Benjamin Fulford 5-16-22… “Destroy KM or face nuclear war Russia and China tell Pentagon” (RMN & SITS links)

I’m posting the RMN and SITS links for this. It’s all laid out and ready to view. Enjoy the show(s), and Hold the Light for the planet.

https://www.rumormillnews.com/cgi-bin/forum.cgi?read=199495

https://stillnessinthestorm.com/2022/05/benjamin-fulford-may-16th-2022-destroy-km-or-face-nuclear-war-russia-and-china-tell-pentagon/

[Kp note: I’m being gentle on my Self, and not struggling anymore with the BFs.]

[Here’s the BF page link.]

Food Plants on Fire

We’re living in an unprecedented time when strange happenings continue to occur in quick succession. In March 2021, a massive container ship became wedged across the Suez Canal in Egypt — blocking “an artery of world trade,” triggering a rise in oil prices and leading to fallout that affected shipping around the globe.1

Now, war has disrupted supplies further, driving up fertilizer prices and, in turn, food costs. Meanwhile, Bill Gates has been buying up U.S. farmland at a frenzied pace and owns more farmland than any other private farmer in the country.2 Leaders around the world have warned that, due to the war in Ukraine — which is considered the world’s bread basket — food shortages are coming.

On top of that, the Really Graceful video posted above points out, cases of bird flu have been reported in the U.S., with millions of poultry killed off by farmers as a result. “All of these incidents have driven up the price of items at your grocery store,”3 the video notes, but there’s yet another series of events that is somehow even stranger — a rash of fires at U.S. food processing plants.

Could this all be coincidence, driving up food prices to record highs and causing food shortages, or is something more sinister going on?

Fires and Accidents at Food Processing Plants: Coincidence?

In the whole of 2019, there were only two reported fires at U.S. food processing plants. From January 2021 to April 21, 2022, at least 20 were reported — a sizable jump — and they seem to be accelerating in recent weeks.4 Here’s a timeline of some of the events:

August 9, 2019 — A fire destroyed part of the Tyson Foods beef plant in Holcomb, Kansas.5

January 12, 2021 — A fire destroyed the Deli Star meat plant in Fayetteville, Illinois.6 In fighting the blaze, firefighters used most of the water in the town’s water towers, leading to a boil order for residents until the water could be replenished.

January 21, 2021 — The Washington Potato Company plant was declared a total loss after a fire started in the plant’s dehydrator.7

July 25, 2021 — A three-alarm fire occurred at a Kellogg plant in Memphis, Tennessee, drawing 170 emergency personnel to the scene.8

August 24, 2021 — Severe damage was reported following a fire at Patak Meat Processing facility in Cobb County, Georgia,9 leading to a temporary closure.

September 12, 2021 — A five-alarm fire broke out at JBS USA’s beef processing plant in Grand Island, Nebraska.10 The plant slaughters about 5% of U.S. cattle. “This year, processing capacity has already been squeezed by COVID disruptions and labor availability and the industry can ill afford losing a big processing plant like this,” Steiner Consulting told Reuters at the time.11

November 29, 2021 — A fire broke out at Maid Rite Steak Company, a meat processing plant in Scott, Pennsylvania.12

December 12, 2021 — West Side food processing plant was left with smoke damage estimated at over $100,000 due to a fire that broke out. No one was working at the plant at the time of the fire.13

January 2, 2022 — A fire at Van Drunen Farms Tuthill freeze-drying plant in Momence, Illinois, suffered extensive damage from a fire, with a company official describing it as a “total loss.”14

January 14, 2022 — An explosion and fire occurred at the Cargill-Nutrena feed mill in Lecompte, Louisiana, burning for 12 hours.15

February 3, 2022 — Fire swept through Wisconsin River Meats in Mauston, Wisconsin, causing a near total loss.16

February 17, 2022 — A fire broke out at the Louis Dreyfus Co. (LDC) in Claypool, Indiana.17 LDC is the largest soybean processing and biodiesel plant in the U.S.

February 22, 2022 — A boiler explosion triggered a fire at Shearer’s Foods near Hermiston, Oregon. Company officials estimated it would take 15 to 18 months to restart production.18 The plant made snacks including potato chips, tortillas, whole grain chips, cheese curls/puffs, popcorn, pork rinds, rice crisps, wafers, cookies, and both sweet and savory biscuits.

