously becomes completely insensitive to glyphosate exposure, even at high levels. This makes sense because the code no longer matches glyphosate, so no substitution occurs. If glyphosate were instead acting as substrate, the extra methyl group in alanine would not have had such a categorical effect on the sensitivity.

Another remarkable fact is that researchers have played around with over a thousand variants of glyphosate, various molecules that would appear to have a similar shape, but with various tweaks on the chemical structure. None of them were nearly as effective as glyphosate itself at disrupting EPSP synthase [36]. The problem is that none of these variants are amino acid analogues of glycine, and therefore they can’t work the same way glyphosate does.

Glyphosate is not unique in this ability to cause disease through misincorporation into proteins through a coding error. In fact, there are hundreds of naturally occurring amino acid analogues, and many of them have been linked to severe diseases due to substitution for coding amino acids during protein synthesis [37]. ?-Methylamino-L-alanine (BMAA) is a naturally produced amino acid analogue of serine, synthesized by cyanobacteria. It has been hypothesized to misincorporate into proteins in exposed organisms, resulting in protein misfolding. Following an extremely long latency period, this can lead to an ALS-like disease that became endemic in Guam following World War II [38, 39].

Glufosinate, an herbicide that is growing in popularity with the growth in glyphosate-resistant weeds, is a naturally produced amino acid analogue of glutamate, and it is associated with impaired neurogenesis following perinatal exposure due to disruption of glutamate signaling [40]. L-azetidine-2-carboxylic acid (Aze) is yet another naturally produced non-coding amino acid analogue, found in sugar beets, and it is believed to cause multiple sclerosis in exposed humans [41]. Introduction of sugar beet leaves into the feed of lambs resulted in a swayback condition attributed to substitution of Aze for proline in myelin basic protein (MBP), a core protein of the myelin sheath in nerve fibers [42]. MBP contains a highly conserved sequence, PRTPPP, with four proline residues, which causes it to be highly susceptible to Aze toxicity through substitution for one or more of these proline residues. L-canavanine, a toxin found in the seeds of a wild potato plant in Alaska, is an amino acid analogue of L-arginine, and it is suspected to be the cause of the death of Christopher McCandless, the protagonist of the book, “Into the Wild” by Jon Krakauer [43].

AID, Nup98 and Phosphorylation Cascades

Given the growing body of evidence that suggests that glyphosate causes cancer, I have become very interested in the question of how glyphosate could cause cancer. I believe I have found an answer that starts with a triggering of epigenetic regulatory mechanisms that induce a cell to reproduce itself under conditions of stress. A breach in the barrier that protects the nucleus from attack by mutagenic agents leads to suppression of proteins that normally orchestrate a programmed cell death (apoptosis) and uncontrolled expression of proteins that induce proliferation. A regression into a stem-cell-like phenotype completes the picture that leads to rampant growth of a cancer. I find these faulty regulatory control mechanisms to be absolutely fascinating, and glyphosate’s disruption of these natural cellular processes, through widespread incorporation into proteins in place of glycine, can result in not only cancer, but also immune deficiency and autoimmune disease.

Some proteins that cells synthesize have awesome capabilities that can lead to great mischief if they get corrupted. Two of these are activation induced deaminase (AID) and nucleoprotein 98 (Nup98). Under cellular conditions of systemic extreme hyperphosphorylation, these two proteins collaborate to drive a cell into a cancerous state. Phosphorylation is an intriguing mechanism by which cells can modify their proteins and change their behavior, and it involves attaching a phosphate anion to either a serine or a threonine residue within the protein. Some proteins are profoundly affected by such a change, in some cases activated and in other cases inactivated by this small perturbation of the protein’s structure [44].

AID (not to be confused with AIDS!) was only first discovered in 1998, but the number of papers published on AID has been growing exponentially ever since. More and more of its roles in the body are being revealed over time, as well as its ability to cause harm if its expression is misregulated. AID’s specific action is to deaminate a cytosine nucleotide in a DNA molecule. This simple modification can lead to a double-strand break, which is then aggressively repaired by a suite of specialized DNA repair enzymes. However, these enzymes can make a mistake during the repair process, ending up with a DNA mutation, or even a wholesale rearrangement of a chromosome if the wrong ends get sewn together.

AID plays an essential role in the immune system, first, by launching the processes, called somatic hypermutation and class switch recombination, by which specific immunoglobulins in immature immune cells are modified within the thymus during infancy [45]. These raw immunoglobulin templates are eventually converted into an enormous number of variants that can later serve as antibodies to foreign antigens. Later on, at a time when a particular antigen, for example, from an invasive virus, presents itself, AID again becomes active to perfect the shape of the antibody so that it will be able to perfectly recognize and tag the viruses, making them readily visible to other immune cells that will then clear (phagocytose) them. If AID is dysfunctional, these processes will become imperfect, and the immune cells will not be able to optimize the shape of the antibodies. They can potentially end up tagging native proteins rather than foreign proteins, in a pathological process called molecular mimicry, leading to both autoimmune disease and immune deficiency.

