By Anna Von Reitz
A recent study published in the New England Journal of Medicine1 discovered that the rate of cardiovascular events and death were lower in the group of individuals who used a salt substitute with potassium than in those who used regular salt. The salt substitute was 75% sodium chloride and 25% potassium chloride.
In the interview above with James DiNicolantonio, PharmD., we discuss how salt has been vilified in the past several decades and the possible impact this had on the development of chronic diseases, including high blood pressure and obesity. The interview was in 2017, just after the publication of his book “The Salt Fix: Why the Experts Got It All Wrong — and How Eating More Might Save Your Life.”
In today’s culture, most people think of salt as seasoning for their food. But historically, salt was necessary for the preservation of food and was inextricably intertwined with trade.2 Salt was highly valued, and the word salary is actually derived from the word salt.
It was used as a method of currency and was crucially important economically to many cultures. According to historians, salt played a prominent role in the exploration of the Pacific Northwest in America, was used by the British as a leverage tool in the American Revolution and played a key role in defeating civilian and military morale in the South in the Civil War.
DiNicolantonio first became interested in salt when he was working as a community pharmacist.3 His patients were complaining of new symptoms after their physician put them on a low-salt diet for their high blood pressure. The symptoms included muscle fatigue, heart palpitations, muscle spasms and cramps.
He advised his patients to talk with their doctors and ask more questions about the necessity for using a low-salt diet. He also encouraged them to request a serum sodium blood test to determine if they had low salt levels.
His patients found that after adding salt back into their diet the symptoms disappeared. DiNicolantonio believed this was a real indication that low salt diets were not “panning out in the real world.”4
Potassium Salt Substitute Lowered Cardiovascular Events
The original “Dietary Approaches to Stop Hypertension” (DASH), was published in 1997 in the New England Journal of Medicine.5 The researchers enrolled 459 adults who had blood pressure of less than 160/95. After eating a control diet low in fruits and vegetables and dairy products for three weeks, they were randomly assigned to one of three diets.
One group of participants ate a diet rich in fruits and vegetables, the second ate the control diet and the third ate a combination of the two. The researchers concluded, “A diet rich in fruits, vegetables and low-fat dairy foods and with reduced saturated and total fat can substantially lower blood pressure.”6 At the time of publication, national guidelines also recommended a low-salt diet.
The intervention diet had a salt content of approximately 3 grams per day, with higher levels of potassium, magnesium and calcium. The researchers wrote, “Nonetheless, known diet-related determinants of blood pressure (sodium chloride, body weight and alcohol) could not have accounted for the reductions in blood pressure, because changes in these potential confounders were small and similar for all the diets.”7
In other words, they found that low-salt diets we’re likely not responsible for the reductions in blood pressure that were found in those eating a whole-food diet. But later they wrote it was “noteworthy” that reductions happened with a “sodium intake of approximately 3 grams per day and consumption of two or fewer alcoholic drinks per day.”8 Twenty years later the diet is still considered an important advance in nutritional science. According to one paper:9
“It emphasizes foods rich in protein, fiber, potassium, magnesium, and calcium, such as fruits and vegetables, beans, nuts, whole grains, and low-fat dairy. It also limits foods high in saturated fat and sugar. DASH is not a reduced-sodium diet, but its effect is enhanced by also lowering sodium intake.”
Yet it has been the salt consumption in the DASH diet that has received the greatest attention. The recent data are from the Salt Substitute and Stroke Study10 which sought to determine if using a salt substitute that contained 75% sodium and 25% potassium could have an effect on the rate of major cardiovascular events, stroke and death.
While the endpoint of the DASH diet was to measure blood pressure reduction in a small number of participants, the Salt Substitute study involved people in 600 villages across rural China and used endpoint measurements that clearly had an impact on health.
The researchers chose participants who were 60 years old and older and had high blood pressure. Others were chosen because they had a history of stroke. The researchers randomly assigned villages to use a salt substitute or regular salt11 and followed up for a mean of 4.74 years.12
Those consuming the salt substitute had a lower rate of stroke, major cardiovascular events and death. The rate of hyperkalemia, or high levels of potassium in the blood, was only slightly higher in those using a salt substitute.13 While these results are encouraging, the researchers did not measure whether the participants were first deficient in potassium, also crucial for cardiovascular health.
