So what’s all this about a “Missing Dog Named GUMBO”?? Deep state codings, it seems… (via Bill Smith News, 6-7-19)

[Kp update: this WDiM has a number of links to recent “suicides”, etc., and may be helpful for the links it contains.]

This one “struck pretty strongly to post, as it shows a) one way the deep state (Democrat) is coding messages, and b) the deep state (Democrat) desperation. The video (short one) goes through this pretty well, and when I looked up Donna Brazile on WikiPedia, it does show she was born in New Orleans, and her Twitter account indicates her love for gumbo. Then all the connections made with DNC people… Well, tie this in with all of the recent “suicides” (including HRC’s youngest brother), well, it sounds like desperation.

Once again, the idea here is to Shine Light on all that is going on here, as well as remain IN the Light.

QANON 6/6/19: Missing Dog Named GUMBO – Is this Donna Brazile’s CodeName??
.

https://youtu.be/tdc0ThSM34c

Premiered Jun 7, 2019
Is Donna Brazile’s codename “Gumbo”?
There’s a DNC campaing to find a lost dog name Gumbo in Atlanta.
Contact FindGumbo@gmail.com if you see Donna Brazile in Atlanta this weekend.

Twitter Links from Famous Peeple about “lost dogs”.
https://twitter.com/Comey/status/1062853932576321538

RIP Isaac Kappy:
https://twitter.com/sethgreen
https://twitter.com/SethGreen/status/…
https://twitter.com/robgo84/status/11…
https://twitter.com/robgo84/status/11…

Famous DNC people look for Gumbo:
https://twitter.com/BarackObama/statu…
https://twitter.com/CoryBooker/status…
https://twitter.com/KamalaHarris/stat…
https://twitter.com/Adrienne_DNC/stat…

Bungo – Tales of the Lost Dogs

https://www.crunchyroll.com/anime-new…

Donna Brazile – I hope you have good life insurance..
https://twitter.com/search?q=%40donna…

TracyBeanz is a shill: “I don’t support and internet bill of rights”
https://twitter.com/tracybeanz/status…

Weekly health quiz — CBD, homeopathy and 5g

1 Which of the following nutrients has not been shown to protect skin from ultraviolet damage?

  • Vitamin E
  • Vitamin A

    Scientists have identified several nutrients that have UV protective activity, reducing your risk of sunburn and related skin damage, including astaxanthin, vitamins D and E, lycopene and epigallocatechin gallate (EGCG). Learn more.

  • Lycopene
  • Astaxanthin

2 Which of the following plants is cannabidiol (CBD) derived from?

  • Poppy
  • Hemp only
  • Cannabis and hemp

    CBD is the nonpsychoactive component of cannabis and hemp. Unlike the THC in cannabis, CBD does not induce a high, but has many clinical benefits, including the control of seizures and pain. Learn more.

  • Cannabis only

3 Which of the following has been shown to be an effect of millimeter wave exposure, used in 5G?

  • Hypotension (low blood pressure)
  • Cold flashes; sensation of freezing
  • Successful cancer treatment
  • Burning sensation; pain

    5G relies primarily on the bandwidth of the millimeter wave, known to cause a painful burning sensation. It’s also been linked to eye and heart problems, suppressed immune function, genetic damage and fertility problems. Learn more.

4 Recent research showing Alzheimer’s disease is a double-prion disease found the following scenario had the strongest correlation to dying prematurely:

  • High amounts of tau buildup

    Higher levels of prion-like amyloid beta and tau were found in those with early onset of Alzheimer’s who died at an earlier age, with tau buildup showing the strongest correlation. Compared to a patient who died of Alzheimer’s at the age of 90, a patient who died at 40 had on average 32 times higher amounts of tau prions in their brain. Learn more.

  • Low amounts of tau buildup
  • Low amounts of amyloid beta plaque
  • High amounts of amyloid beta plaque

5 Research suggests shows gardening can help improve cognitive function by:

  • Interrupting rumination
  • Increasing brain nerve growth factors

    Research also shows gardening can help improve cognitive function by increasing brain nerve growth factors such as BDNF. Learn more.

  • Engaging effortless attention
  • Exposing you to beneficial microorganisms

6 Homeopathy is believed to work:

  • by the placebo effect
  • by the action of greatly diluted nanoparticles
  • by water absorbing energy of the substance

    Homeopathy is believed to work by water’s ability to absorb the energy of a substance. Learn more.

  • by treating a disease with opposite drugs

7 The following may be a contributing factor that gets overlooked in many cases of fibromyalgia:

  • Enzyme G6PD insufficiency
  • Glyphosate exposure
  • Calcium deficiency
  • High oxalate levels

    Elevated oxalate is a common cause of chronic pain and fibromyalgia. One way to lower your oxalate level is to take Epsom salt baths, as the sulfate will displace the oxalates. Learn more.

Could cranberries combat superbugs?

