Are Enzymes a Key to COVID Endothelial Injury?

Enzymes catalyze many biological reactions in your body. They regulate the rate of these chemical reactions, speeding them up so necessary functions like digestion, muscle contractions and other aspects of cellular metabolism can occur.1

Enzymes are also emerging as key players in COVID-19, as studies suggest damage to the endothelium, which are cells covering blood vessels, is contributing to the development of blood clots, or thrombosis, in the blood vessels of severely ill COVID-19 patients.2 Enzymes may turn out to be the missing link in helping to break up clusters of clotting proteins involved in this dangerous thrombosis.

Endothelium Damage Found in Critically Ill COVID-19 Cases

After noticing blackened fingers and toes — signs of what appeared to be microvascular thrombosis, or tiny blood clots in small blood vessels — in COVID-19 patients in advanced stages of the disease, physicians at the Yale School of Medicine began running clotting tests on their patients.3

Levels of Von Willebrand factor (VWF), a clotting protein released by endothelial cells, were found to be significantly elevated, which suggested to hematologist Alfred Lee that damaged endothelial cells may be releasing large quantities of VWF, leading to clots.4 This prompted the team to screen for additional markers of endothelial cell and platelet activation in critically and noncritically ill COVID-19 patients.

The study, which was conducted in April 2020, included 68 hospitalized patients with COVID-19 and 13 asymptomatic controls. VWF antigen was significantly elevated in COVID-19 patients admitted to the intensive care unit (ICU) compared to non-ICU COVID-19 patients,5 as was soluble platelet selectin (sP-selectin), which is sometimes used as a biomarker for infection and mortality.6

Specifically, mean VWF was 565% among ICU patients and 278% among non-ICU patients while soluble P-selectin was 15.9 ng/mL compared to 11.2 ng/mL.7 “Our findings show that endotheliopathy is present in COVID-19 and is likely to be associated with critical illness and death. Early identification of endotheliopathy and strategies to mitigate its progression might improve outcomes in COVID-19,” the researchers concluded.8

Likely not coincidentally, endothelial dysfunction is also associated with insulin resistance and plays a role in the vascular complications of diabetes,9 as well as being involved in obesity and high blood pressure,10 conditions that raise the risk of severe COVID19.

Even mild obesity may raise the risk of COVID-19 severity — COVID-19 patients with mild obesity had a 2.5 times greater risk of respiratory failure and a five times greater risk of being admitted to an ICU compared to nonobese patients. Those with a BMI of 35 and over were also 12 times more likely to die from COVID-19.11

Another study looking into the impact of coexisting health conditions like high blood pressure, heart disease and diabetes on COVID-19 outcomes found they’re linked to “poorer clinical outcomes,” such as admission to an intensive care unit, a need for invasive ventilation or death.12

It’s possible that the endothelial damage in all of these conditions plays a role in worsening COVID-19 outcomes, but it’s unclear which comes first — endothelial damage or COVID-19.

Endothelial Cells Are the ‘Main Target’ of SARS-CoV-2

Imperial College London cardiologist Thomas Lüscher told The Scientist that the endothelium is the main target of SARS-CoV-2, the virus that causes COVID-19.13 Under healthy conditions, blood cells can pass through the endothelium lining blood vessels, but when exposed to viral infections and other inflammatory agents, the endothelium becomes sticky and releases VWF.

The end result is a cascade of clotting and inflammation, both characteristics of severe COVID-19. According to a case report published April 8, 2020, “A hallmark of severe COVID-19 is coagulopathy, with 71.4% of patients who die of COVID-19 meeting … criteria for disseminated intravascular coagulation (DIC) while only 0.6% of patients who survive meet these criteria.”14

Writing in the European Heart Journal, Lüscher argues, “COVID-19, particularly in the later complicated stages, represents an endothelial disease,”15 which may help explain why multiple organ systems, including the lungs, heart, brain, kidney and vasculature, may be affected.

