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|(Natural News) Neutral reporting, or what used to be known as journalism, should be completely done away with, according to Los Angeles Times opinion columnist Jackie Calmes – and for holding this opinion, Calmes is being celebrated by her fellow far-left media workers. In an Oct. 15 op-ed, Calmes whined about the “journalist pressure” that…|
Fisetin is a flavonoid molecule that’s found in fruits and vegetables. An animal study published in July 20211 demonstrated that it may help reduce the mortality rate in older adults with COVID-19. A human study2 is underway to analyze the effect it may have on elderly patients with COVID-19.
There are nearly 6,000 flavonoids3 found in fruits, vegetables, herbs and medicinal plants. Flavonoids are also antioxidants and have a number of subclasses, including flavanols, flavones and flavanones.4 During 2020, there was a growing focus on the value of antioxidants in the fight against infectious diseases.
As the science grows, researchers are becoming interested in individual flavonoids for the positive effect they can have on human health. Past research has suggested that fisetin may help extend a healthy life span by acting as a senolytic.5
These are a class of molecules that can selectively induce the death of senescent cells. Currently, there are 16 research studies registered with ClinicalTrials.gov studying fisetin.6 Of these, 13 are in the initial stages, either enrolling, recruiting or not yet recruiting participants.
Flavonoid compounds are well-known for their antioxidant, anti-inflammatory, anticarcinogenic and antimutagenic properties.7 They have become indispensable in a variety of applications including the pharmaceutical, nutraceuticals and cosmetic industries. Although scientists are continuing to study the mechanism of action flavonoids’ use in the body, the plant derivatives have been widely used for centuries.
Fisetin Reduced the Burden of COVID in the Lab
Many of the biological effects that flavonoids have on the human body are related to modulating cell signaling cascades.8 This is how they protect against inflammation, thrombogenesis, diabetes and cancer development. Past studies have shown promising results when supplementation is used to improve glycemic control, enhance cognitive function, or in the prevention of cancer.
Fisetin is being studied to help reduce the severity of COVID-19 in elderly patients.9 In an animal study10 published in July 2021, researchers studied the response to stress signals that were associated with senescent cells known to increase in number with age.
They demonstrated that senescent cells increase the risk of severe COVID-19. Since the senescent cells secrete proinflammatory factors, they hypothesized these may heighten the proinflammatory response and raise the risk of cytokine storms and multi-organ failure.
To test the hypothesis, the researchers used human cells in a lab study and old mice that were challenged with lipopolysaccharide. The results demonstrated that senescent cells increased the susceptibility to SARS-CoV-2 and induced hyperinflation. When the researchers used senolytic compounds to reduce the burden of senescent cells, the mortality declined.
The senolytic compound they used to induce the death of senescent cells was fisetin. They believe the data suggests “senolytics might protect others vulnerable to adverse COVID-19 outcomes in whom increased SnCs [senescent cells] occur (such as in obesity or numerous chronic diseases).”11
In one of the studies, the researchers found older mice exposed to a normal microbial environment, including SARS-CoV-2-related mouse beta coronavirus, experienced 100% lethality within 2 weeks. By comparison, those exposed to the same microbes but treated with fisetin had a significant improvement in survival — 64% of the male mice and 22% of the females survived long-term with an extension in lifespan for both sexes.12
Fisetin Being Tested Against COVID in an Aging Population
Announcement of a human trial was published in August 2021 in the Journal of the American Geriatrics Society,13 in which researchers plan to evaluate supplementation with fisetin in elderly adults residing in skilled nursing facilities. Past research has demonstrated that fisetin was a senolytic in animal models.
However, until recently, the only senolytic therapy that had demonstrated effectiveness in humans was a combination of quercetin and dasatinib.14 Dasatinib goes by the trade name SPYRCEL, which is a targeted therapy used in the treatment of chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia.15
The promising senolytic results of fisetin in animal studies increases the potential for senolytic treatments in humans without using chemotherapy-targeted drugs. The new clinical trial using fisetin in older patients is being funded by the National Institutes of Health and conducted by Mayo Clinic researchers.16
The researchers are engaging residents in skilled nursing facilities who were PCR positive for SARS-CoV-2 and age 65 or older. Data collection was estimated to start in October 2021 and primary completion is estimated to be by December 2023.17 The primary outcome measure is a change in severity of COVID-19.