March 13, 2022 — A Hot Pockets plant in Jonesboro, Arkansas, was shut down after a fire started inside a production line cooler.19

March 16, 2022 — A massive fire at a Walmart fulfillment center in Plainfield, Indiana, caused the closure of the facility. In April, the company announced it would not be reopening the facility, affecting the jobs of 1,132 employees.20 The center stored food, clothes and cardboard.21

March 28, 2022 — A fire at Maricopa Food Pantry in Maricopa, Arizona, leading to the destruction of more than 50,000 pounds of food.22

March 31, 2022 — Rio Fresh, an onion warehouse facility in south Texas, was damaged by a structure fire.23

April 11, 2022 — A fire broke out at East Conway Beef & Pork in Conway, New Hampshire, destroying the building and killing two cows.24

April 13, 2022 — A plane crashed into the Gem State processing facility in Heyburn, Idaho.25 The plant made dehydrated potato flakes, flours, dices, slices and shreds.26

April 13, 2022 — A four-alarm fire occurred at Taylor Farms in Salinas, California, drawing nearly 100 firefighters from 22 fire units. The facility, which makes bagged salads and chopped fresh vegetable kits,27 was in the process of restarting operations after being closed for the winter.28

April 18, 2022 — The headquarters of Azure Standard in Dufur, Oregon, was destroyed in a fire. Azure Standard the largest independent distributor of organic and health foods in the U.S.29

April 30 2022 — A soybean processing tank caught fire at Perdue Farms in Chesapeake, Virginia.30

What’s Behind Rising Food Prices?

People are beginning to take notice of these seemingly random fires and accidents that are occurring with increasing frequency at food processing plants across the U.S. As noted by Really Graceful:31

“We’ve got all these factors at play to cause food shortages and increased prices. But are we witnessing total happenstance and coincidence or is it intentional? Are they trying to take down our food supply? Are they trying to sabotage our supply chain? And by ‘they,’ who do we mean? The enemy from within or an enemy of a foreign variety?”

There are no concrete answers to these questions, unfortunately, but we’re witnessing what appears to be the perfect storm for sky-high food prices and food scarcity. The global food price index hit its highest recorded level in March 2022, rising 12.6% in a single month.32 On average, food prices were one-third higher than in March 2021. In the U.S., food prices rose 9% in 2021, and are predicted to rise another 4.5% to 5% in the next 12 months.33

The Russia-Ukraine conflict is certainly not helping. As mentioned, Ukraine is known as “the bread basket” of Europe, responsible for producing and exporting 12% of all food calories traded on the international market. Russia is also a major exporter of food and, together with Ukraine, the two countries account for nearly 30% of global wheat exports, nearly 20% of the world’s corn and more than 80% of the sunflower oil.34

Still, the Ukraine conflict is not entirely to blame. Price inflation was already ramping up well before Russia went into Ukraine, thanks to the uncontrolled printing of fiat currencies that occurred in response to the COVID pandemic. Governments’ COVID response have also wreaked havoc with global supply chains, causing disruptions that continue to this day.

The climate has also been uncooperative, causing poor harvests around the world. China, for example, has reported it expects the lowest harvest yields in history this year, thanks to serious flooding of its farmland in the fall of 2021.35

Are We Entering Phase 2 of The Great Reset Plan?

By now, you may have heard about the World Economic Forum’s (WEF) Great Reset and their plan for you to “own nothing and be happy” as part of WEF’s 2030 agenda.36 In the first quarter of 2021, 15% of U.S. homes sold were purchased by corporate investors37 — not families looking to achieve their American dream.

While they’re competing with middle-class Americans for the homes, the average American has virtually no chance of winning a home over an investment firm, which may pay 20% to 50% over asking price,38 in cash, sometimes scooping up entire neighborhoods at once so they can turn them into rentals.39 It appears we’re quickly entering an era where home ownership is becoming out of reach for many — necessitating renting instead of owning, a first step to “owning nothing.”

World war, however, is Phase 2 of The Great Reset plan, which includes the destruction of supply chains, the energy sector, food supply and workforce, to create dependency on government, which in turn will be taken over by private interests and central banks through the collapse of the global economy. An anonymous correspondent recently wrote about this on WinterOak.org:40

“Welcome to the second phase of the Great Reset: war. While the pandemic acclimatized the world to lockdowns, normalized the acceptance of experimental medications, precipitated the greatest transfer of wealth to corporations by decimating SMEs [small and medium-sized businesses] and adjusted the muscle memory of workforce operations in preparation for a cybernetic future, an additional vector was required to accelerate the economic collapse before nations can ‘Build Back Better.’”

The article presents “several ways in which the current conflict between Russia and Ukraine is the next catalyst for the World Economic Forum’s Great Reset agenda, facilitated by an interconnected web of global stakeholders and a diffuse network of public-private partnerships.”

Disruption to supply chains fit right into this plan, while food shortages, driven by the many factors discussed and, perhaps, orchestrated attacks on food plants, will accelerate the acceptance of synthetic foods, such as lab-grown meat, which has also been championed by Great Reset front men like Bill Gates.

