Social Democratic Union legislator accused of ‘making Jew-hatred respectable’
By Benjamin Weinthal | 8 October 2018
JERUSALEM POST — German politicians on Monday accused Bremen’s Senator of the Interior Ulrich Mäurer of antisemitism and urged him to resign after he said Israel executes Palestinians on the Gaza-Israel border.
“When I see that the Israeli Army is simply executing dozens of Palestinians at the border fence, I don’t understand that either. And I can understand all those who use this opportunity to express their opinions very clearly,” said Mäurer in the Bremen State Legislature on September 27. The 67-year-old politician said he would demonstrate for the Palestinians in light of Israel’s actions.
The vice president of the Christian Democratic Union Party in the Bundestag, Gitta Connemann, told Germany’s top-selling Bild newspaper that Mäurer’s doubling-down on his anti-Israel comment “makes Jew-hatred respectable.” Connemann is also vice president of the German-Israel Friendship Society.
After Mäurer faced intense criticism on social media and from politicians, he told the Bremen paper Weser-Kurier, “In view of the deaths on the border, you have to understand when it comes to demonstrations and protests in response.” […]
(Natural News) Turns out, there’s yet another reason to be wary of saturated fats. A study published in Brain, Behavior and Immunity, a peer-reviewed journal, pointed out that a diet high in saturated fats during adolescence can increase a person’s risk of developing post-traumatic stress disorder (PTSD) as an adult. The study involved 72 adolescent…
(Natural News) A study published in the African Journal of Traditional, Complementary and Alternative Medicines revealed that taking neem oil may help mitigate the risk of suffering from sleeping sickness. A team of researchers at the Kenyatta University in Nairobi, Kenya, conducted a series of in vitro and in vivo assays to determine the beneficial effects of…
(Natural News) To get rid of lingering bad feelings, most people either turn to emotional eating or listen to music. It turns out, there’s a link between these two coping mechanisms, according to the findings of a recent study. Negative emotions are described as unwanted feelings, such as depression and anxiety. It’s part of human nature…
(Natural News) People living in areas with an extremely cold climate might have experienced frostbite at one point in their lives. Frostbite is a nasty condition that occurs when the skin is exposed to temperatures way below its freezing point. Tissue hypoxia, or oxygen deficiency, is the reason behind frostbite. When the body endures extreme cold, it…
FOX NEWS — A Bulgarian journalist who had been reporting on alleged corruption linked to European Union funds, was found raped and murdered on Saturday, authorities said.
Viktoria Marinova, 30, was found dead in a park in Ruse, a town in the far north, along the border of Romania, Reuters reported, citing prosecutors.
Marinova had worked at the Ruse-based TV station TVN as a reporter. She had hosted a recently-launched program, interviewing investigative journalists about alleged corruption between businessmen and politicians involving EU funds. […]
Viktoria Marinova: man arrested in Germany over Bulgarian journalist murder
Marinova’s body was found in a park in the Bulgarian border town of Ruse on Saturday
October is national Breast Cancer Awareness Month in the U.S., and with it comes the annual clarion call of pink-ribboned1 breast cancer awareness campaigns.2 National Mammography Day3 falls on the third Friday of October, which this year is the 19th.
Chances are, you’ve been barraged with reminders that mammograms save lives. Unfortunately, little effort is made to educate women about actual prevention. Detecting cancer has nothing to do with prevention. At that point, it’s already too late.
Vitamin D Optimization Could Eliminate a Majority of Breast Cancer Cases
Generally speaking, research has shown that once you reach a minimum serum vitamin D level of 40 nanograms per milliliter (ng/mL), your risk for cancer diminishes by 67 percent, compared to having a level of 20 ng/ml or less.4
Research shows most cancers occur in people with a vitamin D blood level between 10 and 40 ng/mL, and the optimal level for cancer protection has been identified as being between 60 and 80 ng/mL.
Vitamin D also increases your chances of surviving cancer if you do get it,5,6,7,8 and evidence suggests adding vitamin D to the conventional treatment for cancer can boost the effectiveness of the treatment.9
Several studies also show that higher vitamin D levels are protective against breast cancer specifically. Importantly, a 2005 study10 showed women with vitamin D levels above 60 ng/mL have an 83 percent lower risk of breast cancer than those below 20 ng/mL, and I cannot think of any other strategy that can offer that kind of risk reduction. Mammograms certainly cannot.