An additional study by Canadian researchers, published in Critical Care Explorations in September 2020, also revealed elevated VWF and soluble P-selectin levels in COVID-19 patients, along with higher glycocalyx-degradation products,16 a sign of damage to the glycocalyx, which envelops the endothelium.17 This can also be a sign of sepsis. Taken together, the research suggests that therapies targeting the endothelium may be useful for COVID-19, which is where enzymes come in.

Enzymes Used to Treat COVID-19

With the role of coagulopathy in severe COVID-19 becoming clearer, researchers have experimented with enzymes in the treatment of the disease. Fibrinolytic therapy, which uses drugs or enzymes to break up blood clots, has been used in a Phase 1 clinical trial that showed the treatment reduced mortality and led to improvements in oxygenation.18 Further, researchers wrote in the Journal of Thrombosis and Haemostasis:19

“There is evidence in both animals and humans that fibrinolytic therapy in acute lung injury and acute respiratory distress syndrome (ARDS) improves survival, which also points to fibrin deposition in the pulmonary microvasculature as a contributory cause of ARDS.

This would be expected to be seen in patients with ARDS and concomitant diagnoses of DIC on their laboratory values such as what is observed in more than 70% of those who die of COVID?19.”

The researchers reported three case studies of patients with severe COVID?19 respiratory failure who were treated with tissue plasminogen activator (TPA), a serine protease enzyme found on endothelial cells that’s involved in fibrinolysis, or the breakdown of blood clots.20

All three patients benefited from the treatment, with partial pressure of oxygen/FiO2 (P/F) ratios, a measure of lung function, improving from 38% to 100%.21 While it should be noted that several of the authors have patents pending related to both coagulation/fibrinolysis diagnostics and therapeutics, the results suggest such treatments deserve further evaluation in certain COVID-19 patients.

An evaluation of organ tissues from people who died from COVID-19 also revealed extensive lung damage, including clotting, and long-term persistence of virus cells in pneumocytes and endothelial cells.22

The findings indicate that virus-infected cells may persist for long periods inside the lungs, contributing to scar tissue. In an interview with Reuters, study co-author Mauro Giacca, a professor at King’s College London, described “really vast destruction of the architecture of the lungs,” with healthy tissue “almost completely substituted by scar tissue,”23 which could be responsible for cases of “long COVID,” in which symptoms persist for months.

“It could very well be envisaged that one of the reasons why there are cases of long COVID is because there is vast destruction of lung (tissue),” he told Reuters. “Even if someone recovers from COVID, the damage that is done could be massive.”24 Dissolving scar tissue is another area where enzymes, particularly proteolytic enzymes, may be useful.

Three Top Enzymes Act as Natural Anticoagulants

Holistic prophylactic alternatives that might be beneficial against blood clots include proteolytic enzymes such as lumbrokinase, serrapeptase and nattokinase, all of which act as natural anticoagulants by breaking down the fibrin that forms the blood clot. Fibrin is a clotting material that restricts blood flow, found both in your bloodstream and connective tissue such as your muscles. Fibrin accumulation is also responsible for scar tissue.

It is important to understand that when using these enzymes for fibrinolytic therapy they need to be taken on an empty stomach, at least one hour before or two hours after meals. Otherwise these enzymes will be wasted in the digestion of your food and will be unable to serve their fibrinolytic purpose.

As noted in Scientific Reports, some of the key mechanisms by which proteolytic enzymes exert their anticoagulant effect include “defibrinogenation, inhibition of platelet aggregation, and/or interference with components of the blood coagulation cascade.”25 Here’s a closer look at these important enzymes, all of which are available in supplement form or, in the case of nattokinase, via the food natto.

1. Lumbrokinase — This enzyme is about 300 times stronger than serrapeptase and nearly 30 times stronger than nattokinase,26 making it my strong personal preference and recommendation if you are using a fibrinolytic enzyme. Extracted from earthworms, lumbrokinase is a highly effective antithrombotic agent that reduces blood viscosity and platelet aggregation27 while also degrading fibrin, which is a key factor in clot formation.

