NAD+ Helps Restore Age-Related Muscle Deterioration

The tendency is to lose muscle as you age, a condition known as sarcopenia. If you don’t do anything to stop it you can expect to lose about 15% of your muscle mass between your 30s and your 80s.1 An estimated 10% to 25% of seniors under the age of 70 have sarcopenia and as many as half those over the age of 80 are impaired with it.2

Enforced bedrest, due to hospitalization, for example, can also have a dramatic impact on your muscle mass, even if you’re younger. According to a 2015 review3 in Extreme Physiology & Medicine, you can lose 5.2% of your muscle mass in the first two weeks of bedrest. By Day 23, you can have lost up to 10% of your quadriceps muscle mass.

Not only are strong muscles a requirement for mobility, balance and the ability to live independently, but having reserve muscle mass will also increase your chances of survival4 when sick or hospitalized. Since muscle is lost far more easily and quicker than it’s built, finding ways to continuously promote and maintain your muscle mass is of utmost importance.

The Crucial Role of NAD+

As reported by Science Daily,5 scientists recently discovered that Alzheimer’s-like protein aggregates underlie the muscle deterioration commonly seen in aging, and that nicotinamide adenine dinucleotide (NAD+) is essential for combating this condition.

Their study,6 published in the journal Cell Reports, showed that protein aggregates (amyloid) could be blocked by boosting the levels of NAD+, a biomolecule that is also essential for maintaining mitochondrial function.

Higher levels of NAD+ were found to turn on the defense systems of the mitochondria and restore muscle function. Aggregated proteins have long been thought to be a contributor to brain aging, and this study proves aggregated proteins also contribute to muscle aging.

“The most prominent component of these protein aggregates is beta-amyloid, just like in the amyloid plaques in the brains of patients with Alzheimer’s disease,” said Johan Auwerx at EPFL’s School of Life Sciences. “These abnormal proteotoxic aggregates could serve as novel biomarkers for the aging process, beyond the brain and muscle.”

The study points out that NAD+ homeostasis is required to maintain proteostasis, i.e., the regulation of protein creation, folding, trafficking and degradation. It turns out that boosting NAD+ in later life will reduce amyloidosis (the buildup of amyloid) and mitochondrial dysfunction.

The importance of NAD+ for healthy muscle function is also reviewed in “Sarcopenia and Muscle Aging: A Brief Overview,”7 published in the journal Endocrinology and Metabolism. The paper highlights:

“… recent findings that describe key pathophysiological phenotypes of this condition, including alterations in muscle fiber types, mitochondrial function, nicotinamide adenine dinucleotide (NAD+) metabolism, myokines, and gut microbiota, in aged muscle compared to young muscle or healthy aged muscle.”

As indicated by the Cell Report study, this Endocrinology and Metabolism paper highlights the connection between sarcopenia and mitochondrial dysfunction in both skeletal muscle and motor neurons.

People with sarcopenia have been found to have both reduced mitochondrial oxidative capacity and inhibited NAD+ biosynthesis, and several studies have proposed that mitochondrial dysfunction in your neurons actually drive the development of sarcopenia.8

What Is NAD+?

NAD+ is a substrate for a number of important enzymes, including poly(ADP-ribose) polymerase (PARP) and sirtuin 1 (SIRT1), which is known as a classic longevity protein. NAD+ is also essential in metabolic processes such as creating ATP in your mitochondria. It accepts and donates electrons and is used in oxidation-reduction reactions in the mitochondrial electron transport chain.

Interestingly, what scientists have observed is that NAD+ levels decline in most tissues over time, and is associated with aging in general and is therefore thought to play an important role in many age-related diseases.

According to the Endocrinology and Metabolism paper,9 researchers have shown that when the NAD+ salvage pathways in muscle are impaired, mitochondrial dysfunction and decreased muscle mass ensues.

NAD+ boosting molecules such as nicotinamide riboside (NR), nicotinamide mononucleotide (NMN), nicotinamide (a form of vitamin B3 or niacin) and nicotinic acid (niacin) have all been shown to protect against age-related muscle disease.