More recently, a pooled analysis11 published in June 2018 of two randomized trials and a prospective cohort study came to a near-identical conclusion. The objective was to assess whether there are any benefits to having a vitamin D level above 40 ng/mL, as most studies do not venture into these higher levels.
Indeed, mirroring the 2005 findings, women with vitamin D levels at or above 60 ng/mL had an 82 percent lower incidence rate of breast cancer than those with levels of 20 ng/mL or less.
Pooled data were analyzed in three different ways. First, incidence rates were compared based on vitamin D levels ranging from 20 to 60 ng/mL. Next, statistical analysis using Kaplan-Meier plots were done. Third, multivariate Cox regression was used to examine the association between various vitamin D levels and breast cancer risk. According to the authors:
“Results were similar for the three analyses. First, comparing incidence rates, there was an 82 percent lower incidence rate of breast cancer for women with 25(OH)D concentrations ?60 vs <20 ng/mL.
Second, Kaplan-Meier curves for concentrations of <20, 20–39, 40–59 and ?60 ng/mL were significantly different, with the highest proportion breast cancer-free in the ?60 ng/ml group (99.3 percent) and the lowest proportion breast cancer-free in the <20 ng/ml group (96.8 percent). The proportion with breast cancer was 78 percent lower for ?60 vs <20 ng/mL.
Third, multivariate Cox regression revealed that women with 25(OH)D concentrations ?60 ng/ml had an 80 percent lower risk of breast cancer than women with concentrations <20 ng/mL, adjusting for age, BMI, smoking status, calcium supplement intake, and study of origin …
Higher 25(OH)D concentrations were associated with a dose-response decrease in breast cancer risk with concentrations ?60 ng/mL being most protective.”
Other Studies Linking Vitamin D Status With Cancer Risk
Several other studies also support the hypothesis that higher vitamin D levels are powerful cancer prevention, including but not limited to the following:12
Menopause, 2018 — Just last month, research13,14 published in the journal Menopause found that postmenopausal women who receive a diagnosis of breast cancer are more likely to be vitamin D deficient and overweight than women who receive a negative diagnosis. Overall, breast cancer patients were 1.5 times more likely to have low vitamin D.
The BMJ, 201815 — Earlier this year, a Japanese study published in The BMJ concluded that higher vitamin D levels were associated with a 20 percent lower relative risk of internal cancers in both sexes. Equally important, they found there was no increased risk for any type of cancer associated with higher vitamin D levels.
PLOS One, 201616,17 — This pooled analysis of a randomized trial and a prospective cohort study found that women aged 55 and older who had a vitamin D serum level of 40 ng/ml or greater had a 67 percent reduced risk of cancer compared to those with a vitamin D level of 20 ng/ml or less.
Cancer Causes & Control, 201318 — In this case control study, those who had a vitamin D level of 35 ng/mL or higher were 70 percent less likely to develop breast cancer compared to those with a level of 15 ng/mL or less.
PLOS One, 201119 — Here, women with a vitamin D level of 30 ng/mL or higher had a 60 percent lower risk of breast cancer than those with a level of 20 ng/mL or below. Among post-menopausal women, the risk was 71 percent lower.
Cancer Epidemiology, Biomarkers & Prevention, 200920 — In this case control study, premenopausal women with a vitamin D level of 34 ng/mL or higher had a greater than 60 percent reduction in breast cancer risk compared to those with a level of 24 ng/mL or lower.
Carcinogenesis, 200721 — Postmenopausal women with a vitamin D level of 30 ng/mL had a nearly 70 percent reduced risk of breast cancer compared to those with levels of 12 ng/mL or less.
American Journal of Clinical Nutrition, 2007 — Women over 55 who raised their average serum level to 38 ng/mL lowered their risk of all invasive cancers, including breast cancer, by 77 percent.22
Anticancer Research February 2011 — In this study, breast cancer patients with high vitamin D levels were twice as likely to survive than those with low levels.23,24,25 (Higher vitamin D levels are also associated with a lower risk of severe peripheral neuropathy in cancer patients.26)
This Breast Cancer Awareness Month, Get Your Vitamin D Level Checked
This year, do your breast health a real favor and get your vitamin D level checked. One of the easiest and most cost-effective ways of doing this is to enroll in the D*Action Breast Cancer Prevention project, which now includes both vitamin D and omega-3 testing.