Of course, it’s possible that Gates buying up farmland, The Great Reset’s push to build a nation of renters, world leaders warning of food shortages, a war and, now, an unexplained jump and apparent acceleration in fires at food plants could all be just coincidence — or could it? What do you think?

Did Pfizer Commit Huge Fraud in Its COVID Vaccine Research?

In November 2021, Brook Jackson, a whistleblower who worked on Pfizer’s Phase 3 COVID jab trial in the fall of 2020, warned she’d seen evidence of fraud in the trial.

Data were falsified, patients were unblinded, the company hired poorly trained people to administer the injections, and follow-up on reported side effects lagged way behind. The revelation was published in The British Medical Journal. In his November 2, 2021, report, investigative journalist Paul Thacker wrote:1

“Revelations of poor practices at a contract research company helping to carry out Pfizer’s pivotal COVID-19 vaccine trial raise questions about data integrity and regulatory oversight …

[F]or researchers who were testing Pfizer’s vaccine at several sites in Texas during that autumn, speed may have come at the cost of data integrity and patient safety … Staff who conducted quality control checks were overwhelmed by the volume of problems they were finding.”

Jackson, a former regional director of Ventavia Research Group, a research organization charged with testing Pfizer’s COVID jab at several sites in Texas, repeatedly “informed her superiors of poor laboratory management, patient safety concerns and data integrity issues,” Thacker wrote.

When her concerns were ignored, she finally called the U.S. Food and Drug Administration and filed a complaint via email. Jackson was fired later that day after just two weeks on the job. According to her separation letter, management decided she was “not a good fit” for the company after all.

She provided The BMJ with “dozens of internal company documents, photos, audio recordings and emails” proving her concerns were valid, and according to Jackson, this was the first time she’d ever been fired in her 20-year career as a clinical research coordinator.

BMJ Report Censored

Disturbingly, social media actually censored this BMJ article and published pure falsehoods in an effort to “debunk” it. Mind you, the BMJ is one of the oldest and most respected peer-reviewed medical journals in the world! The Facebook “fact check” was done by Lead Stories, a Facebook contractor, which claimed the BMJ “did NOT reveal disqualifying and ignored reports of flaws in Pfizer’s” trials.2

In response, The BMJ slammed the fact check, calling it “inaccurate, incompetent and irresponsible.”3,4,5 In an open letter6 addressed to Facebook’s Mark Zuckerberg, The BMJ urged Zuckerberg to “act swiftly” to correct the erroneous fact check, review the processes that allowed it to occur in the first place, and “generally to reconsider your investment in and approach to fact checking overall.” As noted by The BMJ in its letter, the Lead Stories’ fact check:7

  • Inaccurately referred to The BMJ as a “news blog”
  • Failed to specify any assertions of fact that The BMJ article got wrong
  • Published the fact check on the Lead Stories’ website under a URL that contains the phrase “hoax-alert”

Pfizer Trial Data Raises Suspicions of Fraud

Now, with the release of Pfizer trial data8 — which they tried to withhold for 75 years — internet sleuths are finding additional problems suggestive of fraud and data manipulation. May 9, 2022, a Twitter user named Jikkyleaks posted a series of tweets questioning data from Pfizer trial sites 1231 and 4444.9

Trial site 1231, located in Argentina, somehow managed to recruit 10% of the total trial participants, 4,501 in all, and they did so in just three weeks, and without a contract research organization (CRO). CROs like the Ventavia Research Group, which Jackson worked for, provide clinical trial management services. The lead investigator for trial site 1231 is Dr. Fernando Polack,10 who also happens to be:11

  • A consultant for the U.S. Food and Drug Administration’s Vaccines and Related Biological Products Advisory Committee (RBPAC) since 2017
  • A current adjunct professor at Vanderbilt University in Tennessee
  • An investigator for Fundación Infant,12 which is funded by the Bill & Melinda Gates foundation13
  • The first author of Pfizer’s paper,14 “Safety and Efficacy of the BNT162b2 mRNA COVID-19 Vaccine,” published at the end of December 2021

As noted by Jikkyleaks, Polack “is literally the busiest doctor on the planet,” because in addition to all those roles, he also managed to single-handedly enroll 4,500 patients in three weeks, which entails filling out some 250 pages of case report forms (CRFs) for each patient. That’s about 1,125,000 pages total. (CRFs are documents used in clinical research to record standardized data from each patient, including adverse events.)

This recruitment also took place seven days a week, which is another red flag. “Weekend recruitment for a clinical trial would be odd. Staff are needed to fill out that many record forms (CRFs) and there are potential risks to the trial, so you need medical staff. It would be highly unusual,” Jikkyleaks notes.