The researchers are seeking to assess whether fisetin can help prevent the disease progression and alleviate complications. They plan to enroll 150 patients who will receive either a placebo with no active ingredients or fisetin.
The scientists mention clinical trials that are also ongoing evaluating the efficacy of fisetin against multiple disorders associated with aging, such as frailty, osteoporosis, cardiovascular and lung diseases, and obesity and diabetes.18
Reducing Senescent Cells May Be Key to Healthier Aging
Researchers believe that a larger number of senescent cells, which develop as an individual ages, contributes to a susceptibility of chronic disease and infections, such as COVID-19.19 Senescent cells are metabolically active and resist apoptosis.
However, they don’t divide, and researchers have found higher numbers of senescent cells in older adults with chronic disease. The study that used a combination of dasatinib and quercetin was performed in Rochester, Minnesota, by the Mayo Clinic researchers.
The team engaged participants who had diabetes-related kidney disease. James Kirkland, Ph.D., was the senior author. He talked about senescent cells and the importance of the research on a range of human illnesses:20
“Senescent cells can develop in all mammals in response to disease, injury, or cancerous mutations. Senolytic drugs do not interfere with generation of senescent cells, which could lead to cancer. However, once formed, senescent cells can contribute to developing cancers, multiple other diseases, and consequences of aging.
By targeting senescent cells with senolytics in mice, we can delay, prevent, or treat multiple diseases and increase health and independence during remaining years of life. As we increase our understanding of these drugs and their effects, we hope there may be benefits for a range of human diseases and disorders.”
Historically, cellular senescence was thought to be irreversible.21 Senescent cells are resistant to apoptosis.22 This mechanism of programmed cell death protects against the development of cancer.
Senescent cells have also lost their ability to proliferate. There is a multifunctional nature of cellular senescence that has a greater effect than tumor suppression. It may also be involved in wound healing, tissue repair and visible signs of aging.23
Your body uses apoptosis to remove damaged cells harmed through injury or disease. However, as cells become resistant to apoptosis, it can contribute to a weakened immune system.24 Scientists at UC San Francisco25 have been investigating alternatives to senolytic therapies by approaching it from an immunotherapy standpoint.
They have been researching invariant natural killer T (iNKT) cells which function as a surveillance system. When these become less active with age, it can also lead to a reduction in function to eliminate cells with irreparable DNA damage. Using this alternative pathway, scientists found that by removing senescent cells through an activation of iNKT cells they could affect positive change on diabetes and lung fibrosis.26
More Health Benefits Associated With Fisetin
As a senolytic, fisetin may have even greater health benefits. While the compound is naturally occurring in fruits and vegetables, you likely cannot get a therapeutic amount from food alone. As scientists continue to work out the proper dosing for fisetin, there is likely much benefit to adding some of these fisetin-containing foods to your diet.27
|Food||Fisetin in micrograms/gram (g)|
|Cucumber (with skin)||0.1|
As you can see, strawberries have the greatest amount of fisetin. However, scientists have suggested you would need approximately 37 strawberries each day to get the benefits from fisetin.28 Paul Robbins, Ph.D., is a professor of biochemistry, molecular biology and biophysics at the University of Minnesota medical school.29
He believes that knowing it can have a positive impact on human health is good news, but more work continues to be needed. “These results suggest that we can extend the period of health, termed health span, even towards the end of life,” Fisetin told MediBulletin Bureau. “But there are still many questions to address, including the right dosage, for example.” Fisetin has been shown to:
Encourage anti-inflammatory action — Fisetin has been shown to suppress the production of inflammatory cytokines. While noting a flavonol-rich compound containing fisetin could be a potential therapeutic agent in the treatment of inflammatory conditions, one group of study authors noted:30
Help prevent cancer — Given its well-known anti-inflammatory, antioxidant and antiproliferative properties, fisetin can play a role in helping to prevent cancer. To date, among other effects, fisetin has been shown to:
Inhibit bone-damaging glycation — Glycation, a process in which sugar molecules bond to certain proteins and lipids in your body, results in bone-damaging Advanced Glycation End (AGE) products.