Their new myData-myAnswers personalized health software is now able to “give you feedback on your health conditions compared to thousands of others so you can make more informed decisions on your actions.” GrassrootsHealth also has a handy vitamin D calculator that can help you determine how much vitamin D you need per day to get to 60 ng/mL or above.
You can enroll in this cancer prevention project either on the GrassrootsHealth website, or by ordering the vitamin D testing kit, either alone or in combination with the omega-3 test, from my online store. All revenues from these kits go directly to GrassrootsHealth. I make no profit from these kits and only provide them as a service of convenience to my readers.
As noted on GrassrootsHealth’s D*Action Challenge27 webpage, before you donate money to a breast cancer prevention group, find out whether the group has any focus on primary prevention, opposed to just mammograms. Are they actually trying to eliminate breast cancer, or are they just pushing for detection? Secondly, check to see whether the group recommends vitamin D testing as a key prevention strategy.
Again, research has clearly demonstrated that having a vitamin D level of at least 40 ng/mL, and ideally between 60 and 80 ng/mL,28 can massively reduce your risk of breast cancer.
As noted by GrassrootsHealth, “If the answers are ‘YES’ to both challenges, then the women stand to gain quickly, significantly, safely and inexpensively.” If not, your money is probably not going to do much good, seeing how there’s been no change in breast cancer incidence in over a decade, despite the many millions collected in donations.
According to data published in the Archives of Internal Medicine,29 75 percent of American adults and teens are deficient in vitamin D, based on a sufficiency level of 30 ng/mL. This means at least three-quarters of the female population in the U.S. could lower their risk of breast cancer by 60 to 80 percent.
If the sufficiency cutoff were to be moved to 40 or 60 ng/mL, deficiency rates in the U.S. would likely be in the high 90 percent bracket. The take-home message is that the vast majority of people do not have vitamin D serum levels that are high enough to prevent cancer, and this is so easy and inexpensive to fix!
So, please, if you haven’t done so already, make vitamin D optimization your goal during this year’s breast cancer awareness month, and share the news with all the other women in your life.
Be Mindful of the Interplay of Vitamins D and K2, Calcium and Magnesium
As for how to raise your vitamin D level, remember that the best way is through sensible sun exposure. That said, many will need oral supplementation to achieve an optimal level, especially if you’re pregnant in the wintertime.
Just remember that if you take high-dose oral vitamin D, you may also need to increase your intake of calcium, magnesium and vitamin K2 as well, as these four nutrients work in tandem and rely on sufficient amounts of each to work properly. Importantly, inadequate levels of vitamin K2 in combination with high vitamin D intake may cause overabsorption of calcium, which in turn can result in calcium deposits in your heart and kidneys.
Maintaining an appropriate calcium-to-magnesium ratio30 is also important, as magnesium helps keep calcium in your cells so they can function better. A ratio of 1-to-1 appears to be ideal.
Magnesium is also required for the activation of vitamin D. Without sufficient magnesium, taking a vitamin D supplement may be ineffective,31,32 essentially making it appear you need unnecessarily high amounts. If your magnesium level is too low, the vitamin D will simply get stored in its inactive form, doing you absolutely no good.
According to recent research,33 as many as 50 percent of Americans taking vitamin D supplements may not get significant benefit due to insufficient magnesium levels. On the other hand, when you have an optimal magnesium level, your vitamin D level will rise even if you’re taking a much lower dose.34 To learn more about this, see “Without Magnesium, Vitamin D Supplementation May Backfire.”
Pink-Washing — Beware the Pink Ribbon Scam
While there are many different breast cancer prevention charities, the Susan G. Komen Foundation35 is perhaps the most well-known. It has done a great deal of harm to women by obfuscating the authentic preventative measures available to combat breast cancer and downplaying the preventive role of a healthy diet, vitamin D optimization and limiting chemical exposures, while heavily promoting mammography.
By ignoring the role your lifestyle plays in the development of cancer, organizations such as these can continue to collect billions of dollars of donations in the name of “finding a cure.” Meanwhile, effective prevention could eliminate the need for finding a cure altogether. As noted in a 2014 article by Karuna Jaggar, executive director of Breast Cancer Action:36
“Few people realize that Breast Cancer Awareness Month (BCAM) was launched by Astra Zeneca, a pharmaceutical company that sells cancer treatments on the one hand and carcinogenic pesticides on the other. So BCAM has all along been one big marketing campaign — arguably the most successful marketing campaign of the 20th century.