How to Boost NAD+

Of those four, NMN is my personal favorite as it activates the NAD+ salvage pathway. As explained by Siim Land in a recent interview, featured in “Simple Strategies That Will Improve Your Immunity,” which also reviews the importance of NAD+ in COVID-19:

“A lot of the NAD that your body produces is recycled through the salvage pathway. Very little (less than 1%) of it is going to come from food, especially tryptophan or niacin. The easiest way to prevent losing your NAD as you get older or as you get immunocompromised is to promote the salvage pathway.”

I’ve previously recommended the use of NR over NMN but have since changed my stance. NR used to be considered superior because no NMN transporter — required to get it into cells — had been detected. We now know there is such a transporter, which gives NMN the advantage as it’s also a more direct NAD+ precursor.

NAD salvage pathway

Most of the NAD+ precursor research is done with NR and that used to be my primary choice. However, as you can see from the image above, NMN converts to NAD+ whereas NR must first be converted into NMN before it can be converted into NAD+,10 so it makes more sense to use NMN for NAD+ augmentation.

The image above also shows how niacin (NA) also finds its way to become NAD+. Niacin is also a useful supplement to use in increasing NAD+ levels. You just need to limit the dose to about 25 mg, which will likely prevent any flushing. Higher doses are not likely as effective as NMN and exercise in producing NAD+.

The NMN transporter was discovered11,12 shortly before my interview with David Sinclair, Ph.D., a professor of genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. Interestingly, NMN is also Sinclair’s favorite NAD+ precursor.

Sinclair is generally acknowledged for bringing the importance of NAD+ to the world with his experiments at MIT in the late ‘90s which connected NAD+ to sirtuin activation. We discuss these issues in “The Revolutionary Science of Aging and Longevity,” the interview from which is embedded above for your convenience.

I believe one of the most effective ways of boosting your NAD+ level is to use NMN in suppository form, as this allows you to avoid most of the methylation of the supplement. Other alternatives include subcutaneous or intranasal administration, all of which are more effective than oral supplements.

Unfortunately, NMN is not sold in suppository form, so you would need to get silicone candy molds and use coconut oil to serve as binder for the NMN. The suppositories would need to be refrigerated as coconut oil tends to melt at 75 degrees Fahrenheit. Additionally, NMN is quite perishable, which is another reason to refrigerate it.  

As for the other NAD+ boosters, I do not recommend using high-dose niacinamide because in high doses it inhibits Sirt1, an important longevity protein. As mentioned above, low-dose niacin (vitamin B3) of 25 mg can be used.

Low doses of niacin, along with NMN in suppository form — both of which are precursors to NAD+ — are typically sufficient. As an added boon, raising your NAD+ also appears protective against severe COVID-19, as detailed in “Is Niacin a Missing Piece of the COVID Puzzle?” There are also NAD+ supplements available, but their price tags can be prohibitive.

Lifestyle Strategies Can Address Underlying Cause of Low NAD+

While supplements such as NMN can certainly be helpful, if your NAD is low, your best bet is really to address the underlying cause. The good news is that this can be done through simple lifestyle strategies such as exercise, sauna bathing, fasting, realigning your circadian rhythm and minimizing electromagnetic field (EMF) exposure.

One of the reasons exercise, heat exposure and fasting work to address low NAD+ levels is because they are catabolic stressors that activate AMP protein kinase (AMPK). AMPK, in turn, activates an enzyme called NAMPT, which governs the NAD+ salvage pathway.

Blood flow restriction (BFR) training can be particularly beneficial in terms of exercise. It has been shown to naturally increase your NAD level and is very safe for the elderly. You can learn more about this in “BFR Training for Muscle Mass Maintenance.”

Your circadian rhythm, meanwhile, plays a role because it is controlled by longevity genes called sirtuins, SIRT1 in particular. If your circadian rhythm is misaligned, then sirtuins are not expressed, which in turn inhibits NAMPT, thereby shutting down your NAD+ salvage pathway.

Oxidative stress and inflammation also use up and deplete NAD+, and exercise, sauna and fasting all help to reduce these. As a result, less NAD+ is depleted. So, these strategies not only improve your NAD+ production, but also reduce your body’s NAD+ consumption. The end result is a higher NAD+ baseline.