According to Vivian Goldschmidt, founder of the Save Institute, a branch of which focuses on osteoporosis prevention, these molecules destroy collagen, the cartilage-like material that gives your bones tensile strength.36 Due to its beneficial interaction with proteins found in your body, one study indicates fisetin arrests the glycation process.37
Maintain your glutathione levels — According to a 2009 study, fisetin has been shown to help maintain your glutathione levels, particularly during times of increased oxidative stress.38
The study authors stated, “Fisetin not only has direct antioxidant activity, but it can also increase the intracellular levels of glutathione, the major intracellular antioxidant.”39 Glutathione is also known as the “master antioxidant.”40
Protect brain function — A 2014 study41 published in Aging Cell suggests fisetin may have the ability to stave off age-related memory associated with Alzheimer’s disease and other types of dementia in an animal model. The researchers suggested fisetin can act on many of the target pathways implicated in Alzheimer’s disease.
They also found oral administration in mice aged 3 to 12 months prevented the development of learning and memory deficits. The study authors suggested “our results demonstrate fisetin, a compound that activates multiple, well-defined neuroprotective pathways, may provide a new approach to the treatment of [Alzheimer’s disease].”42
Stabilize resveratrol — Similar to other flavonoids, fisetin has been shown to inhibit the hepatic and duodenal sulphation of resveratrol,43 thus improving the bioavailability of this powerful anti-inflammatory polyphenol found in red wine and the skins of certain fruits.
In early September 2021, U.S. Sen. Elizabeth Warren sent a letter1 to Andy Jassy, chief executive officer of Amazon.com, demanding an “immediate review” of Amazon’s algorithms to weed out books peddling “COVID misinformation,” stressing that Amazon’s sale of such books was “potentially unlawful.”2,3,4
Warren specifically singled out my book, “The Truth About COVID-19,” co-written with Ronnie Cummins, founder and director of the Organic Consumers Association (OCA), as a prime example of “highly-ranked and favorably-tagged books based on falsehoods about COVID-19 vaccines and cures” that she wanted banned.
“Dr. Mercola has been described as ‘the most influential spreader of coronavirus misinformation online,” Warren wrote,5 adding: “Not only was this book the top result when searching either ‘COVID-19’ or ‘vaccine’ in the categories of ‘All Departments’ and ‘Books’; it was tagged as a ‘Best Seller’ by Amazon and the ‘#1 Best Seller’ in the ‘Political Freedom’ category.
The book perpetuates dangerous conspiracies about COVID-19 and false and misleading information about vaccines. It asserts that vitamin C, vitamin D and quercetin … can prevent COVID-19 infection … And the book contends that vaccines cannot be trusted …”
Warren Fancies Herself Above the Law
Warren should know that as a government official, it is illegal for her violate the U.S. Constitution, and pressuring private businesses to do it for her is not a legal workaround.
Since she willfully ignores the law, Cummins and I, along with our publisher, Chelsea Green Publishing, and Robert F. Kennedy Jr., who wrote our foreword, are suing Warren, both in her official and personal capacities, for violating our First Amendment rights. The federal lawsuit, in which Warren is listed as the sole defendant, was filed in the state of Washington. As noted in our complaint:
“Once upon a time, the First Amendment was understood to guarantee that books challenging governmental orthodoxy could be sold without fear of governmental intimidation or reprisal.
Almost sixty years ago, in Bantam Books v. Sullivan, 372 U.S. 58 (1963), the Supreme Court held that state officials violated the First Amendment by sending letters to booksellers warning that the sale of certain named books was potentially unlawful.
The ‘vice’ in such letters and in the ‘veiled threat’ of legal repercussions they communicated, explained the Court, is that they allow government to achieve censorship while doing an end-run around the judiciary, ‘provid[ing] no safeguards whatever against the suppression of … constitutionally protected’ speech, thus effecting an unconstitutional ‘prior restraint.’