This is why at Breast Cancer Action, we call October ‘Breast Cancer Industry Month,’ the month when corporations make money professing how much they care about breast cancer by selling pink ribbon products …
How many of the ingredients contained in a random selection of pink products are toxic and bad for our health? No one knows because of weak chemical regulation in the United States that’s outdated …
We can’t waste another October watching corporations make money off pink ribbon products that contain toxins linked to breast cancer. If you are outraged, take a stand to protect all of us from toxic chemicals that are making us sick because the manufacturers of pink ribbon products certainly won’t.”
Mammograms Do More Harm Than Good and Have No Impact on Mortality Rates
Mammography can detect invasive breast cancer in women. This is not in dispute. What is in dispute is whether or not routine mammograms are really the right tool to reduce breast cancer rates, and whether it might harm more women than it helps in the process.
A growing body of evidence suggests that it does in fact, on the whole, do more harm than good by generating high rates of false positives that lead to unnecessary treatment and associated emotional trauma.37 Those who opt for aggressive treatment such as a mastectomy, radiation and/or chemotherapy after a false positive diagnosis undergo physical pain and suffering “for nothing.”
However, since you’re unlikely to ever find out that you didn’t have life-threatening cancer after all, women who believe their lives were saved by mammography will be hard-pressed to buy into the idea that routine mammograms are more harmful than helpful.
Still, statistics suggest many breast cancer survivors are not actually survivors of breast cancer, they’re survivors of breast cancer treatment.38 Several studies have completely demolished the notion that mammograms save lives. For example:
• A 2015 study published in JAMA Internal Medicine39 found mammography screenings lead to unnecessary treatments while having virtually no impact on the number of deaths from breast cancer.
• Another 2015 study40 published in the Journal of the Royal Society of Medicine declares its conclusion right in the title, which reads: “Mammography screening is harmful and should be abandoned.”
In short, decades of routine breast cancer screening using mammograms has done nothing to decrease deaths from breast cancer, while causing more than half — 52 percent — of all women undergoing the test to be overdiagnosed and overtreated. According to lead author Peter C. Gøtzsche, had mammograms been a drug, “it would have been withdrawn from the market long ago.”
• A 2012 study41 in The Lancet concluded that for every life saved by mammography screening, three women are overdiagnosed and treated with surgery, radiation, or chemotherapy for a cancer that might never have given them trouble in their lifetimes. Additionally, no positive correlation with mortality could be found.
Computer Analysis Does Not Improve Accuracy of Mammograms
Research42 also shows the use of computer-aided detection (CAD) for mammography, which is used in 90 percent of U.S. mammograms at a cost of $400 million a year, does nothing to improve the accuracy of the test.
The study looked at more than 625,000 mammograms from nearly 324,000 women to determine whether CAD actually improves a radiologist’s interpretation of a mammogram or not. As it turns out, CAD had no beneficial impact on mammography interpretation, leading the authors to conclude that: “These results suggest that insurers pay more for CAD with no established benefit to women.”
In fact, radiologists were actually more prone to miss cancer when using CAD compared to when not using it. Overall, radiologists correctly identified cancer 90 percent of the time when CAD was not used, and only 83 percent of the time when they used CAD.
Take Control of Your Cancer Risk
In closing, remember to get your vitamin D level checked, and if below 60 ng/mL, take steps to raise your blood level. If you’re looking for a scientifically proven way to avoid being a breast cancer statistic, optimizing your vitamin D is at the very top of the list.
Again, the level you’re aiming for is between 60 and 80 ng/mL, with 40 ng/mL being the low cutoff point for sufficiency to prevent a wide range of diseases, including cancer.
As for dosage, you need to take whatever dosage required to get you into the optimal range. Research43 suggests it would require 9,600 IUs of vitamin D per day to get 97 percent of the population to reach 40 ng/mL, but individual requirements can vary widely. As mentioned, your magnesium status is a very important factor that can play a role in your required dosage, but there are many other individual factors as well.
If you’ve been taking a certain amount of vitamin D3 for a number of months and retesting reveals you’re still not within the recommended range, then you know you need to increase your dosage. Over time, with continued testing, you’ll find your individual sweet spot and have a good idea of how much you need to take to maintain a healthy level year-round.