2. Serrapeptase — Also known as serratiopeptidase, serrapeptase is produced in the gut of newborn Bombyx mori silkworms, allowing them to dissolve and escape from their cocoons. Research has shown it can help patients with chronic airway disease, lessening viscosity of sputum and reducing coughing.28 Serrapeptase also breaks down fibrin and helps dissolve dead or damaged tissue without harming healthy tissue.29

3. Nattokinase Produced by the bacteria Bacillus subtilis during the fermentation of soybeans to produce natto,30 nattokinase is a strong thrombolytic31 comparable to aspirin but without the serious side effects.32

It’s been shown to break down blood clots and reduce the risk of serious clotting33 by dissolving excess fibrin in your blood vessels,34 improving circulation and decreasing blood viscosity. Interestingly, in one in vitro study, the thrombolytic activity of equivalent amounts of nattokinase and TPA were found to be identical35 — TPA, remember, is the enzyme that led to improvement in the three COVID-19 case studies.36

Weekly Health Quiz: Vitamin D, Stress and Gratitude

1 Which of the following enhances vitamin D signaling and works synergistically with vitamin D to enhance your mitochondrial function?

  • Vitamin C
  • Quercetin
  • Glutathione
  • Melatonin

    Melatonin enhances vitamin D signaling and the two work synergistically to enhance your mitochondrial function. Learn more.

2 What is CommonPass?

  • A digital “health passport” initiative

    CommonPass is a digital “health passport” framework initiated by The Commons Project, the World Economic Forum and The Rockefeller Foundation. Learn more.

  • A drug industry-funded fact check group
  • A high-intensity Frisbee game
  • A technocratic term for those of privilege, to whom rules don’t apply

3 Looking at total mortality statistics, the COVID-19 pandemic has:

  • Doubled mortality in most countries
  • Not led to an excess of deaths compared to the last five years’ averages

    There are no excess deaths. The same number of people have died in 2020 that, on average, have died in previous years. This simply wouldn’t be the case if we had a lethal pandemic. Learn more.

  • Quadrupled mortality in a handful of countries, including the U.S.
  • Killed nearly half the population of India

4 Which of the following emotions has been shown to reduce stress and improve sleep, heart health and immune function?

  • Fear
  • Surprise
  • Gratitude

    Gratitude has been shown to reduce stress and improve sleep, heart health and immune function. Enhancing your well-being can be as simple as taking some time each day to reflect on what you’re thankful for. Learn more.

  • Acceptance

5 Opioids control moderate to severe pain:

  • Two to four times better than over-the-counter pain relievers
  • About 50% less effectively than over-the-counter pain relievers
  • No study has ever assessed opioids for moderate to severe pain
  • No better than over-the-counter pain relievers

    Research shows opioids do not control moderate to severe pain any better than over-the-counter drugs such as acetaminophen, ibuprofen and naproxen. Learn more.

6 Which of the following has a healthy success record when used for conditions such as chronic pain, autoimmune diseases and opioid dependence?

  • Low-dose naltrexone (LDN)

    Low-dose naltrexone, an opiate antagonist, can benefit most autoimmune and chronic pain conditions. When microdosed, LDN has also been shown to help long-term users of opioids wean off their medication. Learn more.

  • Melatonin
  • Omega-3
  • Opioids

This Spice Might Extend Your Life

Researchers from Cleveland Clinic in Ohio reviewed health records of more than 570,000 people from four large studies and found, as compared to those who rarely or never ate chili peppers, that those who ate them on a regular basis reduced their risk of death from heart-related sources by 26%, from cancer by 23% and from all-cause mortality by 25%.1

This reduction in the potential risk of death is significant and could make an impact on the number of people with heart disease and cancer. An American Heart Association report released in January 2019 found 48%, or 121.5 million, adults in America had cardiovascular disease.2

The 2020 statistical update showed cardiovascular disease continues to be the No. 1 cause of death, accounting for 859,125 deaths in 2017 and claiming more lives every year than chronic lower respiratory disease and all forms of cancer combined.3

According to the National Cancer Institute, there will be an estimated 1.8 million people diagnosed with cancer in the U.S. and an estimated 606,520 people will die in 2020.4 The sheer number of people who may experience an impact on their longevity by making simple changes to their nutritional intake is overwhelming.