Is Polack just a super-humanly efficient trial investigator, or could this be evidence of fraud? As noted by Steve Kirsch in the featured video and an accompanying Substack article,15 Polack is the coordinator for a network of 26 hospitals in Argentina, so perhaps it’s possible he could have recruited 57 patients per week per hospital, but it seems highly unlikely.

Questions Surround Site 4444 Data

Now, “site 4444” does not exist. It’s actually the same as site 1231. It appears site 1231 held a second enrollment session, and these were for some reason given the designation of 4444. The 4444 trial site data raise another red flag.

Site 4444 (the second enrollment session for site 1231) supposedly enrolled 1,275 patients in a single week, from September 22 through 27, 2020, and the suspicious thing about that — aside from the speed — is the fact that this was the last week that recruitment could take place to meet the data cutoff for the FDA meeting in December 2020. Jikkyleads writes:16

“My guess: they needed enough numbers of ‘positive PCR tests’ in the placebo group to show a difference between groups for that VRBPAC meeting on the 10th Dec, and they didn’t have them. So, site 4444 appeared and gave them their ‘perfect’ result. Bravo.”

cumulative incidence

Kirsch notes:17

“Was there fraud in the Pfizer trial? Without a doubt. The story of Maddie de Garay is a clear case of that. Brook Jackson has evidence of fraud; she has 17 lawyers working for her. If there wasn’t fraud, these lawyers wouldn’t be wasting their time.

This new data on Site 1231/4444 looks suspicious to me. It looks too good to be true. But we can’t make the call without more information. Undoubtedly, the mainstream media will not look into this, Pfizer will remain silent, and Polack will be unreachable for comment. The lack of transparency should be troubling to everyone. That is the one thing we can say for sure.”

Pfizer Documents Reveal COVID Jab Dangers


Among the tens of thousands of Pfizer documents released by the FDA so far, we now also have clear evidence of harm. For nurse educator John Campbell, featured in the video above, these documents appear to have served as a “red pill,”18 waking him up to the possibility that the jabs may indeed be far more dangerous than anyone expected, including himself.

In the video, Campbell reviews the documents listed as “5.3.6. Postmarketing Experience,” which were originally marked “confidential.” They reveal that, cumulatively, through February 28, 2021, Pfizer received 42,086 adverse event reports, including 1,223 deaths.

To have 1,223 fatalities and 42,086 reports of injury in the first three months is a significant safety signal, especially when you consider that the 1976 swine flu vaccine was pulled after only 25 deaths.

As noted by Campbell, “It would have been good to know about this at the time, wouldn’t it?” referring to the rollout of the jabs. Campbell has been fairly consistent in his support of the “safe and effective” vaccine narrative, but “This has just destroyed trust in authority,” he said.

158,000 Recorded Side Effects — A World Record?

The first really large tranche of more than 10,000 Pfizer documents was released March 1, 2022. (You can find them all on PHMPT.org.19) In this batch were no less than nine single-space pages of “adverse events of special interest,” listed in alphabetical order20 — 158,000 in all!

To see the first page, click the link below. The first side effect on this shockingly exhaustive list is a rare condition known as 1p36 deletion syndrome. This condition, caused by the deletion of DNA in chromosome 1p36, results in developmental delays, severe intellectual disability, seizures, vision problems, hearing loss, breathing problems, brain anomalies, congenital heart defects, cardiomyopathy, renal anomalies, genital malformation, metabolic problems and more.21,22

Life expectancy depends on the amount of DNA that has been deleted. This, at bare minimum, sounds like something a pregnant woman might want to know before she gets the shot.

pfizer list release

>>>>> Click here <<<<<

CRF Anomalies Raise Questions of Fraud

After reviewing some of the released CRFs in the March 1 tranche, investigative journalist Sonia Elijah also discovered several problems, including the following:23

Patients entered into the “healthy population” group who were far from healthy — For example, one such “healthy” participant was a Type 2 diabetic with angina, a cardiac stent and a history of heart attack.

Serious adverse event (SAE) numbers were left blank — Ventavia site No. 1085 has a particularly large number of missing SAE numbers.

Missing barcodes for samples collected — Without those barcodes, you can’t match the sample to the participant.

Suspicious-looking SAE start and end dates — For example, the so-called “healthy” diabetic suffered a “serious” heart attack October 27, 2020. The “end” date is listed as October 28, the next day, which is odd because it was recorded as serious enough to require hospitalization.

Also, on that same day, October 28, the patient was diagnosed with pneumonia, so likely remained hospitalized. “This anomaly raises doubt as to the accuracy of these recorded dates, potentially violating ALOCA-C clinical site documentation guidelines for clinical trials,” Elijah writes.