EMF exposure, which is the topic of my book “EMF*D,” is one common source of oxidative stress, so it too increases your NAD+ consumption. It does this by activating PARP, a DNA repairing enzyme. Each time PARP is activated, it uses up 150 molecules of NAD+. Hence, reducing your EMF exposure can also be an important strategy to preserve and protect your NAD+ level.

Your body also uses up NAD+ to detoxify alcohol, so if nightly drinking is part of your routine, consider giving it up. To learn more about how healthy lifestyle strategies such as the ones mentioned here can improve your NAD+ level, consider reading through the paper “Healthy Lifestyle Recommendations: Do the Beneficial Effects Originate from NAD+ Amount at the Cellular Level?”13

NAD+ Is a Crucial Antiaging Component

So, to summarize, raising your NAD+ level and keeping it high has many important health benefits, from supporting mitochondrial function, which is crucial for general health and longevity, to protecting against severe COVID-19 and age-related muscle loss.

The great news is that this can easily be done by implementing the healthy lifestyle strategies reviewed above — exercise, sauna, fasting and recalibrating your circadian rhythm — while simultaneously avoiding things that deplete your body of NAD+, such as EMF exposure and excessive alcohol consumption. On top of that, supplements such as NMN together with normal doses of niacin can help boost your NAD+ in the short term.

Thyme Extract Helps Treat COVID-19

Venezuelan President Nicolas Maduro made the news when he began promoting Carvativir, an oral solution made from extracts of thyme and oregano, for the treatment of COVID-19.1 Long before placebo-controlled, randomized studies were the gold standard for clinical trials, people relied on results from small groups of people.

If a traditional medicine had positive results in a community, it was used. Without statistical analysis or comparing p-values, people had to rely on the proximate results. This meant a traditional medicine that was only nominally better than doing nothing may not have been adopted by indigenous people as the effects would not have been as obvious.

Through testing and experimentation, this served communities well in treating infections and other health conditions where treatment success could be measured quickly, such as using ginger for an upset stomach. One such traditional medicine is wild thyme (Thymus serpyllum), long used in the treatment of respiratory and digestive issues.2

Many of the benefits of thyme are from the essential oils made from Thymus vulgaris,3 which include potent compounds like thymol, camphene, linalool, and carvacrol. Thymol is the most active constituent of thyme essential oil. Levels can vary depending on the climate, extraction method and production practice, ranging from 3% to 80%.4

While thyme has a long history in traditional medicine, more recent scientific analysis and clinical studies have demonstrated another powerful effect the essential oil has on health.

Venezuela Reports Encouraging Results Using Carvativir

Reuters wrote that Maduro “is promoting a “miracle” medication derived from thyme called Carvativir that he said neutralizes COVID-19 with no side effects, although some doctors say it is not backed by science.”5 According to the report, Maduro said the solution was tested on people who were being treated at emergency medical facilities and at a Caracas hospital.

During a televised broadcast, he claimed Carvativir had been through nine months of study and clinical application on people who had been “very sick” and “intubated,” yet had subsequently recovered.

In another statement, Venezuela’s National Academy of Medicine confirmed the solution has therapeutic potential against coronavirus, but cautions it may be prudent to “wait for more data from the Carvativir tests … to consider it a candidate for an anti-COVID-19 medication.”6

While doctors have also acknowledged that thyme essential oils have been used for centuries on infections but have not been established against COVID-19, Venezuelan scientists, including Hector Rangel, a virologist who led studies on COVID-19 vaccines, assured the media that Carvativir has demonstrated activity against cells infected with SARS-CoV-2 in vitro.7

Maduro has promised studies will be published demonstrating Carvativir’s effectiveness. Due to the “tremendous controversy” generated over his initial comments, he now calls the medication “complementary” in the treatment against COVID-19.8

Headlines and Media Outlets May Not Tell the Whole Story

It becomes difficult to isolate evidence and data when headlines and articles are not impartial, such as “A Traditional Herb Created By Catholic Holy Doctors Criticized By World Health Experts”9 and “Doctors Skeptical As Venezuela’s Maduro Touts Coronavirus ‘Miracle’ Drug.”10 Instead of preparing arguments based on data, the media appear to be crafting their own narrative.

This has recent historical precedent when the fight over using hydroxychloroquine in the treatment of COVID-19 was highly politicized and covered by the media, in a role that can be likened to genocide.

