FULL ARTICLE Benjamin Fulford 6-14-21… “The Removal From Power of Benjamin Netanyahu is a Game Changer”

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“The formal removal from power of Israeli Crime Minister Benjamin Netanyahu is a geopolitical game-changer. Netanyahu’s departure means the messianic Zionist fanatics who want to kill 90% of humanity and rule the survivors from a greater Israel have lost.

““This is momentous to counter KM (Khazarian Mafia) geopolitics,” MI6 sources say. Netanyahu is being taken into protective custody so that he can sing about his hidden controllers before he is killed and silenced, they add.

“…Russian FSB, MI6, Mossad, and CIA sources all agree that humanity faces a common enemy in the form of the Khazarian Mafia (KM). The KM members are now circling their wagons around their G7 slave civilian governments, NATO, and the banksters in Switzerland.”


The Removal From Power of Benjamin Netanyahu is a Game Changer
by Benjamin Fulford, June 14, 2021

The formal removal from power of Israeli Crime Minister Benjamin Netanyahu is a geopolitical game-changer.  Netanyahu’s departure means the messianic Zionist fanatics who want to kill 90% of humanity and rule the survivors from a greater Israel have lost.

“This is momentous to counter KM (Khazarian Mafia) geopolitics,” MI6 sources say.  Netanyahu is being taken into protective custody so that he can sing about his hidden controllers before he is killed and silenced, they add.  Mossad sources insist the real Netanyahu is long gone and what we are seeing is a clone.  However, the MI6 version of events is more in line with what most of us understand as reality.

In any case, some recent news items show how big a change is coming to the Middle East.  Just before Netanyahu was ousted the Mossad linked site DEBKA posted the following:

“Iran’s nuclear breakout may soon be a matter of weeks.  This assessment by U.S. Secretary of State Antony Blinken on Monday, June 8th, confronts the incoming Bennett-Lapid government with its first major challenge – indeed the most ominous test that has faced any past Israeli government.” https://www.debka.com/first-test-for-emerging-israeli-government-iran-is-galloping-towards-breakout-says-blinken/

Do these idiots actually believe anybody listens to them anymore after repeating this weekly for over 30 years?

Now instead we see the Israeli colony of Saudi Arabia trying to make peace with Syria and Iran. https://www.aljazeera.com/news/2021/6/8/times-have-changed-saudi-syria-in-rapprochement-talks

The Russians, for their part, know full well that “Hamas and IS were created by Israeli intel and all their leaders are working for ‘Mossada.’” This is the sort of behavior that prompted a collective decision by the world’s military to tell Israel to “stop or else.”

What has now happened is that the people of Israel decided they did not want to go through another Mossada-like collective suicide.

In any case, Russian FSB, MI6, Mossad, and CIA sources all agree that humanity faces a common enemy in the form of the Khazarian Mafia (KM).  The KM members are now circling their wagons around their G7 slave civilian governments, NATO, and the banksters in Switzerland.

When an FSB source asked if the White Dragon Society was going to hit Geneva, Switzerland with a nuclear strike in order to take out the KM’s Octagon politburo, they were told the WDS “have decided…

that pinpoint surgery is the way to go.”  To this, the FSB replied their analysis of the KM was that “the total top management is 2,500 people and at the very top are 200.”  These people are now being actively hunted by MI6, the FSB, the CIA, and Asian secret societies.

To understand what kind of people we are dealing with we have been given a report by MI6 that former UK Prime Minister Tony Blair’s doctor operated to repair vaginal damage he did to his daughter by repeatedly raping her.  Meanwhile, Chief Cabinet Secretary Simon Case has been taking children from a certain hospital, raping them, and killing them.

That is why death warrants have been issued for these people, they say.

However, MI6 sources say that if push comes to shove “better millions dead than billions, that is how the real world we live and work in is… and it’s not for the faint-hearted.”

This is no exaggeration.  Top-level military and agency personnel have taken action after receiving scientific proof the vaccines being pushed on much of the global population are highly toxic.  That is why suddenly the pandemic and vaccines are vanishing from public discourse.  In a sign of this, some corporate media have started to refer to Covid-19 by its traditional name “the common cold.” https://newyork.cbslocal.com/2021/06/08/reemergence-cold/

Despite this, the G7 slave governments issued a communiqué last weekend where they promised “starting immediately, to vaccinate the world…providing for one billion doses over the next year.”  They added that “ending the pandemic in 2022 will require vaccinating at least 60 percent of the global population.” In other words, they are still bent on genocide. https://www.consilium.europa.eu/media/50361/carbis-bay-g7-summit-communique.pdf

Fortunately, the G7 is increasingly irrelevant.  They accounted for 80% of world GDP when they were founded in 1976 but now, on a real purchasing power parity basis they account for more like 20%.  This did not stop them from promising $40 trillion, way more than their collective GDP, to “fix global infrastructure.”  Needless to say, the $40 trillion is just a giant fiat hallucination.