AID has also been found to be expressed in some other cells besides the immune cells, most specifically, in cancer cells [46]. So-called “ectopic” expression of AID in cancer cells causes mutations in multiple proteins, which can cause activation of cancer-promoting proteins, such as the Myc oncogene [47], or suppression of proteins that protect from cancer, such as the tumor suppressor, TP53 [48]. Many cancers are associated with loss-of-function mutations in TP53, including colon cancer, breast cancer, lung cancer, lymphoma and leukemia. Over half of all human cancers carry a mutated form of TP53 that no longer functions [49].

TP53 could also be directly affected by glyphosate through a “pseudo-mutation” caused by substitution for a critical glycine residue at location 334 in the sequence [50]. A study on a lung cancer mutation, where the glycine residue at location 334 was replaced with valine, showed that this minor change induced a misfolding of the protein into amyloid fibrils and an impaired ability to form its normal tetrameric configuration [51], thus inactivating it. As mentioned earlier, glyphosate’s documented ability to hypermethylate TP53’s promoter region would also disable expression of the protein [24].

AID can also cause mutations in proteins that would normally induce apoptosis (programmed cell death), preventing them from doing so, and also in the promotor regions of proteins that induce mitosis (cell division), causing them to be permanently expressed and inducing a proliferative state that defines tumor cells. Most remarkably, AID can induce a state of pluripotency, by causing methyl groups to be removed from the cell’s DNA, a first step in reverting a cell to a stem-cell-like status [52]. Such stem-cell-like behavior is a characteristic feature of tumor cells.

Because AID can be dangerous if left unchecked in the nucleus, there are mechanisms in place to retain AID in the cytoplasm and/or to export it from the nucleus, except when it is needed to respond to an infection or other threat [53]. The nucleus is separated from the cytoplasm of the cell by the nuclear membrane. The nuclear membrane is actually riddled with open channels that are created by specialized membrane proteins. These proteins maintain a large number of nuclear pores (holes) where materials can be passaged through the membrane either to be transported from the nucleus into the cytoplasm (e.g., RNA), or to be transported from the cytoplasm into the nucleus (e.g., proteins that regulate DNA expression). These holes are normally plugged by gelled water that is maintained by nucleoporins, one of which is Nup98, which essentially keep large molecules from getting across except when escorted. Specialized transport proteins called importins and exportins can hand-carry specific molecules across the membrane through the gel, essentially by locally melting the gel while traversing the channel [54]. But, in the absence of such assistance, large molecules, such as AID, have to stay put on whichever side of the fence they’re stuck in.

Biological systems are fond of utilizing a strategy that involves minor modification of proteins, in order to change their behavior. This is part of the “epigenetic” influences that have been mentioned frequently in the media as a powerful force in nature. One of these is protein phosphorylation, which involves adding a phosphate group (PO4-2) to a protein. When Nup98 gets hyperphosphorylated (through the addition of multiple phosphates), the plug in the pore completely disintegrates, and it’s a free-for-all in terms of crossing the divide [55, 56].

AID itself uses phosphorylation of a particular serine residue to activate its ability to induce DNA double breaks. And, of course, it has to actually be on the right side of the fence (in the nucleus) in order to have access to the DNA. This is where hyperphosphorylation of Nup98 comes in. Nup98 has an “FG domain” which is a segment of the protein that is highly enriched in phenylalanine (F)-glycine (G) pairs. If multiple serine residues within this FG domain get phosphorylated, Nup98 detaches itself from the pore plug, and this induces a biophysical change that causes the entire plug to disintegrate, essentially opening the floodgates to everybody, including AID, which is normally sequestered in the cytoplasm to keep it from mutating DNA. Glyphosate substitution for glycines within this glycine-rich region would have the effect of introducing a “pseudo” phosphorylation, because, like phosphate, glyphosate carries a negative charge through its phosphonate moiety. Finally, the proteins that add phosphate groups to proteins, called kinases, are also often activated by phosphorylation, and some of these, such as calmodulin kinase II, even activate themselves by adding a phosphate group to their own threonine residue, in a positive feedback loop!

How does a phosphorylation cascade get started? Well, one common way is through excessive calcium uptake by the cell. This is something that glyphosate has been found to induce in both in vitro and in vivo experiments in multiple cell types: Sertoli cells in the testes [57], neurons [28], and cardiac muscle cells [58]. The paper showing increased calcium uptake in neurons demonstrated that glyphosate activated both NMDA receptors and voltage-dependent calcium channels, in part by acting as a glycine analogue [28]. And it also activated the serine-threonine kinase protein, calmodulin kinase II. This in turn launches a flurry of activities that ultimately results in hyperphosphorylation of a large number of proteins in the cell.