While chili peppers are not the answer for everyone, it is important to note that scientific evidence continues to mount supporting the hypothesis that you can take control of your health by making consistent changes in your lifestyle choices.

Chili Peppers May Extend Your Life

You may find chili peppers in your favorite Tex-Mex foods or Indian curry. Preliminary data presented at the American Heart Association virtual conference titled “Scientific Sessions 2020”5 suggest that those who regularly eat chili peppers could have a longer life.6

The researchers hypothesize this is a result of the antioxidant, anti-inflammatory, anticancer and blood glucose mediating properties known to be present in chili peppers. Each of these factors may play a role in reducing the risk of cardiovascular disease or cancer.

To reach this determination, the team analyzed 4,729 studies and included four large studies with health outcomes from China, the U.S., Iran and Italy. They were surprised that past published studies demonstrated that regularly eating chili peppers could reduce the overall risk of all-cause mortality.

Senior author Dr. Bo Xu commented, “It highlights that dietary factors may play an important role in overall health.”7 Xu, a cardiologist at Cleveland Clinic, went on to say in a press release:8

“We were surprised to find that in these previously published studies, regular consumption of chili pepper was associated with an overall risk-reduction of all-cause, CVD (cardiovascular disease) and cancer mortality. The exact reasons and mechanisms that might explain our findings, though, are currently unknown.

Therefore, it is impossible to conclusively say that eating more chili pepper can prolong life and reduce deaths, especially from cardiovascular factors or cancer. More research, especially evidence from randomized controlled studies, is needed to confirm these preliminary findings.”

Xu cautioned there were several limitations, including that the four studies only had limited information on health data and confounding factors that may have influenced the results. He also noted the amounts and types of chili pepper the participants ate during the studies were also different.9 The researchers are continuing to analyze the data and plan to publish the literature review.10

What’s the Secret Ingredient?

Capsaicin is the bioactive compound in chili peppers responsible for the hot and spicy kick,11 and the likely compound researchers named as a potential explanation for the benefits they found.12

Chili pepper is a fruit pod belonging to the nightshade (Solanaceae) family. Other members of the Solanaceae family include tomato, potato, eggplant, cayenne pepper and paprika.13 The plant is a perennial shrub that grows up to 1 meter (3.2 feet) in height and is native to Central America.14

Capsaicin is concentrated in the seeds and the inner white membrane found when you cut the pod open. The plant produces capsaicin as a protection against fungal attack.15 Peppers with more capsaicin are spicier and hotter. While it’s colorless and odorless, it tricks your brain into perceiving heat where it touches your body.

This burning sensation is what you experience when you eat the peppers, as it is not a taste. Instead, the compound stimulates nerves that send two messages to the brain of warmth and intense stimulation. The burning sensation is a combination of these two messages.16

Although the benefits of foods that contain capsaicin are plentiful, as I discuss below, eating chili peppers is not a cure-all and some people cannot tolerate the compound or the flavor. As with many other things, too much of a good thing is not always a better thing. Eating too much capsaicin can trigger nausea and vomiting, diarrhea and a burning sensation in your gastrointestinal tract.17

The Capsaicin Connection

Many of the health benefits from chili peppers come from the compound capsaicin. There are hundreds of varieties of peppers that come in different shapes, sizes, colors and degrees of hotness. How the heat is measured is based on the work of Wilbur Scoville in 1912. He developed a test to measure chili peppers’ pungency and heat that is now called Scoville heat units.18

Different factors can affect the perception of heat and the units are used to measure anything that’s made from chili peppers. Scoville’s first tests depended on a panel of taste testers and the units were based on how dilute the pepper mixture must be before it lost the sensation of heat.

The test now uses high-performance liquid chromatography and measures the concentration of capsaicin in the product. The scale ranges from zero to 2.2 million. For example, the common bell pepper has zero Scoville heat units (SHU). Popular banana peppers range from zero to 500 SHU and Anaheim peppers can go as high as 2,500 SHU. Jalapeno peppers range from 2,500 to 8,000 SHU and serrano peppers top out at 23,000 SHU.