Unblinded teams were responsible for reviewing adverse event reports for signs of COVID cases, and to review severe COVID cases — Yet in some cases they appear to have dismissed the possibility of an event being COVID-related, such as pneumonia. This despite the fact that Pfizer’s protocol (section 8.2.4) lists “enhanced COVID-19” (i.e., antibody dependent enhancement) as a potential side effect to be on the lookout for. As noted by Elijah:

“Inadvertently, this could have led to bias, as the unblinded teams would have been aware which participants were assigned the placebo and those who received the vaccine. They might have been under pressure by the sponsor for the trial to go a certain way and for events like ‘COVID Pneumonia’ to be classified simply as pneumonia.”

Impossible dating — The diabetic who suffered a heart attack followed by pneumonia (which may have been unacknowledged COVID pneumonia) died, and the date of death is listed as the day before the patient supposedly went for a “COVID ill” visit.

Clearly, it’s impossible for a dead person to attend a medical visit, so something is wrong here. The clinical investigator note states: “There cannot be a date later than date of death. Please remove data from the COVID illness visit and add cough and shortness of breath as AEs (adverse events).” “What kind of pressure was being exerted here?” Elijah asks.

Second dose administered outside the three-week protocol window.

Observation period appears to have been an automatic entry — According to the protocol, each participant was to be observed by staff for a minimum of 30 minutes.

A majority of the CRFs state 30 minutes, which raises the question: Were participants observed for adequate amounts of time, or did they simply put down “30 minutes” as an automatic entry? Why is there so little variety in the observation times? If participants were not adequately observed, their safety was put at risk, which was one of Jackson’s concerns.

Adverse events listed as “not serious” despite extended hospital stay — In one case, the participant fell and suffered facial lacerations the day after the second dose and was hospitalized for 26 days, yet the fall was not reported as serious.

Other anomalies in this particular case include listing the fall as being caused by a “fall” unrelated to the study treatment, and the facial laceration being the result of “hypotension” (low blood pressure). The SAE number is also missing for the facial lacerations.

Elijah writes, “Doubts can be raised over the credibility of this information given the fall and facial lacerations were intrinsically related. So, if facial lacerations were due to ‘hypotension’ then the fall should be due to that too.” Might low blood pressure be an effect of the experimental shot? Possibly. Especially when you consider the patient fell the day after being given the second dose.

Even more suspicious: the causality for the fall was recorded as “related” (to the treatment) on the serious adverse event form, but listed as “not related” on the adverse event CRF. A note states, “Please confirm correct causality.”

Dismissing brand new health problems as unrelated to the treatment — For example, in one case, a female participant with no medical history of impaired kidney function was diagnosed with kidney stones and severe hypokalemia, requiring hospitalization, one month after her second dose. Yet despite her having no history of kidney problems, both events were dismissed as “not related” to the study treatment and no further investigation was done.

In closing, Elijah wrote:24

“All the evidence gleaned over a limited time appears to back up whistleblower Jackson’s claims of poor trial site data management and raises questions as to how Ventavia conducted the Pfizer clinical trials.

The errors and anomalies in the CRFs also allude to her claims that the clinical research associates were not trained adequately, with many having had no prior clinical experience history. If such egregious findings are true at these sites, could they manifest at other trial sites around North America and beyond?”

Can You Trust Pfizer?

Pfizer, which was quickly given emergency use authorization (EUA) for its COVID-19 mRNA gene therapy shot, has a long list of criminal verdicts against it:

In 2002, Pfizer and two subsidiaries paid $49 million to settle civil claims that it had failed to report best prices for its drug Lipitor, as is required under the Medicaid Drug Rebate Statute.25

In 2004, a Pfizer subsidiary Warner-Lambert pleaded guilty and paid more than $430 million to settle criminal charges and civil liability from fraudulent marketing practices.26

In 2007, another subsidiary was found guilty of paying out kickbacks for formulary placement of its drugs and had to pay a fine of $34 million.27

Two years later, in 2009, Pfizer was found guilty of health care fraud and ordered to pay the largest penalty ever for this kind of offense.28 When announcing the record penalty of $2.3 billion against the drug giant, the U.S. Department of Justice said one of the charges was a felony. The other charges stemmed from false actions and false claims submitted to federal health care programs.