Finding a drug to either kill harmful bacteria or slow their growth has been a priority for medical practitioners for thousands of years. Not all antibiotics have been effective or even safe, although herbs, honey and moldy bread poultices used in ancient Greece, Rome, China and Egypt were used with some success.1

Needless to say, as scientists experimented with treatment possibilities and resorted to things like animal feces, heavy metals like mercury, bismuth and arsenic to eradicate sexually transmitted diseases such as gonorrhea and syphilis via specially designed syringes, the “administration and side effects often proved worse than the disease.”2

The Journal of Antimicrobial Chemotherapy references many attempts over centuries to nail down a definitive antibiotic, and several showed great promise, such as Pyocyanase, derived from a green bacteria isolated from injured peoples’ bandages, which slowed the growth of other microbes. “They grew the organism (Pseudomonas aeruginosa) in batches and used the supernatant as a medicine, with mixed success.”3

Sulfa drugs such as a prominent one called Prontosil, first tested in 1935, also showed promise.4 At times, catastrophic illnesses made the search more desperate, as when an herb called qinghaosu (artemisinin) used for millennia in traditional Chinese medicine (TCM), was tried and found to be a potent treatment for malaria as late as the 1970s.5

But since the discovery of penicillin in 1929 and its mass production and distribution in 1945,6 not only the study of medicine has changed, but the world.

Frontiers in Microbiology suggests that antimicrobials could be called the most successful chemotherapy agents since the study of medicine began, noting, “It is not necessary to reiterate here how many lives they have saved and how significantly they have contributed to the control of infectious diseases.”7

‘Germs will always look for ways to survive’

However, overuse has created a dire situation: The successes have been “marred by the emergence of hard-to-treat multiple antibiotic-resistant infections.”8 In fact, as the U.S. Centers for Disease Control and Prevention observes, “Germs will always look for ways to survive and resist new drugs.”9

According to researchers at McGill University, antibiotic resistance is undermining decades of progress in fighting bacterial infections. Antibiotics are used not only in medicine but in agriculture. In fact, methicillin-resistant Staphylococcus aureus (MRSA) and other superbug infections have been spreading rapidly among people both inside and outside of hospital settings.10 McGill scientists asserted:

“We are on the cusp of returning to a pre-antibiotic era in which minor infections can once again become deadly. Therefore, countering the fall in antibiotic efficacy by improving the effectiveness of currently available antibiotics is a crucial goal.”11

But in May 2019, a familiar plant-based product was found to make bacteria more sensitive to antibiotics and prevent resistance. Testing the popular belief that cranberries, even more than the juice, might be effective agents against painful and often debilitating urinary tract infections (UTIs),12 the researchers wanted to see how its compounds would stand up against some of the most virulent strains.

Cranberries are tapped to help fight pathogenic bacteria

The journal Advanced Science13 reports that cranberries — or more specifically, the proanthocyanidins in cranberries — are very effective in the fight against pathogenic bacteria. EurekAlert explains results from the study:

“Countering the fall in antibiotic efficacy by improving the effectiveness of currently available antibiotics is a crucial goal … When treated with molecules derived from cranberries, pathogenic bacteria become more sensitive to lower doses of antibiotics. What’s more, the bacteria don’t develop resistance to the antibiotics.

Given the popular belief that drinking cranberry juice is helpful against urinary tract infections, the researchers sought to find out more about the berry’s molecular properties by treating various bacteria with a cranberry extract. The bacteria selected for study were those responsible for urinary tract infections, pneumonia, and gastro-enteritis (Proteus mirabilis, Pseudomonas aeruginosa, and Escherichia coli).”14

According to Nathalie Tufenkji, McGill chemical engineering professor and the study’s lead author, “Normally when we treat bacteria with an antibiotic in the lab, the bacteria eventually acquire resistance over time.” But when her team treated these bacteria with a combination of an antibiotic along with a cranberry extract, they were surprised to be able to report that “no resistance developed.”15

The researchers wrote that cranberry proanthocyanidins, which they called CPAC, prevent not only the “evolution of resistance” to tetracycline in Escherichia coli and Pseudomonas aeruginosa, but “rescues antibiotic efficacy” when posed against cells exposed to antibiotics and, further, inhibited biofilm formation.

Further study revealed the resistance happened two ways: First, the cranberry extract made the bacterial cell wall more permeable so the antibiotic could reach it, and second, it rendered the bacteria less able to get rid of it. As such, the antibiotic was more effective at lower doses. In addition:

“After confirming the activity of the cranberry molecules on bacterial culture, the researchers tested to determine whether the pattern persisted in a preliminary animal model: infected insects. Since the synergistic effect of the extract and the antibiotic was also observed in the insects, further experiments will be conducted to clearly identify the active molecules.”16

What are cranberries good for? Researchers weigh in

There’s been some controversy regarding the efficacy of cranberries for bladder infections, but increasingly, the positive research on cranberries begins to make more sense when you find how many diseases and disorders the small, tart red fruit can benefit. Here are a few important ones:

Cardiovascular disease — The impacts of cranberries on not just the cardiovascular system but every component of metabolic syndrome was explored in a 2017 review. It listed several areas impacted, including reduced obesity markers (body weight, body mass index and waist circumference), blood pressure and balanced blood sugar levels.17

Cancer — A 2016 review on what compounds in cranberries can do for cancer noted that 17 different types, including cancers of the colon, bladder, prostate, esophagus and stomach, as well as glioblastoma and lymphoma, were inhibited by cranberries or cranberry-derived constituents.