“Few still remember how our societies and economies were threatened by high inflation 50 years ago,” David Folkerts-Landau, Deutsche Bank chief economist and head of research, wrote in a paper co-written by his colleagues Jim Reid and Peter Hooper.”

The most basic laws of economics, the ones that have stood the test of time over a millennium, have not been suspended.  Explosive growth in debt-financed largely by central banks is likely to lead to higher inflation.”  In other words, there is such a thing known as reality and the fiat bankers have bumped into it.

There was also weird talk in the G7 communiqué about “action to decarbonize areas such as iron and steel, cement, chemicals, and petrochemicals,” as well as “decarbonized mobility including buses, trains, shipping, and aviation.”  With all these weird reports about vaccinated people becoming like magnets, it makes one wonder if, as the Gnostic Illuminati say, the G7 works for a rogue artificial intelligence that also wants to “decarbonize” humans.  In other words, it is working towards a shift from carbon-based life (like us) to silicon-based life.

In any case, “the Military were all watching the G7 summit and laughing,” MI6 promises.  They say the Rothschilds are bankrupt because of lawsuits related to Libor manipulation.  Now, this satanic family is “now desperately clinging to power using their poor cousins the Rockefellers.”

The fake Biden regime has shown itself to be a Rockefeller proxy by brazenly promoting their business interests.  That is why they cut off the Keystone pipeline as the first order of business for their bogus regime.  Also, if you look at their so-called “Three Seas Initiative,” you will see it consists of building ports and pipelines, etc., to allow European countries to import expensive Rockefeller LNG, oil, etc.

The Rockefellers are also desperately trying to woo Russia to join them as junior partners in a new cold war against China when their so-called President Biden meets with Russian power avatar Vladimir Putin in Geneva on June 16th.

Here is the official Russian take on this meeting:

“No one wants a return to the Cold War.  But as was true then, improving security in the Euro-Atlantic region today will require leaders to recognize their mutual interests and act boldly and together to promote them.  The June 16th meeting between the U.S. and Russian presidents in Geneva, Switzerland, offers the opportunity to begin an important new dialogue on strategic stability.  One of history’s lessons is how quickly nations can move from peace to horrific conflict.  In the aftermath, we have looked back and wondered not only how it could have happened, but how it happened so quickly?” https://russiancouncil.ru/en/analytics-and-comments/analytics/advancing-strategic-stability-in-the-euro-atlantic-region-2021-and-beyond/

The Russians are also aware they are dealing with a failed state as “Putin” recently noted on the official Tass news site when he said:

“Problems keep piling up.  And, at some point, they are no longer able to cope with them.  And the United States is now walking the Soviet Union’s path, and its gait is confident and steady.” https://tass.com/economy/1299287

The signs the U.S. is a failed state continue to multiply.  For example, as the chart below shows, the purchasing power of the domestic U.S. dollar (as opposed to the international one) continues to plunge: https://www.zerohedge.com/economics/its-permanent-not-temporary-dollars-purchasing-power-plunged-fastest-pace-1982


Also, all the funny money the Biden people have been distributing in an attempt to bribe the American public has caused 40% of small businesses to raise prices while 48% of these businesses are unable to find workers.

It also turns out that more than half of the unemployment money the U.S. handed out in response to the fake pandemic has been stolen and sent overseas by fraudsters. https://www.axios.com/pandemic-unemployment-fraud-benefits-stolen-a937ad9d-0973-4aad-814f-4ca47b72f67f.html

There is also a continuing slide into anarchy.  For example businessmen in Fell’s Point Maryland threatened to stop paying taxes unless the city government did things like collect trash, enforce parking offenses, stop the illegal sale of drugs and alcohol on the street, and let the police do their job. https://www.scribd.com/document/511058781/Letter-to-City-Leaders-From-Fells-Point-Business-Leaders-6-8-21-Final#from_embed

In Oregon meanwhile, they decided to give the homeless their right to camp and live on public streets and property.  In other words, say goodbye to parks and public streets. https://thepostmillennial.com/oregon-legislature-passes-bill-to-allow-homeless-to-legally-camp-on-public-property/

There is also a continuing descent into violence and lawlessness as this headline illustrates:

“After historically deadly 2020, Atlanta homicides are up nearly 60% in 2021.”https://www.ajc.com/news/after-historically-deadly-2020-atlanta-homicides-are-up-nearly-60-in-2021/N63RJ5OKQZCZVOCNH2D6376S3E/

Also, there were more than 600 mass shootings – those involving four or more people who were shot – in 2020, and that record is expected to be surpassed in 2021.