In 2010, the company was again ordered to pay $142 million in damages for fraudulent marketing and promoting the drug Neurontin for unapproved uses.29

Less than 10 years later, in 2018, Pfizer was again caught in an illegal kickback scheme and agreed to pay $23.8 million to resolve claims that it used a foundation as a conduit to pay the copays of Medicare patients taking three of its drugs.30

As noted in the journal Healthcare Policy in 2010,31 “Pfizer has been a ‘habitual offender,’ persistently engaging in illegal and corrupt marketing practices, bribing physicians and suppressing adverse trial results.” The article also highlights the crimes of Johnson & Johnson, another COVID jab maker.

Despite its tarnished history, we’re now expected to trust that everything Pfizer does is above-board. I don’t think so. A company that continues getting caught committing the same crimes over and over again clearly has a deeply established ethical rot within its corporate structure that fines simply have no effect over.

Has Pfizer committed fraud in its COVID jab trials as well? It sure looks that way. Time will tell whether attorneys will have enough for a conviction in the future. If fraud did take place, Pfizer can (and likely will) be held liable for the more than one million injuries its injection has caused in the U.S. alone, and we all look forward to that reckoning.

Two Remarkable Stress Relief Supplements; Take Them Together

This article was previously published June 10, 2019, and has been updated with new information.

You may be familiar with the connection between magnesium, calcium and vitamins K2 and D and how they work in tandem. But are you aware of the crucial link between magnesium and vitamin B6 (pyridoxine)? Individually, magnesium and vitamin B6 are both essential for heart and brain health. Both also play roles in the regulation of your blood sugar level.1,2

When you get insufficient amounts of magnesium from your diet, your body will leach magnesium from your bones, muscles and internal organs, which can lead to osteoporosis, kidney problems and liver damage.

Vitamin B6 can help ameliorate this by escorting magnesium to the cells that need it most, thus ensuring that the magnesium you’re getting, whether from foods or supplements, is being used as efficiently as possible. In so doing, vitamin B6 also helps augment the many benefits of magnesium.

Magnesium-B6 Combo Is Superior for Severe Stress

The importance of magnesium in combination with vitamin B6 was presented in a 2018 study3 in the journal PLOS ONE. Taken together, these two nutrients have been shown to have a complementary effect on stress reduction in animal studies.

In this randomized trial, they evaluated whether the combination of magnesium and B6 would improve perceived stress levels in 264 human subjects who also had low magnesium to start. Healthy adults with a depression anxiety stress scale score above 18 and a serum level of magnesium between 0.45 nanomoles per liter (mmol/L) and 0.85 mmol/L were randomized to receive either:

  1. 300 milligrams (mg) of magnesium in combination with 30 mg of vitamin B6
  2. 300 mg of magnesium only

The primary endpoint was a reduction in stress score from baseline to Week 8. While both treatment groups experienced similar reductions in their stress scores — the magnesium-B6 combo group reporting a 44.9% reduction in perceived stress and the magnesium-only group a 42.4% reduction — a more significant impact was shown in those with severe and/or extremely severe stress.

According to the authors, adults with a stress score at or above 25 had a 24% greater improvement with magnesium-vitamin B6 versus magnesium only at Week 8. Those taking magnesium and B6 in combination also experienced fewer side effects: 12.1% of those taking magnesium-vitamin B6 versus 17.4% of those taking magnesium only experienced some form of adverse event. As noted by the authors:4

“These findings suggest oral Mg supplementation alleviated stress in healthy adults with low magnesemia and the addition of vitamin B6 to Mg was not superior to Mg supplementation alone. With regard to subjects with severe/extremely severe stress, this study provides clinical support for greater benefit of Mg combined with vitamin B6.”

Magnesium and B6 May Ease Premenstrual Syndrome

Magnesium and vitamin B6 are two nutrients commonly recommended for women struggling with premenstrual syndrome. According to a research paper5 published in the Journal of Caring Sciences, magnesium deficiency has been proposed “as one of the factors causing and intensifying premenstrual syndrome symptoms,” and magnesium appears to work because it has a calming effect on the neuromuscular system.

“Vitamin B6 is another proposed treatment for this syndrome,” the paper notes.6 “On the one hand vitamin B6 increases serotonin and dopamine levels and improves premenstrual syndrome symptoms, and on the other, it has an essential role in the synthesis of prostaglandin and fatty acids, which are reduced in etiologies causing premenstrual syndrome.

Moreover, researchers believe that vitamin B6 deficiency decreases dopamine in the kidneys and therefore increase sodium excretion, which in turn causes water accumulation in the body and induces symptoms such as swelling in extremities, edema, and abdominal and chest discomfort. The administration of vitamin B6 can thus decrease these symptoms and improve premenstrual acne.”

To evaluate the effects of these two nutrients on premenstrual syndrome, 126 women diagnosed with premenstrual syndrome, based on American Psychiatric Association criteria, were divided into three groups, which received either 250 mg of magnesium oxide, 250 mg of vitamin B6, or a placebo, taken from the first day of the menstrual cycle until the beginning of the next cycle.