1 For optimal health, your omega-3 index should be:
Below 8 percent
As close to 100 percent as possible
As close to 1 percent as possible
8 percent or higher
While a general recommendation is to take 3 to 4 grams of marine-based omega-3 per day, the only way to identify your ideal dose is to measure your omega-3 index with a blood test. For optimal health, aim for an omega-3 index of 8 percent or higher. Learn more.
2 Which of the following has NOT been implicated in bee die-offs?
Recent research suggests glyphosate may kill bees by altering the bacterial composition in the bees’ guts, making them more prone to fatal infections. Other factors implicated in bee die-offs include neonicotinoids, parasitic infestations, poor nutrition and habitat loss. Learn more.
3 According to available research, to prevent one case of influenza, how many people must be vaccinated?
To prevent one case of influenza, 71 people must be vaccinated. Meanwhile, one case of flu will be prevented for every 33 people taking a vitamin D supplement. Learn more.
4 Flotation therapy in a sensory deprivation tank can be enormously beneficial in the treatment of which of the following injuries?
Traumatic brain injuries
Sensory deprivation therapy can be enormously beneficial in the treatment of traumatic brain injuries by resetting the neuroendocrine system. Learn more.
5 Which of the following plant fibers is used to make linen?
Flax can be grown for a nutritional seed harvest, and its fiber is used in the making of linen. Learn more.
6 Which of the following formulas help optimize your endurance by ensuring enough oxygen is being put through your body to fuel fat burning rather than sugar burning?
180 minus age
180 minus your age is the heart rate at which enough oxygen is being put through your body to fuel fat burning, and to not put you into glycogen or sugar burning. Learn more.
Research on a flavonoid called fisetin, which contributes to the pigment of fruits and vegetables like apples, cucumbers, grapes, onions, persimmons and strawberries, has been called out for its potential antiaging properties. In experiments performed on lab mice, fisetin was shown to eliminate senescent cells, which accumulate as you age and can be harmful to your body.
While fisetin was discovered years ago, it is one of many diet-derived antioxidants being increasingly investigated for its health-promoting effects. As a plant-based flavonoid, fisetin can be consumed for long periods of time without any known adverse effects. Let’s take a closer look at this promising plant pigment.
What Is Fisetin?
If you’ve not yet heard of fisetin, you are not alone. After all, there are about 6,000 flavonoids from which to choose and each of them contributes to the colorful pigments of fruits, vegetables, herbs and medicinal plants.1 Beyond their role in producing pigments, flavonoids are also antioxidants.
With the continued focus on the value of antioxidants, individual flavonoids are increasingly being recognized for the positive effects they can have on human health. Now, a study published in EBioMedicine2 suggests consuming fisetin at high levels may help you live a longer, healthier life.
In fact, the research, which involved lab mice, suggests the consumption of fisetin may extend your life by as much as 10 percent. Researchers from Scripps Research Institute, Mayo Clinic and University of Minnesota evaluated 10 flavonoids to determine their senolytic activity, calling out fisetin as the most potent.
Fisetin Is Prized for Its Role in Killing Senescent Cells
Though you may not have heard of them, senescent cells are cells that through oxidative damage and aging have lost their ability to reproduce. The study authors defined senescence as a “tumor-suppressor mechanism activated in stressed cells to prevent replication of damaged DNA.”3
They note past studies involving genetic and pharmacologic approaches have shown senescent cells to play a causal role in accelerating aging and age-related diseases. In fact, before putting fisetin to the test, the scientists published research in Aging Cell in 2015 highlighting the flavonoid quercetin for its senolytic activity.4,5
When administered with the chemotherapy drug dasatinib, quercetin was shown to improve age-related conditions such as cardiovascular disease, frailty and osteoporosis. About those results, the study authors said, “The combination of dasatinib and quercetin was effective in eliminating senescent MEFs (mouse embryonic fibroblasts).