Even as their U.S. slave regime continues its collapse, the KM is still not planning to go quietly into the night.  They are now threatening to shut down global commerce.  Their World Economic Forum division issued the following veiled threat last week saying, “The key message voiced by experts at WEF and other international platforms is that supply chain security is to become a major cybersecurity issue in 2021.”  They also said “the world is becoming ever more interconnected… In this context, a single vulnerable link is enough to bring down the entire system, just like the domino effect.” https://cyberpolygon.com/about/#link-s181


The G7 communiqué hinted at specific targets by noting “risks to the resilience of the critical global supply chains, in areas such as critical minerals and semiconductors.”  A taste of this came when the Taiwanese government ordered “King Yuan, which is a key supplier for Nvidia, Intel, MediaTek, and many other top global chip developers, to stop all of its foreign laborers from working.  The order was effective immediately, regardless of COVID test results.”

Russian FSB sources for their part say KM mercenaries disguised as “IS,” “Boko Haram” etc. continue to steal gold and other precious minerals from Africa “on behalf of investors residing in the U.S.”

From a military perspective, the way to stop these criminals is to remove their control of central banks, because then they will lose their ability to finance mayhem.  We have talked to IS and other mercenaries and they say they are paid in Swiss francs.  So Switzerland remains a high-priority military target.

Also, KM control of the UN, the WHO, the International Civil Aviation Organization, and the International Maritime Organization needs to be ended.  It was control of these organizations that allowed them to use a fake pandemic to shut down the world economy and blackmail humanity.

A good look also needs to be taken at certain Chinese factions.  There was a report on Jim Stone freelance about students being grabbed at 100 schools in China during lunch hour.  Recently I have been unable to read his reports on my computer but was able to on my iPhone.  However, the report was deleted from my iPhone as I was reading it.  This is a good sign the Rockefellers, as a part of their deal with a certain Chinese faction to get support for their Biden avatar government, handed the keys of Japanese digital censorship to China.

Also, although I do not know why the students were taken, I do recall the head of a Taiwan-based Asian secret society saying that their revenge for SARS “would be unpredictable and worse than you expect.”  The fact that only Westerners have been injected with dangerous vaccines in response to this fake pandemic gives rise to the question of whether or not this was their revenge.  If so, China may be sheltering its best and brightest from the inevitable retaliation that will come if they are proven to be behind the vaccine campaign.

On a final note this week, we got the following intelligence from our source in the secret space program:

“All the news about Antarctica is being pushed now to keep everyone off of what is happening in Greenland.  Russia is working closely with the U.S. military (Trump and Putin) developing a unique underground base that is directly connected with our off-world family.  They are sharing new technologies that are not available here yet.  This is the new area 51.  China is not part of this operation”.

Let us see how this develops as time will tell.

An audio version of this report is now available as an option for subscribers.  Thank you for your support to make this research and analysis possible.


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The Next Pandemic Is Here and Being Ignored

Antibiotic resistance (AR) and antimicrobial resistance (AMR) took a backseat to the COVID-19 pandemic, but it hasn’t gone away. It remains “one of the biggest public health challenges of our time,” as even the U.S. Centers for Disease Control and Prevention (CDC) admits.1

While antibiotic resistance refers to bacteria resistant to antibiotics, antimicrobial resistance is a broader term used to describe resistance to drugs among a variety of microbes, including parasites, viruses and fungi.2

AMR has been declared one of the top 10 global public health threats to humanity,3 but it rarely makes front page news, especially now that COVID has entered the arena.

Not only has the COVID-19 pandemic — and its unprecedented promotion of hand sanitizer, antimicrobials and disinfectants — made AMR worse,4 but it continues to overshadow the growing threat of AMR, which will likely surpass the number of COVID-19 deaths by at least threefold — annually — by 2050. As noted by NewStatesman:5

“The scary thing is, [AMR is] insidious and silent. The latest figures suggest AMR will cause over 10 million deaths per year by 2050. This is more than deaths from cancer and diabetes combined, and triple the current Covid-19 death toll of 3.4 million deaths worldwide since 2019.”

Antimicrobial Resistance Increased During COVID-19 Pandemic

While the world stopped due to COVID-19, the use of antimicrobial agents — for disinfecting surfaces and public spaces and treating patients — increased. The high rates of antimicrobial agent usage in COVID-19 patients are now being blamed for a rapid rise in multidrug-resistant organisms (MDROs), including:6

Extended-spectrum ?-lactamase (ESBL)-producing Klebsiella pneumoniae

Carbapenem-resistant New Delhi metallo-?-lactamase (NDM)-producing Enterobacterales

Acinetobacter baumannii

Methicillin-resistant Staphylococcus aureus (MRSA)