Low-Salt Recommendations Likely Does More Harm
The original studies linking a low salt diet to high blood pressure began in the 1940s with Dr. Lewis Dahl. At the time of his death, he was chief of staff at the Hospital of Medical Research Center, Brookhaven National Laboratory, New York. In 1956 he concluded that a high-salt diet was an important factor in high blood pressure.14
In my interview with DiNicolantonio, he referred to Dahl as “the Ancel Keys of salt,”15 in reference to the way Keys’ and Dahl’s studies were structured.16,17 The method behind Keys’ study was seriously flawed, with the biggest flaw being that Keys cherry-picked the countries he used to support his hypothesis.
According to DiNicolantonio, Dahl did virtually the same thing as he chose five populations from which he would draw a linear line from high blood pressure to salt intake. DiNicolantonio commented:18
“I don’t know what was in the water in the 1950s, but these doctors seemed to pick just five or six populations that fit their hypothesis, plot it out and show the association basically finding what they wanted to find.”
DiNicolantonio continued by describing the 1988 Intersalt study19 in which 52 populations were evaluated for the relationship between urinary electrolyte excretion and blood pressure measurements. Included in the 52 populations were four primitive cultures that did not consume salt.
An analysis of the data showed that when the four tribal populations are included in the total, the overall results show that salt reduction can help lower blood pressure. However, it is important to note that while those populations did not eat salt, they had a diet with high levels of potassium and magnesium. The people group also exercised more, drank no alcohol and ate no foods with processed sugar.
When that group was removed from the data, it demonstrated that the lower levels of salt did not have a positive effect on blood pressure. One of the reasons this may happen is because when salt is cut from the body, insulin resistance rises.
The combination of Dahl’s study and the DASH study lay the blame for high blood pressure, diabetes and kidney disease on salt. DiNicolantonio commented on the relationship between the study funding sources and the results:20
“When you look at the data and look at studies that didn’t have any conflicts with the food industry … There was one systematic review published a few years ago and it literally showed the opposite results.
The studies that didn’t have any conflicts, basically 80% showed that sugar is associated with obesity and gaining weight. And of course 80% of the studies that had conflicts with the industry showed exactly the opposite, which literally goes to show you that absolutely conflicts with the sugar industry and food industry can affect scientific results. That’s what was going on here.”
Conditions That Require Greater Attention to Sodium Levels
One of the best ways I have found to affect my mitochondrial health is through a cyclical ketogenic diet. When some people first begin this switch to ketosis, they can develop something called “keto flu.” This is often a transitory combination of symptoms that include nausea, fatigue and headaches.21
DiNicolantonio describes the process of how going into ketosis can deplete your body of salt, and thus result in some of these symptoms. He explains that your salt levels directly control levels of magnesium and calcium.22
As carbohydrates are cut from the diet, it reduces the amount of insulin in the body, raises glucagon and produces negatively charged ketone bodies. Each of these processes play a role in lowering sodium levels. DiNicolantonio also points out that there are certain subpopulations of people who are more salt sensitive, such as those with:
- High aldosterone levels — This hormone helps the body retain salt by reducing the amount excreted in the kidneys.23 At the same time it causes the body to remove more magnesium.24 This can happen with a benign tumor-secreting aldosterone.
- Cushing’s syndrome — In this disorder, your body makes too much cortisol. This can mimic the actions of aldosterone and cause the body to keep too much sodium and excrete more potassium.25
- Liddle’s Syndrome — In this rare condition people retain too much salt.26
A healthy body has a “salt thermostat”27 that helps control how much salt you should be eating. It basically is about listening to your own salt cravings. However, as DiNicolantonio describes, there are health conditions that contribute to poor sodium absorption or sodium loss. Those include:
- Bowel diseases — People with ulcerative colitis, celiac disease and irritable bowel syndrome do not absorb salt well. Individuals who have had surgical intervention in their gut may also have poor salt absorption. This could include those who have had bariatric surgery or had part of their intestines removed from cancer.
- Adrenal insufficiency — This is also called Addison’s disease and happens when the adrenal glands do not make enough cortisol.28 DiNicolantonio spoke of a paper published in JAMA in the 1940s describing a child who was eating a lot of salt to the point where the parents hospitalized the child. The child ended up dying a few days later from salt loss. People with adrenal insufficiency do not absorb sodium well.
- Hypothyroidism — Thyroid hormones help control metabolism and the kidneys’ ability to resorb salt.29 People with some type of thyroid dysfunction may need more salt.