Cranberries may fight cancer, in part, due to apoptosis, necrosis and autophagy due to “reduction of cellular proliferation; alterations in reactive oxygen species; and modification of cytokine and signal transduction pathways.”18

Oral health — Proanthocyanidins in cranberries may help prevent bacteria from binding to teeth and prevent gum disease, one study notes. “Clearly, cranberry (proanthocyanidins) show promise for the development of novel alternative or adjunctive anticaries chemotherapy.”19

Ironically, cranberry juice was a popular remedy recommended by doctors for many years for UTIs, but more recent research suggests that the placebo effect might have accounted for the successes the use of cranberry juice elicited more than solid science,20 especially since its active ingredient is likely “long gone before it reaches your bladder,”21 one researcher explains.

What problems can antibiotics cause?

Research in 201822 showed that, particularly for children, antibiotic use can cause short-term problems, but they also can trigger a permanent change in your gut microbiome, which accounts for nearly 80 percent of your immune system function, so it is important to use antibiotics only when absolutely necessary.

They’ve also been found to cause mitochondrial dysfunction and overproduction of reactive oxygen species (ROS) in human cells, DNA and vital organs.23 But that doesn’t stop doctors from prescribing them — often unnecessarily. The CDC notes:

“In 2015 alone, approximately 269 million antibiotic prescriptions were dispensed from outpatient pharmacies in the United States, enough for five out of every six people to receive one antibiotic prescription each year. At least 30 percent of these antibiotic prescriptions were unnecessary.”24

As if that weren’t enough, besides ruptured tendons, kidney stones and/or failure, retinal detachment and blindness, and ruptured aorta (the main artery supplying oxygenated blood to your circulatory system), research emerged that antibiotics can also raise the risk of mental disorders, such as schizophrenia, autism and numerous personality and behavior disorders.25

Fluoroquinolones are a type of antibiotic often prescribed for upper respiratory and urinary tract infections. However, because of the damage they’ve been known to cause, from acute kidney failure to psychotic reactions to “fatal events,”26 antibiotics — and fluoroquinolones in particular — should be used only as a last resort.

More on the dangers of overusing antibiotics

The U.S. Food & Drug Administration (FDA) issued a warning in 2017 about an increased risk of ruptures or tears in the aorta due to the use of fluoroquinolones in certain patients.27 In 2018, the journal Nature mentioned the commonly prescribed drug causes “rare but disabling” side effects, noting that in 2015, doctors prescribed them 32 million times, making them the fourth-most popular antibiotic in the U.S. Further:

“Fluoroquinolones are valuable antibiotics, and safe for most people. Yet they are so widely prescribed that their side effects might have harmed hundreds of thousands of people in the United States alone, say scientists who are working with patients to unpick FQAD’s causes.

Fluoroquinolone toxicity, they say, provides a compelling example of an emerging understanding that antibiotics don’t just harm microbes — they can severely damage human cells, too.”28

Antibiotic use for two months or longer by women aged 60 and older has been shown to lead to a 32% increased risk of developing cardiovascular disease, including heart attack and stroke. It’s important to note the likely reason: Antibiotics have the power to not only alter your gut, but “wipe out” your microbiome.29 Interestingly, the study concludes:

“The intestinal microbiome appears to play an important role in atherosclerosis. These findings raise the possibility of novel approaches to treatment of atherosclerosis such as fecal transplantation and probiotics.”30

One of the best and least expensive ways to optimize your gut microbiome is to eat traditionally fermented and fiber-rich foods. But there’s also spore-based probiotics, aka sporebiotics, which make use of the microbe Bacillus to dramatically increase your immune tolerance.

If you must take antibiotics, I recommend taking the beneficial yeast Saccharomyces boulardii after you’ve finished to prevent secondary complications of antibiotic treatment, such as diarrhea.

Top benefits of rooibos tea

Tea may be drunk hot or cold but, either way, it’s made by infusing the dried crushed leaves of the tea plant in boiling water. Rooibos (pronounced “roy-boss”)1 is made from the fermented leaves of the Aspalathus linearis, which is native to South Africa.2 According to the South African Rooibos Council,3 it’s not a true tea but, rather, a fermented and dried herb.

The tea is red in color and is sometimes referred to as African red tea, or red bush tea.4 It’s been a popular beverage in Africa for centuries and has a sweet honey taste with a rich red hue. Green rooibos is green-brown in color and has a grassy flavor similar to green tea.