It made no difference that the officials who sent the letter lacked the ‘power to apply formal legal sanctions’ — i.e., that the officials did not themselves have the power to sanction or prosecute the booksellers in any way. Indeed this fact made the unconstitutionality more apparent.
The officials ‘are not law enforcement officers; they do not pretend that they are qualified to give or that they attempt to give distributors only fair legal advice … [T]hey acted … not to advise but to suppress.’
It also made no difference, the Court expressly found, that the letters were framed as mere ‘exhort[ation]’ or that the booksellers were in theory ‘free’ to ignore the letters, because the officials had ‘deliberately set about to achieve the suppression of publications deemed ‘objectionable’,’ and ‘people do not lightly disregard public officers’ veiled threats.’
Today, certain members of the United States Congress have apparently forgotten, or think they are above, the law set forth in Bantam Books.”
Warren’s Attack on Constitutionally Protected Speech
There’s no doubt our book, “The Truth About COVID-19,” is constitutionally protected speech, and that Warren’s letter is calling on Amazon to suppress protected speech.
In our book, we share viewpoints, ideas, opinions, verifiable facts and factual hypotheses that our federal government just so happens to disfavor, as it counters their chosen narrative that SARS-CoV-2 emerged naturally, cannot be prevented by any means other than experimental gene therapy, and cannot be treated by any other means than certain experimental and exorbitantly costly drugs.
Since the start of the pandemic, government has systematically sought to suppress the kind of information shared in our book, using the same tactic as Warren used against us here — warning Internet-based companies that if they don’t censor these views, the full weight of the government’s wrath will be turned against them. As explained in our complaint:
“The term ‘vaccine misinformation’ as Warren uses it is propagandistic and false. As she uses it, ‘vaccine misinformation’ refers to any speech challenging the safety and efficacy of the COVID vaccines, even when that speech consists of factually accurate information or protected opinion …
On September 10, 2021, as a direct result of Warren’s letter, a major national bookseller chain, Barnes and Noble, notified the publisher of The Truth About COVID-19 by email that it would no longer sell the work as an e-book. Barnes and Noble has — for now — reversed that decision.
It is impossible for Plaintiffs to know with certainty whether, as a result of Warren’s letter, Amazon is now covertly demoting, downgrading, or otherwise suppressing The Truth About COVID-19 in numerous ways that would be hidden from view, but Plaintiffs believe that Amazon is in fact covertly taking such action.
Even if no bookseller in the country had yielded to Warren’s threats, her letter would still be actionable as a clear violation of the First Amendment.
In Backpage.com, LLC v. Dart, 807 F.3d 229 (7th Cir. 2015) (Posner, J.), relying on Bantam Books, the Court held that a governmental official ‘violates a plaintiff’s First Amendment rights’ if by ‘threat’ or ‘intimidation’ the official attempts to induce ‘a third party’ to stop ‘publishing or otherwise disseminating the plaintiff’s message,’ and emphasized that ‘such a threat is actionable and thus can be enjoined even if it turns out to be empty — the victim ignores it, and the threatener folds his tent.’
Such threats go ‘by the name of ‘prior restraint,’ and a prior restraint is the quintessential first-amendment violation.’ Accordingly, Plaintiffs ask this Court to vindicate clearly established law, to vindicate Plaintiffs’ constitutional rights, to vindicate the First Amendment itself, by declaring Warren’s conduct unconstitutional and by enjoining her from repeating such conduct in future.”
Warren Calls Out ‘Misinformation’ With Misinformation
In our complaint, we also emphasize the fact that Warren’s claims of misinformation are themselves misinformation. For example, Warren claims our book falsely “asserts that … vitamin D … can prevent COVID-19 infection.” According to Warren, this claim has no scientific basis. This is clearly and verifiably false as there are many studies, published in 2020 and 2021, supporting this claim.