- Sleep apnea — People with sleep apnea may be losing twice the amount of salt at night, which is why they’re often up during the night to urinate. The interruption in breathing can cause blood to enter the thorax, which increases central blood pressure. This tricks the body into thinking there is an overload of salt and causes the kidneys to excrete more salt and thus more urine during the night.
- Kidney diseases — Individuals with polycystic kidney disease, glomerulonephritis and interstitial damage to the tubules can negatively affect salt loss, leaving higher levels of sodium in the body.
Low Sodium Level Impacts Exercise Performance
DiNicolantonio calls salt “the sixth factor in fitness.”30 He described how Ancel Keys discovered the benefits of salt for individuals who exercise. In the 1940s Keys demonstrated that individuals who work out in the heat without adequate amounts of salt have a 10-fold increase in the potential risk of heat stroke.
As people are looking for ways to improve blood circulation, DiNicolantonio believes that taking a bit of salt before exercise is one of the best ways to improve performance and reduce the risk of dehydration. Before working out he takes a half-teaspoon of salt with enough lemon juice to cover the taste of the salt and 2 ounces of water. He uses this approximately 20 minutes before working out.
The benefits are that you immediately begin increasing blood volume, circulation and reducing heart rate. People who have adequate sodium levels also release more heat because salt is a good vasodilator and allows heat to escape the body. As the heat dissipates during exercise it reduces your core body temperature.
Overtraining syndrome is a challenge faced by many athletes. The literature describes it as a “maladapted response to excessive exercise without adequate rest, resulting in perturbations of multiple body systems coupled with mood changes.”31 DiNicolantonio describes the effect salt has on overtraining syndrome:32
“Overtraining syndrome is literally salt deficiency in the tissues. When your muscles are just losing salt it’s why you get muscle spasms, and twitches and if you just add salt back to the diet you can completely eliminate overtraining syndrome.”
Consider Your Salt Intake
As DiNicolantonio points out, our ancestors ate much more salt than we do, potentially up to 10 times more than we consume today.33 From a historical perspective it’s important to note that society did not suffer from the chronic diseases that are also common today. He believes that the rise in high blood pressure, diabetes and obesity parallels lower salt diets and may have been a contributor to the development of these diseases.
In his research DiNicolantonio finds that the average American consumes about 3,400 milligrams of sodium each day. He does not believe that a person with healthy kidneys can consume too much salt, since the kidneys will flush out the excess amount.
It’s crucial to consider the source of your sodium since sea salt from the modern oceans contains modern-day pollutants,34 like plastics and traces of heavy metals when compared to Himalayan Sea salt or Redmond salt from ancient oceans.
DiNicolantonio also points out that it’s important to get enough salt each day because a sodium deficiency can reduce vitamin C absorption, which indirectly affects bone health and strength due to the resultant vitamin C deficiency.35 The chloride in salt is also a necessary part of hydrochloric acid, which is a component of how food is broken down in the stomach.
One factor in lower amounts of hydrochloric acid in the gut, which contributes to acid reflux and gastroesophageal reflux disease, is there may not be enough salt to produce enough hydrochloric acid. Simply normalizing your salt intake is a classic example of how simple strategies have a considerable impact on health and wellness.
New York pulmonologist Dr. Pierre Kory, an unapologetic champion of evidence-based medicine, has had remarkable success treating patients with ivermectin and other therapies during the pandemic. His efforts to get the word out on this treatment protocol as part of the Front Line COVID-19 Critical Care Working Group (FLCCC) have largely been stifled by censorship, ridicule and colleagues — brainwashed by the official narrative — unwilling to accept the science.
Kory spoke with Dr. Chris Martenson, host of the Peak Prosperity podcast, about his incredible experiences over the last nearly two years.1 On December 8, 2020, Kory testified to the Senate Committee on Homeland Security and Governmental Affairs, which held a hearing on “Early Outpatient Treatment: An Essential Part of a COVID-19 Solution.”
He called on the NIH, CDC and FDA to review the expansive data on ivermectin to prevent COVID-19, keep those with early symptoms from progressing and help critically ill patients recover.2,3 As he told Martenson, due to their promising results, he believed early on that “the pandemic has been solved,” until he realized that those in power weren’t open to hearing what he had to say.
Despite his impassioned pleas and astonishing science to back them up, the treatment not only was ignored by the Senate committee but promptly eviscerated.4 Now, he feels his colleagues in the health care field are living in one of two worlds — by either not following the data or putting patients first because they’re afraid of losing their job or status, or by risking everything to put patients first. He’s become estranged from many colleagues who he says “don’t get it.”