Pan-echinocandin-resistant Candida glabrata

Multitriazole-resistant Aspergillus fumigatus

In many cases, COVID-19 patients have presented with secondary infections with multidrug-resistant organisms. Fungal co-infections in COVID-19 patients are also common, as is antibiotic treatment, with one report from China suggesting that more than 70% of COVID-19 patients received antibiotics.7

Other research suggested 84.7% of hospitalized COVID-19 patients received intravenous antibiotic therapy, while a report published in the Journal of Antimicrobial Chemotherapy stated that up to 95% of COVID-19 patients in hospitals are prescribed antibiotics.8

As for why so many patients were excessively treated with antibiotics, despite COVID-19 being caused by a virus (SARS-CoV-2), researchers suggested that co-bacterial fungal or secondary infections were only part of the reason. Others included:9

  • Since the symptoms of COVID-19, such as cough and fever, may also occur in bacterial pneumonia “clinicians empirically add a broad-spectrum antibiotic despite the suspicion of a viral origin”
  • Anxiety and uncertainty regarding COVID-19 and an absence of effective SARS-CoV-2 treatments potentially drove “widespread and excessive prescription of antibiotics”

Multiple reports point to increased AMR during the pandemic. For instance, incidence of carbapenem-resistant Enterobacterales colonization increased from 6.7% in 2019 to 50% in March to April 2020.10

Excessive Antimicrobials During Pandemic Affect Environment

AMR has clear toxicological effects on the environment, in part because patients excrete a large proportion of drugs they ingest into wastewater, which allows drug residues and drug metabolites to be released into rivers and coastal waters.11

A team from the University of Plymouth in England conducted a risk assessment to determine the potential environmental impact of prescribing COVID-19 patients antibiotics, which revealed, “The data for amoxicillin indicate a potential environmental concern for selection of AMR …”12 The team urged such assessments be carried out in the future to keep tabs on the potentially disastrous effects of pandemic prescribing habits on AMIR:13

“We recommend more extensive environmental assessments be undertaken for all antimicrobial medicines used during pandemics. This will facilitate development of a robust evidence base in order to guide antibiotic prescribing choices that are less likely to increase AMR and have the least environmental impact …”

Even the World Health Organization made it clear that countries were at risk of the accelerated spread of AMR due to the COVID-19 pandemic. They cited data showing that antibiotic use increased throughout the pandemic. About 79% to 96% of people who reported taking antibiotics didn’t have COVID-19 but were taking them in the hopes of preventing infection (antibiotics don’t work against viral infections).14

Further, WHO noted that while about 15% of people with severe COVID-19 may develop a bacterial co-infection that would require antibiotics, 75% of COVID-19 patients were actually receiving such drugs.15

Why Development of New Antibiotics Isn’t the Answer

Clearly alternatives to antibiotics are needed — and fast. It’s been estimated that the pharmaceutical industry will need upward of $37 billion over the next decade to replace antibiotics that no longer work.16 However, drug companies have little financial incentive to innovate new antibiotics, so unless taxpayers end up footing the bill, it’s unlikely that such products will enter the market anytime soon.

There are 43 antibiotics in clinical development, but none of them show much promise for solving rapidly rising AMR, as innovation is stagnant — most “new” antibiotics brought to the market are variations of drug classes that have been around since the 1980s. WHO’s annual Antibacterial Pipeline Report also found that antibiotics currently in development are insufficient to tackle AMR:17

“The 2020 report reveals a near static pipeline with only few antibiotics being approved by regulatory agencies in recent years. Most of these agents in development offer limited clinical benefit over existing treatments, with 82% of the recently approved antibiotics being derivatives of existing antibiotic classes with well-established drug-resistance. Therefore, rapid emergence of drug-resistance to these new agents is expected.”

Pesticides Make Antibiotic Resistance Worse

The overuse of antimicrobials during the COVID-19 pandemic is a driving factor making AMR worse, but it’s only one piece of the puzzle. Widely used herbicides like glyphosate (Roundup) and dicamba (Kamba) also play a role.

Research from University of Canterbury researchers revealed that agrichemicals and antibiotics in combination increase the evolution of antibiotic resistance, such that bacteria may develop antibiotic resistance up to 100,000 times faster when they’re exposed to certain herbicides in the environment.18

Herbicides promote antibiotic resistance by priming pathogens to more readily become resistant to antibiotics.19 This includes Roundup (the actual formulation of Roundup, not just its active ingredient glyphosate in isolation), which was shown to increase the antibiotic-resistant prowess of E. coli and salmonella, along with dicamba and 2,4-D. Rodale News reported:20

“The way Roundup causes this effect is likely by causing the bacteria to turn on a set of genes that are normally off, [study author] Heinemann says. ‘These genes are for ‘pumps’ or ‘porins,’ proteins that pump out toxic compounds or reduce the rate at which they get inside of the bacteria …’

Once these genes are turned on by the herbicide, then the bacteria can also resist antibiotics. If bacteria were to encounter only the antibiotic, they would instead have been killed.