Pseudo-phosphorylation through Glyphosate Substitution

Anthony Samsel and I described, in our first paper to discuss glyphosate substitution for glycine during protein synthesis, how glyphosate substitution for critical glycine residues in kinases could be predicted to increase their activity, whereas glyphosate substitution in phosphatases (proteins that remove phosphates) would be predicted to suppress their activity [34]. These effects of course would result in systemic hyperphosphorylation. But, worse than this, glyphosate substitution for certain glycines in proteins that get phosphorylated can be expected to mimic phosphorylation, such that the modified protein acts as if it is per-manently phosphorylated! Serine/threonine kinases have a highly conserved glycine residue right next door to the serine or threonine residue that gets phosphorylated to activate them [59]. Substituting glyphosate for this glycine residue will add a methyl-phosphonyl group carrying a negative charge, which is likely a near-perfect imitation, biophysically, of a phosphate group attached to the adjacent serine residue. Multiple studies have shown that swapping out either the serine residue itself or a nearby amino acid for a negatively charged amino acid (such as aspartate, glutamate or glyphosate) creates a negative charge field that imitates permanent, irreversible phosphorylation on the serine residue [60, 61].

For example, Mayford and colleagues engineered a transgenic mouse to express a variant calmodulin kinase II where the normally present threonine residue at location 286 was replaced by the negatively charged amino acid, aspartate [60]. They showed that the effect was to increase its kinase activity level, just as would be expected to happen if the original threonine residue were phosphorylated. This modification thus produces a version of the protein that does not need calcium stimulation to be activated.

Remarkably, zebrafish have an unusual variant of the AID protein that is missing the serine residue that normally gets phosphorylated, yet it is constitutively active in inducing DNA breaks, as if it were phosphorylated [61]. Researchers hypothesized that the presence of a negatively charged amino acids, aspartate, two residues away from the place where the serine residue should be, had the same effect as serine phosphorylation, producing an enzyme that acted as if it was permanently phosphorylated. The AID protein has seven highly conserved glycine residues [62]. It is in general unpredictable what glyphosate substitution for any of these glycines might do in terms of disrupting protein behavior. However, one of them is near the phosphorylated serine residue, and its substitution by glyphosate would likely activate AID to induce double strand DNA breaks, as has been observed to occur in multiple human- and animal-based models of glyphosate exposure, as discussed previously.

Monsanto’s own studies showed that glyphosate accumulates at the highest concentrations in the bone marrow, where the stem cells that will later evolve into white blood cells reside [35]. These stem cells are precursors to cancer cells in the blood and lymph circulation in cases of leukemia and non-Hodgkin’s lymphoma. These cells naturally express AID as an essential protein involved in their maturation and the perfection of antibodies in response to antigens. It stands to reason that their response to an infection would be over-zealous in the presence of glyphosate, which would cause exuberant phosphorylation of both AID and Nup98, as well as pseudo-phosphorylation of both of these proteins through its introduction of negative charge into the protein by displacing glycine residues. This would lead to a compromised nuclear barrier and infiltration of activated AID proteins into the nucleus where they would induce DNA double strand breaks, the stripping off of methyl groups, and subsequent genetic mutations of critical proteins associated with tumor progression.

As if this weren’t enough, proteins that repair DNA breaks have multiple highly conserved glycine residues that are essential for their proper function. The DNA glycosylase enzyme, OGG1, repairs DNA lesions caused by oxidative damage to the nucleotide guanine, which is the most common defect introduced by DNA exposure to reactive oxygen species. It contains a highly conserved glycine at residue 42. If this residue is replaced by alanine, the protein becomes impaired and DNA breaks accumulate [63, 64, 34].

Another protein, directly involved with repair of double strand breaks, is called MRE11. It has a highly conserved “glycine-arginine domain” which is enriched in glycine residues and contains arginine residues that are methylated to activate the protein [65]. Substitution of glyphosate for any of these glycine residues would be expected to cause unpredictable effects, probably disrupting its ability to repair DNA damage. But hypomethylation is likely also caused by glyphosate, due to its disruption of the supply of methionine and folate, which are essential for methylation pathways.