There Is Treatment Available for Viruses
Kory’s eyes have been opened to the reality that many people only hear or believe what public health officials tell them, whether it’s because they’re overworked and don’t have time to delve into the real data or because they’re following with blind trust. Many of Kory’s colleagues have gone along with those they believe to be authoritative experts, even when their guidance defies logic and commonsense. Kory’s trust in the “experts,” however, started to erode the more that he learned.
One of Kory’s role models is Dr. Paul Marik, a critical care doctor at Sentara Norfolk General Hospital in East Virginia, who is renowned for his work in creating the “Marik Cocktail,” which significantly reduces death rates from sepsis using inexpensive, safe, generic medications.5
Marik was one of a small group of critical care physicians who formed FLCCC, which developed a highly effective COVID-19 treatment protocol known as MATH+.6 Marik is so in tune with science that if he reads a new study and has questions, he’ll contact the first author on the paper to get direct answers.
Right off the bat, the MATH+ protocol led to high survival rates. Out of more than 100 hospitalized COVID-19 patients treated with the MATH+ protocol by mid-April 2020, only two died. Both were in their 80s and had advanced chronic medical conditions.7
After several tweaks and updates, the prophylaxis and early outpatient treatment protocol is now known as I-MASK+8 while the hospital treatment has been renamed I-MATH+,9 due to the addition of ivermectin.
Kory is now a public face of FLCCC, and he’s forged a global network of colleagues who are willing to adapt to new information in any way they can to help patients. One of Kory’s biggest revelations involved the treatment of viruses — specifically, the fact that there are dozens of treatment options available, about 90% of which are repurposed, cost pennies and are readily available:10
“I went into this pandemic believing what I’ve been taught my whole career, which is that there is no specific antiviral therapy … I mean, you get a cold, you just rest … and now here I am 18 months later — oh my gosh — there are literally two dozen compounds and now we have trial evidence showing pretty profound large magnitude benefits, either in the duration of symptoms, the duration of viral transmission, hospitalization and death.
We have a number of molecules that actually reduce mortality in what’s turned out to be a deadly viral disease. This isn’t the common cold, we’re clear on that.
I went from, there’s nothing to do for a virus to now, anytime I have a cold going forward, or any of my children, or any other virus that comes at us, we already have a whole armory of stuff that we can employ. And that data for those — which are best, which should be employed — is only going to increase.”
Giving Patients Agency Over Their Own Health
Marteson said that, since learning about accessible treatment options, “I feel like I have agency in my own health that I didn’t have before.”11 Kory mentions natural options like curcumin and nigella sativa, or black cumin, which he would have laughed off years ago, but now realizes they have multiple mechanisms by which they fight viruses:12
“Reading about something like curcumin or nigella sativa, which if someone told me a year ago to take something like nigella sativa — black cumin seed — it would save your life in a viral disease, I would have literally burst out laughing … but when you look, there’s literally 10 years of lots of little trials and studies that have evaluated and defined multiple mechanisms of black cumin seed — immunomodulatory, anti-inflammatory, antiviral.
So you have all of these building blocks, and then you have this trial from Pakistan — large randomized controlled trial with really large magnitude benefits — of literally nigella sativa and honey. And then you find out about honey. Honey also has pleotropic properties.”
Kory is driven to share what he’s learned with as many people as possible, because he believes that everyone should feel empowered to stay healthy, similar to what I have long advised — to take control of your health. He told Marteson:13
“It’s so satisfying because now we have agency, and so many people have agency by learning this knowledge of things that are readily available, cheap, don’t need a prescription, that you can actually treat yourself with very safe compounds. Not only is that agency so satisfying, but boy does it seem critical for the future. Is this going to be the last viral pandemic?”
His index case with ivermectin — the first person with COVID-19 whom he treated with the drug — is also etched in his memory. The patient — a “slightly older, slightly overweight” woman — was two weeks into COVID-19 and still having fevers and night sweats, so still quite sick. He treated her with ivermectin and she woke up in the morning feeling great:14
“Literally I saw what could only be described as a phenomenal response to a medication. So when we talk about data that we use, I’m sorry but I was sold right there on the first dose. First patient, first dose. And then I had repeated experiences.”