It’s impossible to estimate how many lives may have been saved had journalists done their due diligence and reported on the science truthfully as opposed to taking their lead from businesses that spend the most on advertising, namely drug companies.

Carvativir may or may not be effective or complementary in the treatment of COVID-19, yet before the data can be released, the drug is labeled as quackery. As most in the holistic field have been aware, there is an undercurrent of censorship used to mislead people that ultimately lines the pockets of the pharmaceutical industry.

During the COVID-19 pandemic, many conventional doctors have also gotten a taste of what it’s like to have potentially life-saving treatments censored. July 23, 2020,11 Dr. Harvey A. Risch, professor of epidemiology at Yale School of Public Health, published an op-ed in Newsweek in which he expressed his dismay and frustration on this topic as it pertains to hydroxychloroquine.12

“I have authored over 300 peer-reviewed publications and currently hold senior positions on the editorial boards of several leading journals.

I am usually accustomed to advocating for positions within the mainstream of medicine, so have been flummoxed to find that, in the midst of a crisis, I am fighting for a treatment that the data fully support but which, for reasons having nothing to do with a correct understanding of the science, has been pushed to the sidelines.

As a result, tens of thousands of patients with COVID-19 are dying unnecessarily … I am referring, of course, to the medication hydroxychloroquine.

When this inexpensive oral medication is given very early in the course of illness, before the virus has had time to multiply beyond control, it has shown to be highly effective, especially when given in combination with the antibiotics azithromycin or doxycycline and the nutritional supplement zinc.

Physicians who have been using these medications in the face of widespread skepticism have been truly heroic. They have done what the science shows is best for their patients, often at great personal risk.

I myself know of two doctors who have saved the lives of hundreds of patients with these medications but are now fighting state medical boards to save their licenses and reputations. The cases against them are completely without scientific merit.”

Thyme Has Demonstrated Antiviral Activity

The Venezuelan Minister for Science and Technology, Gabriela Jiménez, confirmed that the active ingredient in Carvativir is isothymol isolated from oregano and thyme.13 While the essential oils from thyme have not been scientifically proven against COVID-19, there is scientific evidence they have antiviral and antibacterial properties.

Historically, thyme has been used to help control cough associated with upper respiratory infection. One tested combination14 used with upper respiratory infections is thyme and primrose in combination with thymol, which was shown to alleviate cough and shortness of breath and to shorten the length of the infection.

Evidence has also shown thyme is active against herpes15 and other viruses, likely by interfering with the protein envelope that surrounds virulent viruses, such as SARS-CoV-2. One study16 published in 2017 showed thymol was highly selective and a promising candidate against herpes infections.

Research from the University of Ahvaz17 showed extracts from thyme provided protection against the Newcastle virus that causes illness and death in birds and is transmissible to humans. Another analysis18 showed essential oil from Thymus transcaspicus, a variety of thyme, had moderate antimicrobial and antiviral activity.

Thyme has also been evaluated against the influenza virus as antiviral resistant strains continue to emerge. Essential oils have been tested in experimental conditions, but one study19 tested essential oils from eucalyptus, Citrus bergamia and Thymus vulgaris in vapor form.

Vaporized essential oils from thyme, among others, displayed 100% inhibitory activity without adverse effects on the epithelial layers, suggesting they could be “potentially useful in influenza therapy.”20

Officials Push Vaccine Over Prevention and Treatment

Carvativir is not the first cost-effective potential treatment to be ridiculed in the media in favor of sitting and waiting until an unproven genetic experiment can be unleashed on the public under the guise of Operation Warp Speed and a COVID-19 vaccine.

While the results on Carvativir are not yet published as of this writing, there are other effective and long-standing preventive measures and treatments for this virus. Although the recently released shot is being called a vaccine, by medical definition it’s more accurately an experimental gene therapy that could prematurely kill many people.

As I discussed in “How COVID ‘Vaccines’ May Destroy the Lives of Millions,” the way in which the messenger RNA (mRNA) vaccines are produced may increase the risk of anaphylaxis. Additionally, free mRNA can fuel chronic, long-term inflammatory diseases.