Magnesium and B6 Have Similar Rates of Effectiveness

Overall, magnesium and B6 had similar rates of effectiveness for premenstrual syndrome in this Journal of Caring Sciences study. Mean scores of premenstrual syndrome before and after intervention in the three groups were as follows:

Magnesium Vitamin B6 Placebo
Before intervention 36.89% 36.51% 35.8%
After intervention 22.22% 22.84% 28.41%

As you can see, while the placebo also helped reduce premenstrual syndrome symptoms, magnesium and B6 did so more effectively, and at similar rates. When looking at specific symptoms, B6 and magnesium were found to be the most effective for lowering rates of depression, water retention and anxiety. In conclusion, the authors noted:7

“Considering the importance of premenstrual syndrome and the numerous effects it has on society and the lives of women, health groups should prioritize the diagnosis and treatment of this syndrome. Since there is no definitive etiology and treatment for this syndrome, many researchers have tried to find the best and most effective drug with the least side effects to prevent the occurrence of the syndrome …

The current study was also undertaken with the goal of finding an effective compound with no side effects to reduce the symptoms of this syndrome and its direct and indirect economic and social effects. All compounds used in the current study had no side effects, were effective, non-chemical, and acceptable by most groups of women in the society.

Hence, health groups, especially midwives, can compare the effectiveness the compound on their specific patients and select the most appropriate treatment for each individual. Moreover, in cases where the patient is prohibited from using chemical drugs to treat premenstrual syndrome, such as oral contraceptive pills and gonadotropin releasing hormone (GnRH) agonists, the use of these compounds seems effective …”

Unfortunately, a combination of magnesium and B6 was not evaluated in this study. It would have been interesting to see what their combined effect would have been. Considering the importance of both of these nutrients for health, I see no risk in combining them, though, should you struggle with premenstrual syndrome.

The Importance of Magnesium for Optimal Health

Magnesium8 is the fourth most abundant mineral in your body and the second most common intracellular cation9 (positively charged ion) after potassium. It’s required for the healthy function of most cells in your body, but is especially important for your heart, kidneys and muscles.

Low magnesium will impede your cellular metabolic function and deteriorate mitochondrial function, which can have far-reaching health consequences, seeing how loss of mitochondrial function is a foundational factor in most chronic diseases, including heart disease and cancer.

According to one scientific review,10 which included studies dating as far back as 1937, low magnesium actually appears to be the greatest predictor of heart disease, and other recent research shows even subclinical magnesium deficiency can compromise your cardiovascular health.11

Being one of the most abundant minerals in the human body, it’s not surprising that it has several hundred biological functions. To list just a few, magnesium helps:

  • Relax your muscles as well as your blood vessels — Being deficient in it can cause muscle cramps and weakness
  • Promote mental and physical relaxation — It’s a stress antidote that works by boosting GABA, an inhibitory neurotransmitter that relaxes your nervous system. Magnesium also helps boost your melatonin production
  • Detoxification and reduces damage from electromagnetic fields
  • Regulate blood sugar and improve insulin sensitivity, potentially protecting against Type 2 diabetes

Magnesium Is Required for Activation of Vitamin D

Magnesium is also a component necessary for the activation of vitamin D,12,13,14 and deficiency may hamper your ability to convert vitamin D from sun exposure and/or oral supplementation.

According to Mohammed Razzaque, professor of pathology at Lake Erie College of Osteopathic Medicine in Pennsylvania, coauthor of a study published in The Journal of the American Osteopathic Association (JAOA) in March 2018,15 “By consuming an optimal amount of magnesium, one may be able to lower the risks of vitamin D deficiency, and reduce the dependency on vitamin D supplements.”

Interestingly, the first paper I ever had published, back in 1985, was also in the JAOA. My paper was about the use of calcium to control hypertension, but if I had written the paper this century, it most certainly would have been about the use of magnesium for that purpose.16

A second study,17 published in The American Journal of Clinical Nutrition in December 2018 also concluded that your magnesium status plays an important role in your vitamin D status. Overall, people with high magnesium intake were less likely to have low vitamin D. They also had a lower mortality risk from cardiovascular disease and bowel cancer.

As explained by Dr. Qi Dai, professor of medicine at Vanderbilt University Medical Center and the lead author of this study, “Magnesium deficiency shuts down the vitamin D synthesis and metabolism pathway.” What’s more, magnesium was found to have a regulating effect, raising and lowering vitamin D based on baseline levels.