In vivo, this combination reduced senescent cell burden in chronologically aged, radiation?exposed and progeroid [syndrome-affected] mice.”6 The researchers also noted “the efficacy of senolytics for alleviating symptoms of frailty and extending healthspan.”7
In terms of underscoring the value of senolytics like fisetin, another study, published in July 2018, affirmed that “senescent cells can cause physical dysfunction and decreased survival even in young mice, while senolytics can enhance remaining health[span] and life span in old mice.”8
Fisetin Shown to Promote Longer Healthspans in Lab Mice
Scientists are interested in fisetin mainly for its usefulness in eliminating senescent cells, an action that could encourage antiaging and promote longer, healthier lives. Senior study author Laura Niedernhofer, director of the Institute on the Biology of Aging and Metabolism at the University of Minnesota (UM), told Newsweek:9
“We’re looking for drugs that can kill these damaged senescent cells that are very toxic to our bodies and accumulate as we get older. It turns out that fisetin is a natural product that actually we were able to show very selectively and effectively kills these senescent cells, or at least dials back their bad secretions or inflammatory proteins.”
According to Newsweek, as senescent cells accumulate in your body, they can cause both inflammation and tissue degradation.10 Acting as a senolytic agent, fisetin may be able to kill senescent cells in humans just as it has been shown to do in aging mice.
Paul Robbins, Ph.D., UM professor of biochemistry, molecular biology and biophysics and associate director of the Institute, commented:11
“The mice reached an extension of life span and healthspan of over 10 percent, that’s pretty remarkable. At the dose we used, the question is if we could give them a lower dose or more infrequently. That’s a theoretical advantage of using these types of drugs that can clear the damaged cells — you can use them intermittently.”
Fruits and Vegetables Containing Fisetin
Even though fisetin is naturally occurring in a number of fruits and vegetables, you will likely not be able to obtain therapeutic amounts of this flavonoid from food alone. While scientists continue working out the proper dosing for fisetin, there is, however, little harm in — and possibly much benefit to — adding some of these fisetin-containing foods to your diet:12,13
As you can see, strawberries are by far the best food source of fisetin, but you’d need to eat about 37 whole berries to get a decent amount of benefits. (One supplement brand, which I cannot endorse, even uses the wording “37 strawberries” in their product name.) Obtaining an optimal amount of this, or other flavonoids, from food sources is, unfortunately, not always realistic.
While a small 1998 Japanese study14 estimated the average daily intake of fisetin to be just 0.4 milligrams (mg) in that country, figures are not yet available to track fisetin consumption by Americans. Additionally, recommended dietary intakes for fisetin do not exist.
For now, as noted by Robbins, knowing that fisetin can have a positive impact on damaged cells is good news even as more work, including a series of human medical trials, is needed.
He stated, “These results suggest that we can extend the period of health — termed ‘healthspan’ — even toward the end of life. But there are still many questions to address, including the right dosage, for example.”15
Some of the Health Benefits of Fisetin
As noted in the Journal of Nutritional Science, the interest in the health-boosting effects of flavonoids, including fisetin, continues to grow. The study authors asserted:16
“Flavonoids are now considered as an indispensable component in a variety of nutraceutical, pharmaceutical, medicinal and cosmetic applications. This is attributed to their antioxidative, anti-inflammatory, antimutagenic and anticarcinogenic properties, coupled with their capacity to modulate key cellular enzyme function.”
Already, a number of fisetin supplement brands exist, touting some of the health benefits noted below.17 To date, fisetin has been shown to:
Encourage anti-inflammatory action — Fisetin has been shown to suppress the production of inflammatory cytokines. While noting a flavonol-rich compound containing fisetin could be a potential therapeutic agent in the treatment of inflammatory conditions, one group of study authors noted:18
“In experimental inflammation-related models, flavonol-rich RVHxR (Rhus verniciflua Stokes) and fisetin have shown significant anti-inflammatory activities on vascular permeability, leukocyte migration and cellular immunity.
Also, flavonol-rich RVHxR and fisetin treatments significantly reduced the incidence and severity of [the] collagen-induced arthritis model.
These results suggest RVHxR and its major compound fisetin have shown potent suppressive effects on some inflammatory cytokines/chemokines and angiogenic factor in [Interleukin 1 beta]-stimulated rheumatoid arthritis FLS (fibroblast-like synoviocytes) and inflammatory in vivo models.”
Help prevent cancer — Given its well-known anti-inflammatory, antioxidant and antiproliferative properties, fisetin can play a role in helping to prevent cancer. To date, among other effects, fisetin has been shown to:
Activate particular signaling pathways to induce cell death (apoptosis) in cervical cancer cells19
Exhibit antigrowth potential against lung cancer cells20 and prostate cancer cells21
Induce apoptosis in colon cancer cells by inhibiting certain signaling pathways23
Inhibit bone-damaging glycation — Glycation, a process in which sugar molecules bond to certain proteins and lipids in your body, results in bone-damaging Advanced Glycation End (AGE) products.