In a sense, the herbicide is ‘immunizing’ the bacteria to the antibiotic … This change occurs at levels commonly used on farm field crops, lawns, gardens, and parks.”

In the U.S., industrial agriculture even uses the antibiotics oxytetracycline and streptomycin as pesticides on agricultural plants, a practice that’s banned in the European Union and Brazil due to rising concerns over antibiotic resistance. But in the U.S., the Environmental Protection Agency approved the “maximum level” of oxytetracycline for use in citrus fruits in December 201821 — just days after approving residues of the drug on fruit.22

Agricultural Antibiotics Cannot Be Ignored

Industrially raised farm animals living on concentrated animal feeding operations (CAFOs) have emerged as another major reservoir of antibiotic-resistant bacteria. Due to poor farming practices, including the use of low doses of antibiotics in animal feed for purposes of growth promotion, antibiotic resistance in farm animals is on the rise, threatening human and animal health along with food production sustainability.

Worldwide, most antibiotics are used not for human illness or companion pets but for livestock. Overall, 73% of the antibiotics sold globally are used in farm animals raised for food, typically on CAFOs.23 Researchers explained the glaring role of CAFOs in antibiotic resistance in Environmental Health Perspectives:24

“This prolonged use of antibiotics, especially at low levels, presents a risk of not killing the bacteria while promoting their resistance by selecting for resistant populations.

The resistance genes can pass readily from one kind of bacteria to another. Thus, workers in the animal units may become colonized with resistant organisms and can pass them on to co-workers and family members or friends.

Consumers of meat may also become colonized through mishandling of raw meat or through insufficient cooking. Ultimately, these genes may pass into pathogens, and diseases that were formerly treatable will be capable of causing severe illness or death.”

In addition, most antibiotics ingested by animals are not metabolized but, rather, excreted. This waste is then applied to soil as a fertilizer, which may then be sprayed with herbicide. The antibiotic-resistant microbes can also be carried elsewhere by houseflies.25

Pandemic ‘Stretched the Limits’ of Optimal Antibiotics Usage

Increased AMR is yet another fallout of the COVID-19 pandemic, which will combine with the already perilous AMR pandemic in progress, resulting in further deaths and environmental destruction. Writing in the International Journal of Antimicrobial Agents, researchers stated, “the ongoing pandemic is stretching the limits of optimal antibiotic stewardship”26 and called for an end to unnecessary use of antimicrobial agents:27

“Moreover, unnecessary use of antimicrobial agents would be associated with a significant economic burden on healthcare systems, which could be directly caused by the drug itself and indirectly caused by healthcare costs for the management of drug-related adverse events … continuing this intervention to curb inappropriate antibiotic usage and surveying the reasons for guideline non-adherence should be conducted within hospitals.”

Beyond this, choosing organic foods, including grass fed meats and dairy products, can help you avoid exposure to antibiotic residues in the food supply, while also supporting food growers who are not contributing to AMR. Unfortunately, as the world continues to put all of its attention on COVID-19, the catastrophe of AMR is getting worse instead of better.

NAC Banned on Amazon, Threatened by FDA

N-acetylcysteine (NAC), a precursor to reduced glutathione, appears to play an important role in COVID-19. According to an April 2020 literature analysis,1 glutathione deficiency may be associated with COVID-19 severity, leading the author to conclude that NAC may be useful both for its prevention and treatment.

NAC has a long history of use as a poison control remedy for acetaminophen poisoning in the emergency room. It neutralizes the toxic effects of the drug by recharging glutathione, thereby preventing liver damage. But the idea that NAC can also be helpful against viral infections is not new. Previous studies2,3 have found it reduces viral replication of certain viruses, including the influenza virus.

In one such study,4 the number needed to treat (NNT) was 0.5, which means for every two people treated with NAC, one will be protected against symptomatic influenza. That’s significantly better than influenza vaccines, which have an NNV (number needed to vaccinate) of 71,5 meaning 71 people must be vaccinated to prevent a single case of confirmed influenza. It’s even better than vitamin D, which has an NNT of 33.6

Early At-Home Treatment Is Crucial

In the video above, MedCram producer and cofounder Kyle Allred interviews Dr. Roger Seheult, a pulmonologist who has been treating COVID-19 patients since the beginning of the pandemic in 2020, about strategies that can significantly reduce your need for hospitalization should you contract this infection.

Among those strategies is the use of NAC, which used to be readily available over the counter and online. Disturbingly, as more information is coming out about the usefulness of NAC, the U.S. Food and Drug Administration is now clamping down on sales.