If you’re looking for more heat, Komodo dragon peppers range from 1.4 million to 2.2 million SHU and the supreme hot chili pepper, the Carolina Reaper, is measured at 2.2 million plus SHU. When scientists measure pure capsaicin, they find it contains 16 million SHU.

Capsaicin is the active ingredient used in self-defense pepper spray. The spray burns the skin on contact and has an SHU ranging from 2 million to 5.3 million, depending upon the brand. Yet, it’s this same compound chili makers use to create their spicy concoctions that has health benefits for those who partake regularly.

In the 1980s Paul Rozin, professor of psychology at the University of Pennsylvania, studied chili and the people who ate it, describing a form of “benign masochism.”19 The term was used to describe how some people enjoy negative emotions when there is no real threat to their safety, like riding a roller coaster or watching a scary movie.

Later, another team of researchers from Penn State set out to discover if there were personality traits that drew some people to love spicy foods and found those who liked the burn weren’t as sensitive to the heat.20

“They don’t rate it as intense. And again we’re not sure if that means that biologically they’re not getting as much of a response, or if they’re desensitized, or if they are the type of person who went skydiving the day before, so the burn of capsaicin in relation to the rush of adrenalin doesn’t rate that high.

We expected the sensation-seekers to rate spicy meals higher, for example, and they did. But there was variation in their responses depending on the type of spicy meal. Some people like Asian cooking — which may include capsaicin but has other chemesthetic ingredients, too, like ginger and Wasabi — yet they don’t like chili barbecue. Why do they like one type of spicy and not another?”

Adding Ginger Boosts Anticancer Activity

Capsaicin has been studied extensively and it may surprise you how many health benefits have been associated with the compound. For instance, capsaicin may help promote long-term heart health. In one animal study involving rodents with high blood pressure, the animals experienced relief after eating food mixed with capsaicin.21

The researchers suggested the compound activated the transient receptor potential vanilloid 1 (TRPV1), which contributes to vasorelaxation and lowered blood pressure. Capsaicin may also help promote healthy functioning of the digestive tract.

In one study researchers suggested capsaicin could be a gastroprotective agent in those with Helicobacter pylori mucosal damage or who use nonsteroidal anti-inflammatory drugs (NSAIDs).22 Capsaicin may participate in the fight against cancer by attacking cancer cell growth.23

The results of one study presented at the 2019 Experimental Biology meeting in Orlando, Florida, showed capsaicin could reduce metastasis in lung adenocarcinoma, which is the majority of all non-small cell lung cancers.24

While it can act on its own, in combination with 6-gingerol, a compound found in raw ginger root, evidence shows it has greater potential. In one animal study using mice prone to lung cancer, researchers found that when fed a combination of capsaicin and 6-gingerol, they had a reduced risk of lung cancer.25

While under observation, all the mice that received capsaicin developed lung tumors; half the mice that received 6-gingerol developed lung tumors, but only 20% of the mice given the combination developed cancer.

Capsaicin Plays a Role in Pain Relief and Weight Loss

Capsaicin plays a role in pain relief, in part by depleting your body’s supply of substance P. This is a chemical component of nerve cells involved in transmitting pain signals to your brain. Capsaicin also works by desensitizing sensory receptors in your skin.26

That’s why capsaicin is used in topical creams and patches, which deliver an intense burning sensation that ultimately relieves pain. In one case study, scientists acknowledged that capsaicin was most often analyzed for relieving postherpetic neuralgia after shingles and in HIV-associated neuropathy.27

In an effort to determine if it had efficacy in other forms of neuropathic pain, capsaicin was used in a man who had persistent wound pain after a bomb explosion. He experienced an 80% reduction in symptoms after using a capsaicin patch.