As I also wrote in the article linked above, equally shocking are the personal videos sharing the severe side effects people are experiencing — videos which are quickly removed by social media platforms, ostensibly for violating some term of service. It’s hard to fathom how a personal experience can be considered “false information.”

Whether you choose to take the vaccine or not, it is important to remember that it does not stop you from getting COVID-19 and may not be effective against the virus as it naturally mutates in the environment. It is essential you take steps to protect your overall health and be aware of the strategies you can use to prevent infection and be treated early at home to reduce your risk of severe disease.

Recently, doctors have returned to basic supportive care and treatments and have experienced better survival rates and patient outcomes. As the pandemic has progressed, doctors have also recognized the need for early outpatient treatment in order to halt the progression and lower the risk of severe disease.

Consider These Steps to Reduce Your Risk

One of those outpatient treatments that has been maligned in the media is a combination of hydroxychloroquine and zinc. Hydroxychloroquine acts as a zinc ionophore, helping to move zinc into the cells. Zinc helps prevent the replication of viruses inside the cell, which is why it has had such good results in shortening the common cold.

Evidence has also suggested that people admitted to the hospital with low zinc levels have a higher likelihood of dying from COVID-19.21 Low levels of vitamin D have also been associated with an increased risk of severe COVID-19 disease. Vitamin D optimization may help prevent infection and reduce the risk of severe symptoms.

In June 2020, I launched an information campaign about vitamin D that included a downloadable scientific report detailing the science behind vitamin D. A randomized double-blind study, published December 2020,22 demonstrated that giving critically ill patients with COVID-19 high doses of vitamin D could significantly reduce the number of days they spend in intensive care and reduce their need for ventilation.

A mathematical reanalysis of data from an earlier trial concluded there’s a “strong role for vitamin D in reducing ICU admission of hospitalized COVID-19 patients.”23 Ivermectin is another drug that’s been found to be useful in all stages of the infection. However, the real strength appears to be as a preventive.

As I reported in “Can Ivermectin Help Prevent COVID-19 Deaths?,” two states in India with high population rates are reporting24 the lowest and second-lowest fatality rates in all of India after having added ivermectin to their treatment protocols.

As reported in Trial Site News, health officials in India had recognized urgency in treating and preventing the illness, but, “Such urgency is in short supply in the U.S., where the single-minded focus is on vaccination.”25

Two other treatments for COVID-19 that have shown significant positive results are vitamin C and the MATH+ protocol. As reported in Nutrients, “Vitamin C’s antioxidant, anti-inflammatory and immunomodulating effects make it a potential therapeutic candidate, both for the prevention and amelioration of COVID-19 infection, and as an adjunctive therapy in the critical care of COVID-19.”26

In response to this landmark review the Alliance for Natural Health launched an international vitamin C campaign.27 Founder and scientific director Rob Verkerk, Ph.D., noted there are several reasons to take supplemental vitamin C:28

  • Your body cannot make it.
  • Most people do not get enough from their diet.
  • Your body’s requirement for vitamin C can increase 10-fold during an infection, disease or physical trauma.

Vitamin C is also a part of the MATH+ protocol developed by the Front Line COVID-19 Critical Care Working Group (FLCCC). You can read more about this protocol, which has been successfully used to treat COVID-19, in “Quercetin and Vitamin C: Synergistic Therapy for COVID-19.”

Consider These Steps to Take Control of Your Health

My personal choice for treating upper respiratory illnesses, including COVID-19, is nebulized hydrogen peroxide. In the video above I demonstrate how the solution should be mixed and administered for the best results.

It’s a home remedy I recommend everyone familiarize themselves with, as in many cases it can improve symptoms in mere hours. You can also use it as a preventive strategy if you know you’ve been exposed to someone who is ill.

The recent events over the past year have aptly demonstrated how crucial it is for you to take control of your health. In the past year there have been a rising number of suicides,29 drug overdoses30 and mental health conditions,31 many of which may have stemmed from fear. It is important to remember you do not have to be afraid and that fear is what is being used to manipulate your behavior.

Take the time to gather the necessary tools you’ll need to protect your health, reduce your risk of infection and hasten healing if you are infected. Then take a few minutes to share this important information with your friends and family members.