Since the beginning of this pandemic, global and national health authorities have done everything in their power, it seems, to discourage and prevent people from accessing any treatment that competes with the COVID jab. This appears to be yet another shameful attempt to prevent patients from helping themselves and boost the risk of infections progressing into more serious cases.

Should you come down with symptoms of COVID-19, early treatment is crucial. Not only can it significantly reduce the length of time that you’re sick, early treatment will also minimize your risk of long-hauler syndrome. A summary of the treatment strategies Seheult reviews in more detail in the video is as follows:

  • Monitor your oxygen saturation status using a pulse oximeter. If your oxygen saturation drops below 94% at rest, you should seek medical treatment. Below 90%, you are hypoxic and need supplemental oxygen
  • Use vitamins and other immune-boosting supplements, including vitamins C and D, quercetin, zinc and NAC, and/or medications such as monoclonal antibodies
  • Use immune-boosting strategies such as sleep (melatonin can be used if you’re experiencing poor sleep) and raising your core temperature in a hot bath or sauna
  • Prevent spread at home using ventilation, air filtration and isolation

Amazon Removes All NAC Products

May 6, 2021, Natural Products Insider reported7 that Amazon is removing all NAC products from the site, following warning letters being sent out by the FDA stating NAC cannot be lawfully marketed as a dietary supplement because it was first studied as a drug in 1963.8

Consequently, products containing the ingredient are excluded from the definition of a dietary supplement under section 201(ff)(3)(B)(i) of the Federal Food, Drug & Cosmetic Act (FDCA). The thing is, NAC has been sold as a supplement for 57 years, and the FDA never did a thing about it — until now, when more than a dozen studies are investigating its usefulness against COVID-19.

As reported by Natural Products Insider,9 there are at least 1,170 NAC-containing products in the National Institutes of Health’s Dietary Supplement Label Database. The FDA suddenly put NAC in its crosshairs in July 2020, when it sent out warning letters to seven companies that marketed NAC as a remedy for hangovers.10

CRN’s Legal Arguments as to Why FDA Is Wrong

In December 2020, the trade group for the supplement industry, the Council for Responsible Nutrition (CRN), challenged the FDA’s position, calling it “legally invalid.”11 CRN argued that FDA records fail to prove that the FDCA section in question actually applies to NAC.

In response to a Freedom of Information Act (FOIA) request to the FDA for information proving NAC was investigated as a drug in 1963, all they received was a handwritten letter containing “what appears to be a handwritten approval date of 1963” for an inhaled drug. According to CRN:

“This handwritten notation raises a number of questions about the reliability of this record, not the least of which is whether the approval date was actually 1963 or sometime later, why was the approval data handwritten, when was the notation made, and who made it. This is not the type of document that should be regarded as authentic.”

Moreover, an inhaled substance cannot be treated the same as an orally ingested product, hence the NAC drug approved in 1963, if valid, still would not apply to oral supplements. The FDA did approve an NAC drug for oral-only use in 2016, but by then dietary supplement companies had already been marketing NAC supplements for several decades, and therefore cannot be canceled by a new drug approval. As reported by Natural Products Insider:12

“FDA’s interpretation of section 201(ff)(3)(B)(i) in the warning letters also conflicts with ‘the presumption against statutory retroactivity,’ according to CRN. Mister and Olsen highlighted ‘a well-established canon of statutory interpretation that legislation shall not be read to have a retroactive effect on private rights unless Congress expresses a clear, unambiguous intent to the contrary.’

Section 201(ff)(3)(B)(i) was incorporated in the Dietary Supplement Health and Education Act of 1994 (DSHEA), which went into effect on Oct. 25, 1994.

According to CRN, the exclusionary provision should be not be interpreted to apply to products containing articles approved as drugs before Oct. 25, 1994 because DSHEA’s text and the provision’s legislative history suggests ‘Congress expressed no clear intent for this provision to have a retroactive effect.

Further, Congress created section 201(ff)(3)(B)(i) to protect commercial interests necessary to incentivize new drug development in the wake of DSHEA’s enactment …

A retroactive application of this section does nothing to incentivize new drug development because drugs and supplements that were both on the market prior to DSHEA’s passage already co-existed and drug companies developed these products with no expectation of DSHEA’s protections.’”

CRN further argued the FDA failed to sufficiently explain this sudden change in policy on NAC, thus “rendering it arbitrary and capricious.” According to CRN, before the seven warning letters in July 2020, “it was FDA’s longstanding policy to permit the marketing of dietary supplements containing NAC.”

Even though the agency had reviewed more than 100 notifications’ structure/function claims for NAC-containing supplements over the years, they never raised the drug exclusion clause. In one response to a petition for a qualified health claim, the FDA had even stated that NAC was considered a dietary supplement.