The compound also may play a role in weight loss when added to your diet. In a study published in the Journal of Nutritional Science and Vitaminology, participants were given 10 grams of red pepper during a meal.28

After eating, the researchers monitored the participants’ energy expenditure and learned that chili peppers increased carbohydrate oxidation for as much as 150 minutes after the meal. Scientists found your body can burn an extra 50 calories per day when you consume capsaicin regularly and:29

“… would produce clinically significant levels of weight loss in 1-2 years. While capsaicinoids are not a magic bullet for weight loss, the evidence is that they could play a beneficial role, as part of a weight management program.”

Several studies have demonstrated that capsaicin may help reduce hunger as well.30,31 According to a study published in the European Journal of Nutrition, including capsaicin during the meal had no effect on satiety but did reduce the production of ghrelin, the hormone responsible for triggering hunger, within 15 minutes after the meal.32

In another study, after 12 weeks of supplementation, participants were found to eat less and had a reduction in their waist-to-hip ratio.33 While not a magic bullet, chili peppers may be one weapon you can add to your arsenal of healthy food and lifestyle choices that help you take control of your health.

Lunar Eclipse In Gemini: Applying Ourselves In An Adaptable Way

We are having a Full Moon Lunar Eclipse in Gemini on November 30th which is peaking at 9:30am Universal Time. This will be on the night of November 29th to the morning of the 30th for the Americas. It will be a penumbral eclipse which only has a slight shade on the Moon dimming it’s brightness. These ones are harder to notice and can be mistaken for a regular Full Moon. It will be visible (weather permitting) wherever it will be nighttime in part or all of its duration. This includes all of the Americas, most of Asia, some parts of Europe, and Australia.

This is the first of two eclipses occurring back to back, with this one followed by a more powerful Total Solar Eclipse in Sagittarius on December 14th/15th. This is also the first one in Gemini and the second of a series of Eclipses occurring in the Gemini-Sagittarius axis which we will be experiencing until late 2021. (You can join my mailing list here to receive my future eclipse articles and other content.)

Eclipses reflect evolutionary changes in specific areas of our lives which can play out over the following 6 months and can begin up to 6 weeks prior. However, they are also part of a 1.5-2 year process in which the Lunar Nodes and most Eclipses are in the same signs. The changes that occur are connected to the sign they are in, the planets they are configured to, and how this all lines up with our individual astrological blueprints (natal chart).

Lunar Eclipse In Gemini

This eclipse puts an emphasis on Gemini themes as it is near the Lunar North Node. This indicates changes associated with this sign that can have an increasing effect in how its energies are expressed in a way that serves your evolution. However, it can also be a culmination or release of old ways of expressing it as well. Ultimately it is about working with Gemini themes and areas of life in new ways. Certain developments, along with issues and challenges, connected to this sign can come up to help in this process.

Gemini is an Air sign which has social and intellectual properties. Ruled by Mercury, it is associated with the mind, communication, information, words, writing, facts, curiosity, and commuting. Gemini energy is adaptable, dualistic, agile, versatile, and quick witted yet can also be restless, scattered, duplicitous, overly talkative, and superficial.

Gemini correlates with our local/immediate environment, neighbourhood, siblings/cousins, communication devices/computers, and vehicles. It is associated with the arms, hands, shoulders, and nervous system. Considering that Gemini is a Mercurial sign, we can experience some similar complications as Mercury retrograde near these eclipse periods and in between other Gemini eclipses.

This Full Moon eclipse opposes the Sun in Sagittarius which is near the Lunar South Node. Over the next year and a half, we are also needing to address or move beyond Sagittarius expressions that can be holding us back from our evolution. This can play out more so with negative aspects of this sign such as strong opinions, judgements, dogmas, having blindspots, or unrealistic idealism. This eclipse can reflect these Sagittarius themes being at odds with the Gemini focal point mentioned in earlier paragraphs.

Lunar Eclipse Applying A Sextile To Mars Which Is In Post Retrograde Shadow

Mars ended its retrograde on November 13th/14th and has been picking up speed in forward position since. Some of the themes that have come up since mid-summer, and especially this past fall, are experiencing a conclusion process from now until early January.