Both red and green rooibos teas are caffeine-free and have low levels of tannins, which are substances that may trigger migraines or allergies in those who are sensitive.5 More recently it’s gained popularity with tea drinkers as it is a palatable alternative to green and black tea, both of which can have a bitter taste.

The methods used to make organic rooibos tea are similar to those used more than 100 years ago. After being harvested, the stems and leaves of the Aspalathus linearis are bruised and left to ferment and oxidize.6

The fermentation process gives the tea its distinct reddish-brown color. Keep in mind, though, there are other types of beverages also called red tea that are not rooibos, including some black teas and hibiscus tea. When the tea is not fermented, it’s characterized by a green color and a grassy flavor.7

Although it undergoes less processing, green rooibos tea is often more expensive than the red variety and contains higher amounts of antioxidants.8 The flavor of red rooibos makes it perfect for a dessert tea,9 and significantly healthier than sugar-laden drinks and cakes.

History of rooibos tea

Botanists first identified rooibos tea in 1772, but it was a housewife10 named Annique Theron who put South Africa’s red tea on the map when she discovered it could calm and soothe her colicky baby when she added it to her breastmilk. She was subsequently awarded an honorary doctorate for her discovery. The South African Rooibos Council credits Theron — who later became a businesswoman selling health and beauty products — with popularizing what has become a go-to remedy.11

The tea began gaining popularity in the U.S. during World War II, a time when importing tea from Asian countries was nearly impossible. It became an excellent alternative, but the price remained high as the seeds were scarce.12

In 1930 a local medical doctor and an amateur botanist discovered the secret of germinating the seeds, and together with a commercial farmer, developed cultivation methods that allowed them to produce rooibos on a larger scale.13

In 1980, Japanese and American scientists discovered the tea contained a powerful antioxidant and, in 1995, a medical doctor together with a South African research company discovered the tea had antiviral, anti-allergic, anti-inflammatory and antibacterial properties.14 By 2003, rooibos tea was fully established and growing in popularity in the U.S. and Europe.

Rooibos tea flavor varies depending upon botanical content of the herb

While there’s a distinct flavor difference between red and green rooibos tea, scientists have also found a compound that contributes to the taste and feel of fermented rooibos tea. The compound, Z-2-(?-d-glucopyranosyloxy)-3-phenylpropenoic acid (PPAG), has been isolated from unfermented plant material.

Researchers found a similar compound, and analysis of the leaves of a large number of plants showed PPAG was not uniformly present in detectable quantities in the leaves of different plants on the commercial plantation.15

During fermentation, there was a large variation in PPAG, subsequently found in infusions and food grade extracts. Researchers found it adds a slightly bitter to astringent taste to the tea, which may account for the difference in flavor in rooibos tea purchased from different manufacturers.16

This rare acid is one of the major constituents in fermented infusions and has been shown to enhance insulin release and glucose uptake in muscle cells. The results of one study17 suggest the liver is the primary target organ for bioactivity and describes how PPAG increases glucose uptake in a test tube and improves glucose tolerance in rats.

Hypoglycemic effect helps stabilize blood sugar

Rooibos has a flavonoid profile distinctly different from those found in Camellia sinensis, from which traditional tea is derived. In addition to PPAG, rooibos tea also contains aspalathin, a component of the Aspalathus linearis plant. The effects of aspalathin, found in green rooibos tea, were evaluated in a study published in Phytomedicine.18

Scientists looked at glucose metabolism in vitro and in vivo. In the first stage they examined the effect on glucose uptake on cultured cells and insulin secretion from pancreatic beta cells. Subsequently, the researchers used mice with Type 2 diabetes and found aspalathin significantly increased glucose uptake and insulin secretion in a dose-dependent manner.19

A second study20 found aspalalinin, which currently has only been isolated in rooibos, and a variety of other flavonoids and flavanols, including quercetin and chrysoeriol, have been isolated from the red bush. The process of fermentation gives the tea its unique reddish-brown color.

However, tea brewed from unfermented green rooibos is reported to have higher antioxidant capacity and richer bioactive constituents.21 This rich source of unique antioxidants may play a role in exerting beneficial effects against the pathophysiology of diabetes and diabetic complications.

When fermented and administered to diabetic rats, rooibos reduced biochemical markers characterizing liver toxic effects and suppressed lipid peroxidation and enhanced glutathione-peroxidase in the blood and liver.22

Other studies have confirmed the aspalathin in rooibos can modulate glucose metabolism, suppress elevated fasting blood glucose and alleviate impaired glucose tolerance.23

Antioxidant levels of rooibos tea may contribute to multiple health benefits

Antioxidants are sometimes called free radical scavengers as they are substances that may prevent or slow damage to your cells triggered by free radicals. Plant-based antioxidants are phytonutrients or plant-based nutrients.24 Free radicals are waste products normally produced by your cells during the process of metabolism.