NAC Supplements Continue To Be Sold Elsewhere

Unfortunately, Amazon has apparently decided to side with the FDA, despite the ongoing legal controversy and, as of this writing, has already removed all NAC product listings. Since Amazon owns Whole Foods Market, NAC products may be removed from brick and mortar stores as well. But that doesn’t mean you can’t find NAC elsewhere.

“The Natural Products Association (NPA) … is advising its members to continue selling NAC-containing supplements,” Natural Products Insider writes.13 “FDA hasn’t taken final agency action on NAC, and there’s been debate on such issues as when NAC came to market as a drug …

‘Like we’ve told our members, sell it direct,’ [NPA president and CEO Dan Fabricant] added. ‘Sell it through other vendors because it’s not an unlawful ingredient. This is by no way a closed chapter with FDA on NAC.’”

NAC in COVID-19 Treatment

As mentioned, the FDA’s timing is highly suspect, considering its inaction in previous years, and considering the many studies now looking at NAC in the treatment of COVID-19. At present, ClinicalTrials.gov lists 16 clinical studies underway or completed involving NAC against COVID-19.14 That’s five more than there were in November 2020.

This includes a still-ongoing Phase 2 trial looking at NAC in patients with severe COVID-19. As noted in the trial description:15

“Recent studies suggest that the virus that causes COVID-19 may work by suppressing the immune system, which is the body’s defense against infections and other diseases.

White blood cells called lymphocytes are an important part of this defense, but recently it was found that the number of lymphocytes in a COVID-19 patient’s blood goes down as the infection gets worse and goes up as a patient gets better. N-acetylcysteine has been shown to help increase the number of lymphocytes in the blood when a virus is responsible for lowering it.”

Another recently completed trial16 used inhaled vapor of NAC in combination with diclofenac sodium, menthol and methyl salicylate in patients with mild to moderate COVID-19.

While the findings have yet to be published, they determined that “after regular inhalation of vapor with above medication, oxygen saturation level increased in the study group 384.61% in the morning and 515.79% at night comparing the control group. Furthermore, patients of study group need to stay nearly 1 day less in hospital in comparison to control group.”

Glutathione Depletion Worsens COVID-19 Outcomes

Previous research17 has shown NAC inhibits the expression of proinflammatory cytokines in cells infected with highly pathogenic H5N1 influenza virus. Proinflammatory cytokines also play a crucial role in COVID-19 severity.

Researchers have confirmed that in severe COVID-19 cases, cytokines such as interleukin-6 (IL6), interleukin-10 (IL10) and TNF-? are all elevated.18 Once they reach excessive levels, a so-called cytokine storm develops, causing significant tissue damage. NAC may be able to inhibit this damaging cascade.

In one 2020 paper,19 the authors describe the case of a COVID-19 patient that had glucose 6-phosphate dehydrogenase (G6PD) deficiency, a genetic disorder that can lead to hemolytic anemia, a condition in which red blood cells are broken down faster than they are made.

G6PD deficiency has been shown to facilitate human coronavirus infection (such as the common cold) due to the fact that G6PD depletes glutathione, and some of these patients are also at increased risk of hemolytic anemia when given hydroxychloroquine. As noted in this paper:20

“G6PD deficiency may especially predispose to hemolysis upon coronavirus disease-2019 (COVID-19) infection when employing pro-oxidant therapy. However, glutathione depletion is reversible by N-acetylcysteine (NAC) administration.

We describe a severe case of COVID-19 infection in a G6PD-deficient patient treated with hydroxychloroquine who benefited from intravenous (IV) NAC beyond reversal of hemolysis.

NAC blocked hemolysis and elevation of liver enzymes, C-reactive protein (CRP), and ferritin and allowed removal from respirator and veno-venous extracorporeal membrane oxygenator and full recovery of the G6PD-deficient patient.”

In addition to that G6PD-deficient patient, NAC was also given to nine other COVID-19 patients who were on respirators but did not have G6PD deficiency. In these patients, “NAC elicited clinical improvement and markedly reduced CRP in all patients and ferritin in 9/10 patients.” The authors hypothesize that NAC’s mechanism of action “may involve the blockade of viral infection and the ensuing cytokine storm.”21

That said, they point out that it’s difficult to discern whether these anti-inflammatory effects were specific to the use of NAC, as steroids and other anti-inflammatory drugs were sporadically used. Still, they believe NAC does have the ability to reduce inflammation in patients with COVID-19.

Additional Research Findings

Other papers have also been published describing how NAC can benefit COVID-19 patients, including the following:

An October 2020 paper22 in Medical Hypotheses cited evidence that NAC helps improve redox status, “especially when under oxidative stress,” replenish glutathione stores, increase T cells, inhibit the NLRP3 inflammasome pathway and decrease plasma TNF-?.