In people who had a baseline vitamin D level of 30 ng/mL (75 nmol/L) or below, magnesium supplementation raised their vitamin D level. However, in those who started out with higher vitamin D levels (50 ng/mL or 125 nmol/L), magnesium supplementation lowered their vitamin D.

Magnesium for Brain Health and Neurological Functioning

Magnesium is also crucial for optimal brain function, and is a common culprit in neurological ailments, including:

Migraines18,19,20 Researchers have noted that empiric treatment with a magnesium supplement is justified for all migraine sufferers.21

Depression — Magnesium plays an important role in depression as it acts as a catalyst for mood-regulating neurotransmitters like serotonin. Research22 published in 2015 found a significant association between very low magnesium intake and depression, especially in younger adults.

Research23 published in PLOS ONE demonstrated magnesium supplementation improved mild-to-moderate depression in adults, with beneficial effects occurring within two weeks of treatment. In fact, the effects of magnesium were comparable to prescription SSRIs in terms of effectiveness, but without any of the side effects associated with these drugs.

Participants in the treatment group received a daily dose of 248 milligrams (mg) of elemental magnesium for six weeks, while controls received no treatment. According to the authors, “It works quickly and is well tolerated without the need for close monitoring for toxicity.”

Memory problems and loss of brain plasticity — Memory impairment occurs when the connections (synapses) between brain cells diminish. While many factors can come into play, magnesium is an important one.

According to Dr. David Perlmutter, a neurologist and fellow of the American College of Nutrition, “magnesium is a critical player in the activation of nerve channels that are involved in synaptic plasticity.”24 Magnesium threonate, which most effectively permeates the blood-brain-barrier, is likely your best choice here.

The specific brain benefits of magnesium threonate were demonstrated in a 2010 study25 published in the journal Neuron, which found this form of magnesium enhanced “learning abilities, working memory, and short- and long-term memory in rats.”

Health Benefits of Vitamin B6

Like magnesium, vitamin B6 (as well as several other B vitamins) also plays an important role in heart and brain health. It is used in the creation of neurotransmitters, and is required for proper brain development during pregnancy and infancy.26

Vitamins B6, B9 (folate, or folic acid in its synthetic form) and B12 may be particularly important for supporting cognitive function as you age, and have been shown to play a major role in the development of dementia, including Alzheimer’s disease, which is the most serious and lethal form.

A primary mechanism of action here is the suppression of homocysteine,27 which tends to be elevated when you have brain degeneration. High homocysteine has also been implicated in the development of atherosclerosis.28,29

The good news is your body can eliminate homocysteine naturally, provided you’re getting enough B9 (folate), B6 and B12. One study confirming this was published in 2010.30 Participants received either a placebo or 800 micrograms (mcg) of folic acid (the synthetic form of B9), 500 mcg of B12 and 20 mg of B6.

The study was based on the presumption that by controlling homocysteine levels you might be able to reduce brain atrophy, thereby slowing the onset of Alzheimer’s. Indeed, after two years those who received the vitamin-B regimen had significantly less brain shrinkage compared to the placebo group.

A 2013 study31 took this research a step further, showing that not only do B vitamins slow brain shrinkage, but they specifically slow shrinkage in brain regions known to be most severely impacted by Alzheimer’s disease.

As in the previous study, participants taking high doses of folic acid and vitamins B6 and B12 lowered their blood levels of homocysteine, decreasing brain shrinkage by as much as 90%. High doses of vitamins B6, B8 (inositol) and B12 have also been shown to significantly reduce symptoms of schizophrenia, more so than standard drug treatments alone.32 Vitamin B6 is also important for healthy:

  • Metabolism, by helping break down amino acids in the muscles to be used as energy and by converting lactic acid to glucose in your liver
  • Immune system, as it helps create white blood cells that fight infections
  • Hair and skin health, by reducing hair loss and alleviating dermatitis

How to Improve Your Magnesium and Vitamin B6 Status

The recommended dietary allowance (RDA) for magnesium ranges from 310 mg to 420 mg for adults over the age of 19, depending on age, gender and pregnancy status,33 and the adult RDA for vitamin B6 is between 1.2 mg and 2 mg per day, depending on age and gender.34

Both magnesium and vitamin B6 are abundant in whole foods. Good sources of magnesium include leafy greens, berries, avocado, seeds, nuts and raw cacao nibs. Eating a primarily processed food diet is the primary culprit in magnesium deficiency, and if you fall into this group, you’d be wise to take a magnesium supplement.

Vitamin B6 is abundant in animal foods such as beef and wild-caught salmon, as well as dark leafy greens, papaya, oranges, cantaloupe, sweet potatoes, avocados, bananas, spinach, pistachios and sunflower seeds.35 Nutritional yeast is another excellent source.

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