Your body needs a way to remove free radicals efficiently or oxidative stress may result, harming cells and increasing your risk of disease. Oxidative stress has been linked to heart disease,25 cancer,26 arthritis,27 stroke28 and neurological disease.29 Antioxidants help neutralize free radicals, which ultimately helps to boost your overall health.

Free radicals may be produced during mitochondrial activity, excessive exercise, tissue trauma and exposure to smoke, environmental pollution or toxic chemicals. A plant-based diet protects against chronic stress by increasing your antioxidant content.30

One way of evaluating the amounts of antioxidants found in your food, especially fruits, is by slicing them and exposing the content to air.31 If they turn brown, they’re oxidizing and likely don’t have a lot of antioxidants. Adding lemon juice, high in vitamin C, may keep your food from oxidizing, and may do the same thing inside your body.32

The fermentation process causes some loss of antioxidants, which is why green rooibos contains higher levels of polyphenols. Rooibos tea contain flavonoids, phenolic acid, quercetin and luteolin, all of which are powerful antioxidants. According to the American Botanical Council,33 a 6-ounce serving of rooibos tea may have up to 80 milligrams of total polyphenols.

Anti-inflammatory properties contribute to pain relief

Inflammation and the release of cytokines is an attempt by your body to protect itself and begin the healing process. Infections, wounds and tissue damage may trigger an inflammatory response and subsequently pain.34

Cytokines are one measurement of inflammation in the body and may be linked to the severity of pain.35 In several studies,36 researchers found baseline elevations of proinflammatory and anti-inflammatory cytokines, and when proinflammatory cytokines markers were higher it was associated with a greater degree of pain.

Research published in the Journal of Inflammation37 found the use of rooibos tea had an anti-inflammatory effect on a systemic level. Another animal study38 concluded rooibos tea may prevent DNA damage and inflammation via antioxidative activity.

Since the tea is free of caffeine, the researchers suggested routine consumption may be safe and useful in reducing oxidative stress in children. Another study39 concluded rooibos tea had dual function on inflammation and had the ability to promote the production of nitric oxide.

More rooibos tea health benefits are related to anti-aging factors

The use of rooibos tea has been cited for being helpful in lowering blood pressure and relaxing tense muscles.40 This is likely related to the increased nitric oxide production after consumption. In one study,41 cultured cells from human umbilical veins were incubated with rooibos tea and the cells were examined for their effect on angiotensin converting enzyme and nitric oxide.

After incubation for 10 minutes there was a significant dose-dependent inhibition on angiotensin-converting-enzyme with green tea and black tea but not rooibos tea. After 24 hours, there was a positive effect on the production of nitric oxide with rooibos tea.

In an animal study,42 researchers found rooibos tea had the ability to reverse stress-related metabolites and restore stress-induced protein degradation. In a human study43 using 17 healthy volunteers, researchers evaluated oral intake of a single dose of rooibos tea and found it had cardiovascular effects through the inhibition of angiotensin converting enzyme activity.

A literature review44 looking at past studies found differences and inconsistencies in the amount of nitric oxide produced. The scientists attributed this to common occurrences from in vitro and in vivo studies, and differences in the concentrations tested.

According to the researchers, another factor contributing to such differences may have been related to variations in the different batches of rooibos tea sampled, as they found chemical composition differed depending on the botanical species, the part of the plant used, storage methods and agricultural practices. They concluded that while nitric oxide was produced, there was a variation in the amount.45

In addition to cardiovascular health, rooibos tea has also been associated with reducing oxidative stress in the liver46 and protecting cells against the natural aging process. Antibacterial compounds, antioxidants, vitamins and minerals all work to help improve skin texture, quality and health.

The reduction in systemic inflammatory response47 also helps protect your skin, and according to Reader’s Digest, acne and eczema sufferers have reported rooibos tea helps improve these conditions.48 Rooibos tea is also naturally high in calcium, manganese and the antioxidants orientin and luteolin, which help maintain good bone structure and strong teeth.49

Rooibos may improve male fertility

Although researchers are coming to a consensus that men in America and Europe are experiencing a drastic decline in fertility,50 they have not agreed on a single cause. Studies released in 2018 support past research finding motility, or the ability of the sperm cells to swim, has declined in the past decade.51

In other studies,52 researchers have found the application of rooibos tea to animal semen in vitro increased sperm velocity, membrane integrity and protected the structure.

In an in vivo study53 on male rats, researchers found treatment with rooibos improved sperm concentration, viability and motility, which they hypothesize might have been attributed to the high level of antioxidants. A third study54 using rats with diabetes found the application of rooibos improved sperm health, including velocity and motility.

How to store, brew and drink rooibos tea

As with any other herb, rooibos should be stored properly to maintain freshness and viability. While it may not ever go “bad,” it may get stale and taste weak and musty. Be sure to purchase your rooibos from a reputable company that can tell you how the tea was processed and packaged and when it was harvested.

Since it is oxidized in a fashion similar to black tea, it technically stays fresh for up to two years when stored correctly.55 Take care to keep it in a cool dark place, away from light, oxygen, moisture and any fragrant foods, such as coffee or spices.