According to natural health expert Vivian Goldschmidt, founder of the Save Institute, a branch of which focuses on osteoporosis prevention, these molecules destroy collagen, the cartilage-like material that gives your bones tensile strength.24 Due to its beneficial interaction with proteins found in your body, one study indicates fisetin arrests the glycation process.25
Maintain your glutathione levels — According to a 2009 study published in the journal Genes & Nutrition, fisetin has been shown to help maintain your glutathione levels, particularly during times of increased oxidative stress.26
The study authors stated, “Fisetin not only has direct antioxidant activity but it can also increase the intracellular levels of glutathione, the major intracellular antioxidant.”27 Goldschmidt asserts glutathione “has the most electrons of any antioxidant, so it can ‘donate’ more of these electrons to free radicals in order to neutralize them.”28
Protect your brain function — A 2014 study published in Aging Cell29 suggests fisetin may have the ability to stave off age-related memory associated with Alzheimer’s disease and other types of dementia. The researchers suggested fisetin can act on many of the target pathways implicated in Alzheimer’s disease.
They also found oral administration in mice aged 3 to 12 months prevented the development of learning and memory deficits. The study authors suggested “our results demonstrate fisetin, a compound that activates multiple, well-defined neuroprotective pathways, may provide a new approach to the treatment of [Alzheimer’s disease].”30
As noted in the featured video, fisetin is one of the few substances capable of crossing your blood-brain barrier. (Curcumin, a polyphenol with neuroprotective qualities, is another.)
Slow the progression of Huntington’s disease — In animal studies, fisetin has been found to slow the progression of Huntington’s disease, an ultimately fatal neurodegenerative disorder characterized by cognitive, motor and psychiatric symptoms.
Pathways implicated in the disease include those involving mitogen-activated protein kinase signaling and, particularly, the Ras-extracellular signal-regulated kinase (Ras-ERK) cascade. Based on 2011 experiments involving three disease models, fisetin was shown to reduce the impact of the mutant huntingtin gene.31
The study authors noted both fisetin and resveratrol activated the ERK pathway, “thus suggesting that polyphenols and/or their derivatives might be useful for the treatment of [Huntington’s disease].”32
Stabilize resveratrol — Similar to other flavonoids, fisetin has been shown to inhibit the hepatic and duodenal sulphation of resveratrol,33 thus improving the bioavailability of this powerful anti-inflammatory polyphenol found in red wine and the skins of certain fruits.
Says Goldschmidt, “Fisetin acts as a shield for resveratrol, slowing its breaking down and being metabolized in the liver. Thus, fisetin actually increases the amount of resveratrol in the blood.”34
What’s Next for Fisetin?
Fisetin is currently undergoing clinical trials at Mayo Clinic, which means some more conclusive information about recommended dosing could become available at some point in the future. One of the current trials35 seeks to evaluate markers of frailty and inflammation, as well as bone resorption and insulin resistance in older postmenopausal women.
The study involves 40 women, ages 70 to 90, who are affected by gait disturbance. Half of the women are receiving an oral dose of 20 mg of fisetin per kilogram of body weight per day for two consecutive days, for two consecutive months, while the other half is receiving a placebo according to the same time schedule.
The trial began in February 2018 and will conclude in June 2020. According to the researchers, “Positive results of this study would lead to the development of a larger clinical trial examining the effects of this intervention on age-related dysfunction.”36
Given the many health benefits of fisetin, I highly recommend you regularly add a serving of organic strawberries (or another fisetin-containing food) to your diet. Given the fact a 1-cup serving (152 g) of strawberry halves contains just 3.8 g of fructose, you can easily incorporate this delicious, nutritious fruit into your eating plan and still moderate your fructose levels.
As you may recall, I advise you limit fructose from all sources, including whole fruit, to 25 mg a day if you are healthy and less than 15 mg if you are dealing with a chronic illness like cancer or diabetes.
Also, when buying strawberries from the store, keep in mind conventional varieties are sprayed with a number of toxic pesticides, including chemicals known to cause cancer and reproductive damage, so be sure to purchase organic and wash them well before eating.