As I write these words, I have just heard about the victory in the California lawsuit against Monsanto, brought on by Dewayne Lee Johnson, claiming that glyphosate caused his non-Hodgkin’s lymphoma. Johnson was awarded $289 million in a landmark case that hopefully will be the beginning of the end for glyphosate. He won despite the fact that the lawyers could not provide a clear mechanism by which glyphosate might have caused his disease. I believe that the cascade effect of insidious cumulative damage to all the proteins in the body can convincingly lead to conditions such as lymphoma, because of glyphosate’s introduction of oxidative stress, depletion of methylation capacity, and disruption of proteins such as AID and Nup98, as detailed above. AID is prominently expressed in white blood cells, the precursors to the cancer cells that ravaged Lee Johnson’s body.

In the mean time, everyone has a choice at the supermarket. It is fortunate that the United States has a regulatory process that specifies the “certified organic” label, where one strict requirement is to not use glyphosate on the crop. Eating organic can help you and your family sharply reduce the amount of glyphosate you accumulate in your tissues. By buying only certified organic, you become part of a revolution that will force the farmers to switch to organic crops through a market-driven economy. While organic food is more expensive than conventional food, it will save you money down the road on medical bills. And, as more and more people switch to organic, the price will drop due to economies of scale.

We don’t need the government to tell us not to eat toxic food. We can do this all on our own, and if enough of us do, farmers will be able to protect themselves from harm while producing a more wholesome crop that they can be proud of. If you must smoke, you can also purchase only organic cigarettes, and your lungs will thank you for this. So will the children of Argentina who are suffering so much from the toxic exposures they must endure for as long as customers continue to buy cigarettes made from the chemical-laden tobacco their parents currently produce.

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[1] i.e., the probability that this pattern could have occurred by chance is less than 0.00000046.

Don’t Petition and Don’t Register

By Anna Von Reitz

Do not sign petitions and do not voluntarily register anything.

If you are forced to register anything, be sure to get a reference or limitation on the paper with your signature indicating it was not voluntary on your part.

Or make an illegible signature, just a squiggle that nobody could ever read, and if they complain, shrug and say, well, that’s my signature.  Take it or leave it.

That’s what senior postal officials have been doing for years. Doctors too.  There is a method to their bad handwriting skills. And it’s not the Palmer Method.

Most of what we are “forced” to do is done by a simple process of lying to us. They say that we “must” and that it is “the law” and we simply haven’t asked — who says?  And what law promulgated by what organization? And since when am I part of that organization? 

Let’s see…. STATE OF ALASKA, run by the Roman Catholic Church.  Since when did I become a Roman Catholic and subject to that Church’s dictum, taxes, and inquisition?  Or, State of Alaska, run ultimately by the British Monarch?

All the hooks that these predatory organizations have set in you and in your assets have been accomplished by the same process: you are told a lie, you (or your Mother) act upon the lie, and they gain a veiled and highly illegal “interest” in you and your assets without paying a penny. 

They will say that you “voluntarily” enslaved yourself.

As I put it, these vermin have been on our shores “stealing title to our babies” for six generations — and all under false pretenses. 

So here you have proof that the Father of All Lies does exist and his minions, too.

This is why you never serve them as an “Informant” against your own children.  This is why you never voluntarily “Register” anything.  This is why you never sign “Petitions” — which automatically admit that someone other than you has power over you and your life and that you agreed to this. 

Americans are literally born as sovereigns on the land and soil of this country. We need to push that point home into their pointy little heads and stand on it. Record your interest in your Good Name and Estate as part of the international land records, because your Good Name and Estate is a land asset. 

You have no reason and no need to register anything so as to give away your ownership interest in your assets.  Likewise, you have no general need for any trusts. 

The creation of Public Trusts held in your name without your knowledge or consent is how you got into this Mess. Creating a Private Trust to hold your assets is not necessary and for most people is just an additional entanglement. Your Trade Name is already a trust, one that belongs to The United States of America [Unincorporated] and the British minions responsible know what that means in actual fact.  

If you want to get out of the Mess and I do mean — out, out, out — the only kind of trust you need is your own private arrangements stipulating who gets your belongings, who gets to pull the plug if need be, and who acts as Executor of your Estate upon your incompetence, death or permanent disability, established by a properly witnessed Testament.  Two living Witnesses and a Public Notary and that Testament declaring your Will gives you all that you need in terms of trusts.

Take care of your own business, make your own arrangements, record your own claims and instructions, and stop believing all the BS you are being sold by self-interested and undeclared Foreign Agents.

See this article and over 1200 others on Anna’s website here: www.annavonreitz.com

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Drink a tea infused with Korean cactus to naturally remedy your constipation

(Natural News) Treat your constipation naturally with the eastern prickly pear (Opuntia humifusa), a cactus common in Korea. In a study published in the journal BMC Complementary and Alternative Medicine, researchers in Korea wanted to determine if the cactus extract can alleviate loperamide-induced constipation in mice. In Korea, some people drink the juice of eastern prickly…