To brew a great cup of rooibos tea, use fresh, pure filtered water. If you purchase a good quality loose leaf tea it may be infused at least twice. Your tea likely came with specific recommendations for brewing you should use. Generally, 2 grams of loose tea leaf for every 8 ounces of water will give you a tasty cup.

Rooibos is infused at temperatures from 200 to 212 degrees Fahrenheit. Cover the pot while the tea is infusing to keep the heat inside the vessel. Taste it after the recommended time and decide if you’d like it a little stronger. Unlike other traditional teas, rooibos will not taste more astringent or bitter the longer it’s in hot water, it only gets stronger and more flavorful.56

Some recommend adding milk or cream with the tea.57 However, researchers have found simultaneously ingesting dietary proteins, such as casein found in milk or cream, reduces the bioavailability of the catechins found in the tea,58 and therefore may reduce its health benefits.

The crucial connection between magnesium and vitamin B6

You may be familiar with the connection between magnesium, calcium and vitamins K2 and D, and how they work in tandem. But are you aware of the crucial link between magnesium and vitamin B6 (pyridoxine)? Individually, magnesium and vitamin B6 are both essential for heart and brain health. Both also play roles in the regulation of your blood sugar level.1,2

When you get insufficient amounts of magnesium from your diet, your body will leach magnesium from your bones, muscles and internal organs, which can lead to osteoporosis, kidney problems and liver damage.

Vitamin B6 can help ameliorate this by escorting magnesium to the cells that need it most, thus ensuring that the magnesium you’re getting, whether from foods or supplements, is being used as efficiently as possible. In so doing, vitamin B6 also helps augment the many benefits of magnesium.

Magnesium-B6 combo is superior for severe stress

The importance of magnesium in combination with vitamin B6 was presented in a 2018 study3 in the journal PLOS ONE. Taken together, these two nutrients have been shown to have a complementary effect on stress reduction in animal studies.

In this randomized trial, they evaluated whether the combination of magnesium and B6 would improve perceived stress levels in 264 human subjects who also had low magnesium to start. Healthy adults with a depression anxiety stress scale score above 18 and a serum level of magnesium between 0.45 nanomoles per liter (mmol/L) and 0.85 mmol/L were randomized to receive either:

  1. 300 milligrams (mg) of magnesium in combination with 30 mg of vitamin B6
  2. 300 mg of magnesium only

The primary endpoint was a reduction in stress score from baseline to Week 8. While both treatment groups experienced similar reductions in their stress scores — the magnesium-B6 combo group reporting a 44.9% reduction in perceived stress and the magnesium-only group a 42.4% reduction — a more significant impact was shown in those with severe and/or extremely severe stress.

According to the authors, adults with a stress score at or above 25 had a 24% greater improvement with magnesium-vitamin B6 versus magnesium only at Week 8. Those taking magnesium and B6 in combination also experienced fewer side effects: 12.1% of those taking magnesium-vitamin B6 versus 17.4% of those taking magnesium only experienced some form of adverse event. As noted by the authors:4

“These findings suggest oral Mg supplementation alleviated stress in healthy adults with low magnesemia and the addition of vitamin B6 to Mg was not superior to Mg supplementation alone. With regard to subjects with severe/extremely severe stress, this study provides clinical support for greater benefit of Mg combined with vitamin B6.”

Magnesium and B6 may ease premenstrual syndrome

Magnesium and vitamin B6 are two nutrients commonly recommended for women struggling with premenstrual syndrome. According to a research paper5 published in the Journal of Caring Sciences, magnesium deficiency has been proposed “as one of the factors causing and intensifying premenstrual syndrome symptoms,” and magnesium appears to work because it has a calming effect on the neuromuscular system.

“Vitamin B6 is another proposed treatment for this syndrome,” the paper notes.6 “On the one hand vitamin B6 increases serotonin and dopamine levels and improves premenstrual syndrome symptoms, and on the other, it has an essential role in the synthesis of prostaglandin and fatty acids, which are reduced in etiologies causing premenstrual syndrome.

Moreover, researchers believe that vitamin B6 deficiency decreases dopamine in the kidneys and therefore increase sodium excretion, which in turn causes water accumulation in the body and induces symptoms such as swelling in extremities, edema, and abdominal and chest discomfort. The administration of vitamin B6 can thus decrease these symptoms and improve premenstrual acne.”

To evaluate the effects of these two nutrients on premenstrual syndrome, 126 women diagnosed with premenstrual syndrome, based on American Psychiatric Association criteria, were divided into three groups, which received either 250 mg of magnesium oxide, 250 mg of vitamin B6, or a placebo, taken from the first day of the menstrual cycle until the beginning of the next cycle.