Some of the shifts associated with the Gemini themes of this eclipse, now and over the coming months, can impact how we assert ourselves in a supportive way. In November and surrounding months, there is a recalibration when it comes to how we apply our drive, physical energy, sexuality, fighting nature, identity, individual needs, anger, or aggression. The changes, issues, developments, or complications reflected by the eclipse is connected to this process and how we should move forward.

Lunar Eclipse Quincunx Venus Which Is Opposing Uranus

The Moon is applying towards a quincunx aspect with Venus in Scorpio during this eclipse. There can be challenges, frustrations, and complications between the Gemini energies/themes of this eclipse (mentioned previously) and Venus ruled areas of love, relationships, friends, values, pleasures, indulgence, money, things pertaining to aesthetics, and/or perhaps linked to Scorpio matters such as shared/others resources, sexuality, debt/credit, jealousy, power/control issues, shadows, or hidden matters.

In some cases an action or development in one of these ways/areas can create problems or issues for another which may require adaptability and some sort of resolution. Venus is also in an opposition with Uranus which can reflect instability, rebellion, surprises, inconsistencies, uncertainties, separations, and sudden changes likely around Venus ruled areas mentioned above but can play out in other disruptive ways as well.

Lunar Eclipse Square Stationary Neptune

At around thirty three hours prior to this eclipse, Neptune in Pisces ended its retrograde as it is now slowly beginning to move forward and gradually picking up speed over the coming weeks. This retrograde began in the second half of June, therefore at this time and in surrounding weeks, you may experience something concluding, shifting, or page turning in connection to certain things that happened then.

It can be connected to Neptune themes such as spirituality/mysticism, creativity, music, visual media, compassion, sacrifice, fantasies, illusions, lack of boundaries, dreams, escapism, addictions, illness, some sort of deception, or not seeing something clearly. However, even if you don’t see a connection between then and now, these Neptune themes and energies can be stronger at this time regardless.

Neptune is in a wide t-square with the Sun and Moon at the time of this eclipse which can carry some of these themes (mentioned in above paragraph) and transitioning Neptunian energy into the coming months. However, it is a hard aspect which can also bring a sense of scatteredness, confusion, anxiety, and lack of focus.

Issues with water can occur for some people or perhaps parts of the world. The situation around the pandemic and the public perception of it is very Neptunian (deception, illusion, confusion, illness) and we can obviously expect more issues and conflicts around opinions/beliefs (Sagittarius) and information (Gemini) to play out.

Mercury Sextile Saturn and Jupiter In Capricorn

Mercury, the ruler of Gemini and this eclipse, is in Scorpio while separating from a tight sextile with Jupiter and applying one towards Saturn which are both in late Capricorn and on their way towards Aquarius. Generally speaking, this is supportive for making long term constructive plans and building towards something that will be initiated or changing from something else.

This can be especially so for career or ambition related things, but ultimately the way this plays out also depends on what’s going on your personal natal chart and astrological blueprint. It can also be good for putting into place some sort of structure and/or perhaps a consolidation. Applying our minds towards practical matters and responsibilities can also be a manifestation of this configuration.

Things To Consider

What has come up for you in recent weeks that is reflective of some of the themes mentioned in this article? Is there something that should be addressed or changed when it comes to areas pertaining to communication or information? Do you need to be more versatile or adaptable? What are the new or adjusted ways in which you need to be applying yourself? What changes do you need to make to fulfill your long term goals? What do you need to let go of or shake up when it comes to your relations, values, love, pleasures, or finances?

These are just some examples of what can be playing out for you but not limited to these either. Keep in mind that the themes of this specific eclipse will play out until Spring. It is best to try to tune into this energy as it happens and pay attention to your feelings to help you in decisions you need to make in the future.

The two weeks following this eclipse can be a good time to initiate any sort of releasing process if you feel necessary. The eclipse begins at 7:32am Universal Time on November 30th with it peaking at 9:42/43am and finishing at 11:53am. The Moon begins to wane after 9:30am GMT. You can click here to see when the peak will be in your time zone.

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