For example, in May 2021, the National Institutes of Health’s website, PubMed.gov, published a Journal of Medical Virology article titled “Vitamin D Deficiency Is Associated With COVID-19 Positivity and Severity of the Disease.”6 Many other scientific articles have also linked vitamin D deficiency with a higher risk of COVID infection, more severe outcomes and increased rates of death.
Indeed, a recent systematic review7 of the literature, posted on the U.S. National Library of Medicine, which is another National Institutes of Health website, concluded that “blood vitamin D status can determine the risk of being infected with COVID-19, seriousness of COVID-19, and mortality from COVID-19.
Therefore, maintaining appropriate levels of Vitamin D through supplementation or natural methods … is recommended for the public to be able to cope with the pandemic.” As noted in our complaint:
“Thus while Warren professes to champion true COVID information to save lives, she is purveying false information that could lead to COVID deaths. Warren is telling people that vitamin D levels don’t matter for COVID, when in fact — as readers would learn from The Truth About COVID-19 — correcting vitamin D deficiencies could save their lives.
By her own logic and according to her own demands, every major social media platform should have banned Warren’s letter as ‘COVID misinformation.’ But officials like Warren only denounce ‘COVID misinformation,’ demand its censorship, and threaten legal repercussions when the statements in question challenge the COVID narrative they support — not when they themselves are misrepresenting the truth about COVID-19.
Warren’s letter further accuses The Truth About COVID-19 of disseminating ‘false and misleading information about vaccines,’ including by (in Warren’s words) ‘contend[ing] that vaccines cannot be trusted.’
The book’s stated thesis about the COVID vaccines is that their effectiveness ‘has been wildly exaggerated and major safety questions have gone unanswered.’ This statement is accurate and well within the bounds of constitutionally protected opinion …
Warren’s letter further cites a June, 2021, review of The Truth About COVID-19 that purports to list examples of the book’s ‘misinformation,’ the first of which is the following: ‘the authors argue that the SARS-CoV-2 coronavirus was engineered in a laboratory in Wuhan, China.’ It is true that The Truth About COVID-19 argues that that ‘the preponderance of evidence’ supports the lab-leak theory of the origins of the COVID virus.
But the claim that this position is ‘misinformation’ is, once again, itself misinformation. The lab-leak theory — long denounced as a ‘conspiracy theory’ by federal actors and suppressed on social media — is in fact supported by substantial and growing evidence. See, e.g., Wall St. Journal, ‘Science Closes In on Covid’s Origins: Four studies — including two from WHO — provide powerful evidence favoring the lab-leak theory,’ Oct. 5, 2021.8
The review’s next example of the supposed ‘misinformation’ in the The Truth About COVID-19 is this: the book ‘insists multiple times that the public health measures and restrictions will be permanent. Not true.
The CDC announced that fully vaccinated Americans could resume activities without wearing masks or physically distancing, resume domestic travel, and refrain from quarantine even when following a known exposure to the virus if they remain symptom-free.’
This CDC announcement obviously proved to be false, while the prediction made in The Truth About COVID-19 that health restrictions would continue after vaccination has proved more accurate.
Moreover, it is not the case that the Truth About COVID-19 ‘insists’ that these restrictions will be permanent — it says that certain restrictions on our liberty, beginning in the pandemic, will ‘probably’ be permanent, reflecting a humility about the certainty of one’s assertions that Warren might have profited from.”
This Is Only the Beginning
As noted in a press release by Cummins, this lawsuit is just the beginning. OCA and I are launching a campaign to fight back against the censorship that is taking root. This includes unraveling the threads that lead back to the fake fact checkers and disinformation agents in the media, but all of this will take time, so be patient.
It’s also a costly venture, so if you can afford it, consider making a donation to the OCA. As a thank you, I will match your donations dollar for dollar during the month of November.
As explained by Cummins:
“OCA’s federal lawsuit, filed jointly with Dr. Mercola, Robert F. Kennedy Jr. and Chelsea Green books is not just directed against Elizabeth Warren, but is intended to establish a legal precedent against the increasing censorship, slander, and intimidation coming from a wide variety of government, corporate, and media sources.