Magnesium and B6 have similar rates of effectiveness

Overall, magnesium and B6 had similar rates of effectiveness for premenstrual syndrome in this Journal of Caring Sciences study. Mean scores of premenstrual syndrome before and after intervention in the three groups were as follows:

Magnesium Vitamin B6 Placebo

Before intervention: Before intervention

Magnesium : 36.89%

Vitamin B6 : 36.51%

Placebo : 35.8%

After intervention: After intervention

Magnesium : 22.22%

Vitamin B6 : 22.84%

Placebo : 28.41%

As you can see, while the placebo also helped reduce premenstrual syndrome symptoms, magnesium and B6 did so more effectively, and at similar rates. When looking at specific symptoms, B6 and magnesium were found to be the most effective for lowering rates of depression, water retention and anxiety. In conclusion, the authors noted:7

“Considering the importance of premenstrual syndrome and the numerous effects it has on society and the lives of women, health groups should prioritize the diagnosis and treatment of this syndrome. Since there is no definitive etiology and treatment for this syndrome, many researchers have tried to find the best and most effective drug with the least side effects to prevent the occurrence of the syndrome …

The current study was also undertaken with the goal of finding an effective compound with no side effects to reduce the symptoms of this syndrome and its direct and indirect economic and social effects. All compounds used in the current study had no side effects, were effective, non-chemical, and acceptable by most groups of women in the society.

Hence, health groups, especially midwives, can compare the effectiveness the compound on their specific patients and select the most appropriate treatment for each individual. Moreover, in cases where the patient is prohibited from using chemical drugs to treat premenstrual syndrome, such as oral contraceptive pills and gonadotropin releasing hormone (GnRH) agonists, the use of these compounds seems effective …”

Unfortunately, a combination of magnesium and B6 was not evaluated in this study. It would have been interesting to see what their combined effect would have been. Considering the importance of both of these nutrients for health, I see no risk in combining them, though, should you struggle with premenstrual syndrome.

The importance of magnesium for optimal health

Magnesium8 is the fourth most abundant mineral in your body and the second most common intracellular cation9 (positively charged ion) after potassium. It’s required for the healthy function of most cells in your body, but is especially important for your heart, kidneys and muscles.

Low magnesium will impede your cellular metabolic function and deteriorate mitochondrial function, which can have far-reaching health consequences, seeing how loss of mitochondrial function is a foundational factor in most chronic diseases, including heart disease and cancer.

According to one scientific review,10 which included studies dating as far back as 1937, low magnesium actually appears to be the greatest predictor of heart disease, and other recent research shows even subclinical magnesium deficiency can compromise your cardiovascular health.11

Being one of the most abundant minerals in the human body, it’s not surprising that it has several hundred biological functions. To list just a few, magnesium helps: 

  • Relax your muscles as well as your blood vessels — Being deficient in it can cause muscle cramps and weakness
  • Promote mental and physical relaxation — It’s a stress antidote that works by boosting GABA, an inhibitory neurotransmitter that relaxes your nervous system. Magnesium also helps boost your melatonin production
  • Detoxification and reduces damage from electromagnetic fields
  • Regulate blood sugar and improve insulin sensitivity, potentially protecting against Type 2 diabetes

Magnesium is required for activation of vitamin D

Magnesium is also a component necessary for the activation of vitamin D,12,13,14 and deficiency may hamper your ability to convert vitamin D from sun exposure and/or oral supplementation.

According to Mohammed Razzaque, professor of pathology at Lake Erie College of Osteopathic Medicine in Pennsylvania, coauthor of a study published in The Journal of the American Osteopathic Association (JAOA) in March 2018,15 “By consuming an optimal amount of magnesium, one may be able to lower the risks of vitamin D deficiency, and reduce the dependency on vitamin D supplements.”

Interestingly, the first paper I ever had published, back in 1985, was also in the JAOA. My paper was about the use of calcium to control hypertension, but if I had written the paper this century, it most certainly would have been about the use of magnesium for that purpose.16

A second study,17 published in The American Journal of Clinical Nutrition in December 2018 also concluded that your magnesium status plays an important role in your vitamin D status. Overall, people with high magnesium intake were less likely to have low vitamin D. They also had a lower mortality risk from cardiovascular disease and bowel cancer.

As explained by Dr. Qi Dai, professor of medicine at Vanderbilt University Medical Center and the lead author of this study, “Magnesium deficiency shuts down the vitamin D synthesis and metabolism pathway.” What’s more, magnesium was found to have a regulating effect, raising and lowering vitamin D based on baseline levels.

In people who had a baseline vitamin D level of 30 ng/mL (75 nmol/L) or below, magnesium supplementation raised their vitamin D level. However, in those who started out with higher vitamin D levels (50 ng/mL or 125 nmol/L), magnesium supplementation lowered their vitamin D.

Magnesium for brain health and neurological functioning

Magnesium is also crucial for optimal brain function, and is a common culprit in neurological ailments, including:

Migraines18,19,20 Researchers have noted that empiric treatment with a magnesium supplement is justified for all migraine sufferers.21

Depression — Magnesium plays an important role in depression as it acts as a catalyst for mood-regulating neurotransmitters like serotonin. Research22 published in 2015 found a significant association between very low magnesium intake and depression, especially in younger adults.