Many of the effective preventive and at-home treatment strategies are not shared by the media, as most are advocating you wait with bated breath for a vaccine. You can improve your health and make a difference in others’ lives.

Weekly Health Quiz: Nanoparticles, Glyphosate and Wildlife

1 Deficiency in which of the following nutrients is suspected of driving the decline in wildlife populations across the northern hemisphere?

  • Vitamin D
  • Vitamin B12
  • Thiamine (B1)

    Thiamine deficiency has been identified in dozens of animal species and is now suspected of driving declines in wildlife populations across the northern hemisphere. This means our diets are likely to be low in thiamine, thereby raising the risk for thiamine deficiency in the human population. Learn more.

  • Vitamin A

2 By referring to COVID-19 vaccines as “vaccines” rather than gene therapies, the U.S. government is violating which of the following laws?

  • The U.S. National Health Care Act
  • 42 U.S. Code Section 2651
  • Vaccines Act of 2019
  • 15 U.S. Code Section 41

    By referring to COVID-19 vaccines as “vaccines” rather than gene therapies, the U.S. government is violating its 15 U.S. Code Section 41, which regulates deceptive practices in medical claims. The mRNA injections are gene therapies that do not fulfill a single criteria or definition of a vaccine. Learn more.

3 In 2017, Moderna’s experimental mRNA treatment using lipid nanoparticles was “indefinitely delayed” because it:

  • Wasn’t deemed safe enough to test in humans

    But, as STAT reported in 2017, the treatment was “indefinitely delayed” because it “never proved safe enough to test in humans.” Learn more.

  • Was too expensive to produce
  • Was already on the market
  • Was taken over by another company

4 According to Swedish data, which did not close schools during 2020, teachers’ risk of COVID-19 is:

  • As high as that of 80-year-olds
  • Among the lowest of any profession

    Swedish data shows teachers are among the professions that have the lowest risk of hospitalization and death from COVID-19. Learn more.

  • Double that of the general population in the same age group
  • Lower than that of children

5 If AI takes over jobs and your ability to earn an independent income is destroyed, the introduction of a universal basic income may occur, which:

  • Provides greater equality
  • Gives you guaranteed freedom
  • Makes you dependent on the wealthy elite in control

    … only a fraction of people would likely find work in this AI-driven world, which would necessitate the introduction of a universal basic income. This may initially sound like a good thing, but when your ability to earn an independent income is destroyed, you become dependent on, and at the mercy of, the elite that are in control of that income and the resources surrounding it. Learn more.

  • Is a form of security

6 Which of the following supplements can help mitigate the toxic effects of glyphosate?

  • Glutamate
  • Magnesium
  • Zinc
  • Glycine

    Your body substitutes glycine for glyphosate, and in so doing, poisons the machinery for creating proteins. To mitigate the toxic effects of glyphosate, you can take an inexpensive glycine supplement. Learn more.

This Is the Video to Watch: Infecting W/COVID Swab, the RNA Vaccine, Artificial Intelligence

 Can anybody refute this video?

Originally published on Vaccine Liberation Army this 2 hour documentary exposes everything wrong with what you are being told about covaids. It basically assembles it all together and leaves the choice up to you. Put your hand in the fire and you will get burned. The lie that all men are generally good and have your best interest at heart is completely satanic and anti-Biblical. You can choose to believe it, just as you can choose to stick your hand in the fire!

Answers on OSINT for India 44: Collection Pathologies in a Typical Embassy

Sir, What was the bottom line conclusion from your second graduate thesis? Steele, Robert. National Security C3I3H3–Command, Communications, Computing, Inter-Agency, Inter-Disciplinary, Inter-Operability, Heuristics of the Community Intelligence Cycle, Norman, OK: University of Oklahoma, MPA Thesis. NOTE: above link broken, the thesis is being re-scanned and will be posted by Wednesday as a working PDF link. …

Video (1:09:59) Gene Decode. DUMBs Part 17: Zimbabwe. B2T Including Text Summary by Alert Reader

BitChute Home: Gene Decode. DUMBs Part 17: Zimbabwe. B2T Alert Reader summary of this video: Gene Decode is one of the most informed & intelligent of the intel sources available to us at this remarkable timing.  In this video, he urges us to exercise patience, self-care in the form of strengthening our spiritual connection with …