COVID-19 Is Highly Treatable
Fear has dominated the pandemic, but both Martenson and Kory say there’s no need to walk around in fear. As a lung and ICU expert, Kory is a master at treating acute illnesses which, he says, “is all about trajectories.” “When we make rounds on patients, we see them every day, we’re following their course … in an ICU, I have to be very knowledgeable about their minute-to-minute, or sometimes hour-to-hour trajectory,” he said.15
He teaches medicine also, and he teaches his trainees to study trajectories in their patients. When the trajectory worsens, especially in critical illness, therapies must be instituted but, he says, when “I see a trajectory on the improvement, I always say just stand back. They’re getting better, they’re going to continue to get better …”16
In the case of his index patient with ivermectin, she was on a steady trajectory, but it rapidly improved upon administration of ivermectin — a pattern he sees regularly with the drug. The ability to get a sense of this pattern recognition is what makes the difference between an expert and nonexpert in critical care medicine, Kory says.
“The longer you’re in medicine, the better you get at that and you can see which medicines are working.” In this case, ivermectin is one that quickly stood out from the rest. Especially if you’re an expert at trajectories, patterns and diseases, as Kory is, “you can figure things out much quicker than a massive, multicentered, double-blinded, randomized controlled trial.”17
If there were one thing that Kory could share, it’s that he wants everyone to know that COVID-19 is a highly treatable disease:18
“I want everybody to know how treatable this is … I’m not that worried about it for me, my friends, my family, my colleagues. I’m not worried about it for those who follow the FLCCC and our protocols because we know that they’re effective.
And I just hope that umbrella of reassurance and protection, which is to say there are effective treatments which will save your life and prevent the need for hospitalization, I just hope that number grows. But me personally, I’m not that bothered by COVID. As you know, I actually got COVID. It was a relatively mild case and so I also have natural immunity in my camp.”
Early treatment, however, is essential. One of his friends became ill with COVID-19 and made the mistake of thinking he had a cold. He didn’t contact Kory until he’d been sick for seven or eight days and by that time, he said, “I had to pull out all the stops for him. I really had to use every tool in my arsenal to keep him out of the hospital.” So if you have COVID-19, the sooner you implement the treatment protocol, the better.
There’s a War Against Truth
The successful treatment of COVID-19 using ivermectin and other therapies is being actively suppressed. Few, for instance, have heard about the astonishing success in Uttar Pradesh, India, which embraced large-scale prophylactic and therapeutic use of ivermectin for COVID-19 patients, close contacts of patients and health care workers.19
They’ve since had a COVID-19 positivity rate of almost zero, marking a major public health achievement that Kory believes should be a model for the world. Even the World Health Organization praised Uttar Pradesh for their excellent public health measures, which included sending people out to villages to conduct rapid COVID-19 tests and, if positive, treat patients and close contacts with ivermectin.
WHO, however, did not mention ivermectin as part of Uttar Pradesh’s success story.20 Kory now calls the FLCCC an “army,” because “they’re actively fighting a war”:21
“They’re challenging the pharmacists. They’re talking to their doctors. They’re writing to pharmacy boards … I don’t think war is an overstatement here. There’s a war on truth. There’s a war on free discourse and sharing of opinions. One of the catastrophic things is the way they branded misinformation on the level of a felony. Someone who has an opinion that differs from the agency’s is automatically medical misinformation.
It’s treated as though it’s a scourge of society that needs to be extinguished. I think people are fighting back against that. It’s nice to hear the army and the tribe is growing and most important is, I think we’re helping people. We’re arming people with agency and the ability to navigate a pretty confusing world.”
FLCCC’s I-MASK+ protocol can be downloaded in full,22 giving you step-by-step instructions on how to prevent and treat the early symptoms of COVID-19. FLCCC also has protocols for at-home prevention and early treatment, called I-MASS, which involves ivermectin, vitamin D3, a multivitamin and a digital thermometer to watch your body temperature in the prevention phase and ivermectin, melatonin, aspirin and antiseptic mouthwash for early at-home treatment.
Household or close contacts of COVID-19 patients may take ivermectin (18 milligrams, then repeat the dose in 48 hours) for post-exposure prevention.23 FLCCC also has a management protocol — I-RECOVER24 — for long-haul COVID-19 syndrome. The protocols are translated into 23 different languages to provide widespread, free access to this lifesaving information, including how to get ivermectin.25
FLCCC remains hopeful that ivermectin will be formally adopted into national or international COVID-19 treatment guidelines in the near future.
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