Research23 published in PLOS ONE demonstrated magnesium supplementation improved mild-to-moderate depression in adults, with beneficial effects occurring within two weeks of treatment. In fact, the effects of magnesium were comparable to prescription SSRIs in terms of effectiveness, but without any of the side effects associated with these drugs.

Participants in the treatment group received a daily dose of 248 milligrams (mg) of elemental magnesium for six weeks, while controls received no treatment. According to the authors, “It works quickly and is well tolerated without the need for close monitoring for toxicity.”

Memory problems and loss of brain plasticity — Memory impairment occurs when the connections (synapses) between brain cells diminish. While many factors can come into play, magnesium is an important one.

According to Dr. David Perlmutter, a neurologist and fellow of the American College of Nutrition, “magnesium is a critical player in the activation of nerve channels that are involved in synaptic plasticity.”24 Magnesium threonate, which most effectively permeates the blood-brain-barrier, is likely your best choice here.

The specific brain benefits of magnesium threonate were demonstrated in a 2010 study25 published in the journal Neuron, which found this form of magnesium enhanced “learning abilities, working memory, and short- and long-term memory in rats.”

Health benefits of vitamin B6

Like magnesium, vitamin B6 (as well as several other B vitamins) also plays an important role in heart and brain health. It is used in the creation of neurotransmitters, and is required for proper brain development during pregnancy and infancy.26

Vitamins B6, B9 (folate, or folic acid in its synthetic form) and B12 may be particularly important for supporting cognitive function as you age, and have been shown to play a major role in the development of dementia, including Alzheimer’s disease, which is the most serious and lethal form.

A primary mechanism of action here is the suppression of homocysteine,27 which tends to be elevated when you have brain degeneration. High homocysteine has also been implicated in the development of atherosclerosis.28,29

The good news is your body can eliminate homocysteine naturally, provided you’re getting enough B9 (folate), B6 and B12. One study confirming this was published in 2010.30 Participants received either a placebo or 800 micrograms (mcg) of folic acid (the synthetic form of B9), 500 mcg of B12 and 20 mg of B6.

The study was based on the presumption that by controlling homocysteine levels you might be able to reduce brain atrophy, thereby slowing the onset of Alzheimer’s. Indeed, after two years those who received the vitamin-B regimen had significantly less brain shrinkage compared to the placebo group.

A 2013 study31 took this research a step further, showing that not only do B vitamins slow brain shrinkage, but they specifically slow shrinkage in brain regions known to be most severely impacted by Alzheimer’s disease.

As in the previous study, participants taking high doses of folic acid and vitamins B6 and B12 lowered their blood levels of homocysteine, decreasing brain shrinkage by as much as 90%. High doses of vitamins B6, B8 (inositol) and B12 have also been shown to significantly reduce symptoms of schizophrenia, more so than standard drug treatments alone.32 Vitamin B6 is also important for healthy:

  • Metabolism, by helping break down amino acids in the muscles to be used as energy and by converting lactic acid to glucose in your liver
  • Immune system, as it helps create white blood cells that fight infections
  • Hair and skin health, by reducing hair loss and alleviating dermatitis

How to improve your magnesium and vitamin B6 status

The recommended dietary allowance (RDA) for magnesium ranges from 310 mg to 420 mg for adults over the age of 19, depending on age, gender and pregnancy status,33 and the adult RDA for vitamin B6 is between 1.2 mg and 2 mg per day, depending on age and gender.34

Both magnesium and vitamin B6 are abundant in whole foods. Good sources of magnesium include leafy greens, berries, avocado, seeds, nuts and raw cacao nibs. Eating a primarily processed food diet is the primary culprit in magnesium deficiency, and if you fall into this group, you’d be wise to take a magnesium supplement.

Vitamin B6 is abundant in animal foods such as beef and wild-caught salmon, as well as dark leafy greens, papaya, oranges, cantaloupe, sweet potatoes, avocados, bananas, spinach, pistachios and sunflower seeds.35 Nutritional yeast is another excellent source.

To learn more about the benefits of magnesium and/or vitamin B6, see “Reasons to Increase Your Magnesium Intake” and “Top Benefits of Vitamin B6.” In those articles, you’ll also find more details about top food sources for these nutrients, and how to identify a possible deficiency.

Julian Assange Writes A Letter To Supporters From British Prison, Here Is What He Said

(John Vibes) Julian Assange is seriously ill as he awaits extradition for charges that could land him in jail for the rest of his life. According to reports from the Swedish and Danish speaking press last week, Assange is currently being held in the hospital ward of “Belmarsh,” the UK’s most notorious prison. Belmarsh has been called “Britain’s Guantanamo Bay,” since prisoners accused of terrorism are typically sent there.

The post Julian Assange Writes A Letter To Supporters From British Prison, Here Is What He Said appeared on Stillness in the Storm.