This Big Pharma/Big Media/Big Government Inquisition is fueled by disinformation and dark money coming from powerful international public relations firms such as the Publicis Groupe and front groups such as the so-called Center for Countering Digital Hate (CCDH).
We are under attack, not because we are purveyors of dangerous disinformation and hate, as Warren and her Establishment cohorts allege, but rather because, in the midst of an international health, economic, and political crisis, we are trying to expose the truth about the lab origins of this catastrophe, and explain how preventive and natural medicine and health, healthy organic food, natural supplements, low-cost generic drugs, strong immune systems, and a healthy environment are our best defenses against chronic disease and engineered pathogens.
We are not anti-vaccine, but rather pro-vaccine safety. We are not purveyors of disinformation, but rather firm defenders of free speech, unobstructed scientific inquiry, and freedom of choice …
We are castigated as ‘conspiracy theorists’ for publicizing the behind-the- scenes machinations of billionaires like Bill Gates, the World Economic Forum, and their ‘Hall of Shame’ collaborators9 in the military-industrial complex.
We are under siege for exposing the existential risks of genetic engineering and lab manipulation, a mad science not only contaminating our food, seeds and animals, but essentially weaponizing pathogenic viruses, bacteria, and insects, part of a catastrophic biological and medical arms race that threatens us all.
We are saddened and alarmed by the now routine attacks on free speech, free association, and medical freedom of choice. We are troubled by the extreme polarization and anger poisoning the body politic, and the debilitating impact of fear-mongering and shaming on our children and the public at large.
We are alarmed by the collateral damage to our health, our psyches, and the entire social fabric by government authoritarianism, virologists and gene engineers playing God, and Big Pharma greed …
America, and the once-hoped-for community of nations, are accelerating toward self-destruction. The body politic is sick, frightened, angry, and divided. People have apparently forgotten how to talk to one another when we disagree on politics, COVID responses, vaccine safety, and a range of other polarizing government dictates.
Former friends and co-workers have become enemies. Meanwhile the forests are burning. Water resources are diminishing … Our children and the most vulnerable are forced to struggle harder than ever, just to survive and preserve their sanity, making it harder and harder maintain a positive outlook, enjoy every day life, much less achieve true happiness.
If COVID-19, the product of mad science and insatiable greed, has taught us anything, it’s that we must transform our food and farming systems and take control of our health.
We must acknowledge, prevent, and resolve the dietary, environmental, and public health-related comorbidities of our ailing population, strengthen our immune systems to fight off chronic disease and pathogens, and provide special protection for the most vulnerable.
We must bring profit-at-any-cost corporations, captured media and regulatory agencies, indentured politicians, Silicon Valley surveillance capitalists, out-of-control genetic engineers, virologists, and bioweapons profiteers to heel.”
Stop the Madness
To this end, OCA has launched a Stop the Mad Science campaign. This global grassroots campaign aims to ban the engineering of viruses, bacteria and all potential pandemic pathogens (PPPs). Mounting evidence suggests COVID-19 was indeed the result of gain-of-function (GOF) research, paid for in part by U.S. taxpayers and carried out by U.S. and Chinese researchers.
Unless we put an end to this kind of dangerous research (and it goes on worldwide, not just in the U.S. and China), COVID won’t be the last manmade pandemic we’ll have to face. More than 65,000 people have already signed the petition in support of this effort. Please add your signature here if you haven’t done so already. As noted by Cummins:
“Current ongoing experiments, routinely funded with our tax dollars, that need to be stopped immediately include genetically engineering SARS-CoV-2 so that it can overcome or bypass natural immunity; combining the SARS-CoV-2 virus with deadly anthrax bacteria; engineering the bird flu and Ebola to be more transmissible; and other criminally insane experiments — hiding behind the excuse that lab and genetic engineering of pathogens are necessary for ‘biodefense’ and ‘biomedicine.’
Over the next six months we will begin to organize protests and picket lines outside the GoF labs and institutions where these dangerous experiments are being carried out. These street protests will be amplified by public education, petition gathering, litigation, and grassroots lobbying.”
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