“Mediation of the viral load could occur through NAC’s ability to increase cellular redox status via maximizing the rate limiting step of glutathione synthesis, and thereby potentially decreasing the effects of virally induced oxidative stress and cell death,” the authors wrote, adding:

“We hypothesize that NAC could act as a potential therapeutic agent in the treatment of COVID-19 through a variety of potential mechanisms, including increasing glutathione, improving T cell response, and modulating inflammation. In this article, we present evidence to support the use of NAC as a potential therapeutic agent in the treatment of COVID-19.”

Another August 2020 paper, “Rationale for the Use of N-acetylcysteine in Both Prevention and Adjuvant Therapy of COVID-19,” published in the FASEB Journal, also explained the many potential benefits of NAC:23

“COVID-19 may cause pneumonia, acute respiratory distress syndrome, cardiovascular alterations, and multiple organ failure, which have been ascribed to a cytokine storm, a systemic inflammatory response, and an attack by the immune system. Moreover, an oxidative stress imbalance has been demonstrated to occur in COVID-19 patients.

NAC … has been proposed not only as a mucolytic agent, but also as a preventive/therapeutic agent in a variety of disorders involving GSH depletion and oxidative stress … Thiols block the angiotensin-converting enzyme 2 thereby hampering penetration of SARS-CoV-2 into cells.

Based on a broad range of antioxidant and anti-inflammatory mechanisms … the oral administration of NAC is likely to attenuate the risk of developing COVID-19, as it was previously demonstrated for influenza and influenza-like illnesses.

Moreover, high-dose intravenous NAC may be expected to play an adjuvant role in the treatment of severe COVID-19 cases and in the control of its lethal complications … including pulmonary and cardiovascular adverse events.”

A more recent paper24 published on the preprint server ChemRxiv.org, June 1, 2021, hypothesizes NAC may be used to perturb the spike protein by reducing its solvent accessible disulfide bond, “thereby disintegrating its structural architecture.” By so doing, the virus loses its capacity to infect your cells.

Analyses have shown NAC causes a threefold weakening of the spike protein’s binding affinity with the ACE2 receptor. Other experiments have shown NAC inhibited SARS-CoV-2 replication in VEroE6 cells by 54.3%. According to the authors, “Our observed results open avenues for exploring in vivo pharmaco-preventive and therapeutic potential of NAC for COVID-19.”

NAC Shown to Improve Variety of Lung-Related Problems

Studies have also demonstrated that NAC helps improve a variety of lung-related problems, including pneumonia and ARDS,25 both of which are common characteristics of COVID-19. For example:

Research26 published in 2018 found NAC reduces oxidative and inflammatory damage in patients with community-acquired pneumonia.

Another 2018 study27 found NAC improves post-operative lung function in patients undergoing liver transplantation.

A 2017 meta-analysis28 found a significant reduction in ICU stays among ARDS patients treated with NAC (although there was no significant difference in short-term mortality risk).

A 2007 study29 concluded NAC improves ARDS by “increasing intracellular glutathione and extracellular thiol molecules” along with general antioxidant effects.

A 1994 study30 found NAC enhances recovery from acute lung injury, significantly regressing patients’ lung injury score during the first 10 days of treatment, and significantly reducing the need for ventilation. After three days of treatment, only 17% of those receiving NAC needed ventilation, compared to 48% in the placebo group.

NAC is also a well-known mucolytic used to help clear mucus out of the airways of cystic fibrosis patients.31 Some studies also suggest NAC can help reduce symptoms of COPD and prevent exacerbation of the condition.32

NAC Also Protects Against Blood Clots

Lastly, NAC may also protect against hypercoagulation that can result in stroke and/or blood clots33 that impair the ability to exchange oxygen in the lungs. Many COVID-19 patients experience serious blood clots, and NAC counteracts hypercoagulation,34,35,36 as it has both anticoagulant and platelet-inhibiting properties.37

A 2017 paper38 also found NAC has potent thrombolytic effects, meaning it breaks down blood clots once they’ve formed. This is largely thanks to the sulfur in NAC (from cysteine). The sulfur reduces the intrachain disulfide bonds by von Willebrand factors that have polymerized by dissociating the sulfur bonds holding them together, thus contributing to the clot.

Once von Willebrand factor sulfur bonds are broken, the clots start to dissolve and the blood vessels open up again allowing for exchange of oxygen and carbon dioxide. According to the authors,39 “NAC is an effective and safe alternative to currently available antithrombotic agents to restore vessel patency after arterial occlusion.” (Restoring vessel patency means the blood vessel is now unobstructed so that blood can flow freely.)

Two additional papers40,41 show the same thing. Importantly, NAC’s mechanism of action does not appear to increase bleeding disorders like heparin does, so it would likely be a safer alternative to the heparin used in the MATH+ protocol.

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